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J Zhejiang Univ (Med Sci)  2018, Vol. 47 Issue (1): 71-74    DOI: 10.3785/j.issn.1008-9292.2018.02.10
A case of neuromyelitis optica spectrum disorders complicated with systemic lupus erythematosus and thymoma
ZHOU Haijin1(),XIA Ping2,*(),HU Xingyue2
1. Department of Neurology, the First People's Hospital of Wengling, Taizhou 317500, Zhejiang Province, China
2. Department of Neurology, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou 310016, China
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A 53-year-old male patient presented with hypopsia of his right eye for 2 months and lower extremities weakness for 8 days. Thoracic MRI demonstrated a lesion at T3 level appearing as hyperintense on T2-weighted images with non-enhancement by contrast medium and demyelinating lesion was considered. Aquaporin-4-Ab was positive and the antibody titer was 1:320 in serum. The diagnosis of neuromyelitis optica spectrum disorders was made. In addition, systemic lupus erythematosus and thymoma coexisted in this patient. After methylprednisolone impact treatment, plasma exchange and immunosuppressive therapy, the right vision and lower extremities weakness of the patient were improved.

Key wordsAutoimmune diseases of the nervous system/therapy      Neuromyelitis optica/diagnosis      Aquaporin 4      Lupus erythematosus, systemic/diagnosis      Lupus erythematosus, systemic/therapy      Thymoma/therapy      Case reports     
Received: 10 September 2017      Published: 12 June 2018
CLC:  R593.2  
Corresponding Authors: XIA Ping     E-mail:;
Cite this article:

ZHOU Haijin,XIA Ping,HU Xingyue. A case of neuromyelitis optica spectrum disorders complicated with systemic lupus erythematosus and thymoma. J Zhejiang Univ (Med Sci), 2018, 47(1): 71-74.

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一例53岁男性患者,因“右眼视力下降2个月,伴双下肢无力8 d”入院。胸椎增强MRI提示胸髓T3水平偏右侧信号异常,考虑脱髓鞘病变,血清水通道蛋白质4抗体阳性,效价为1:320,诊断为视神经脊髓炎谱系疾病。该患者同时合并系统性红斑狼疮和胸腺瘤。经甲泼尼龙冲击、血浆置换、免疫抑制剂等治疗后,患者右眼视力及双下肢无力逐渐好转。

关键词: 神经系统自身免疫疾病/治疗,  视神经脊髓炎/诊断,  水通道蛋白质4,  红斑狼疮, 系统性/诊断,  红斑狼疮, 系统性/治疗,  胸腺瘤/治疗,  病例报告 
Fig 1 MRI scanning and enhancement of thoracic spine
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