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| Quantitative analysis of enhanced MRI features for predicting epidermal growth factor receptor gene amplification in glioblastoma multiforme with radiomic method |
| DONG Fei1, LI Qian1, JIANG Biao1, ZENG Qiang2, HUA Jianming1, ZHANG Minming1 |
1. Department of Radiology, the Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310009, China;
2. Department of Neurosurgery, the Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310009, China |
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Abstract Objective: To assess the value of contrast enhanced MRI features for predicting epidermal growth factor receptor (EGFR) gene amplification in glioblastoma multiforme (GBM) with radiomic method.Methods: Eighty patients with EGFR status examined GBM were retrospectively reviewed. The data were randomly divided into a training dataset (60%) and test dataset (40%). Texture features of each case were extracted from the enhanced region and the edema region in contrast enhanced MR images. Principal component analysis was used for dimension reduction. Random forest model, support vector machine model and neural network model were built. Area under the curve (AUC) of the receiver operating characteristics curve was used to assess the performance of models with test dataset.Results: A total of 542 features were extracted from the enhanced region and the edema region. Forty-eight principal components were obtained, which accounted for 100% accumulation contribution rate, and the first 31 principal components were selected for models building, which accounted for 98.5% accumulation contribution rate. The values of AUCs were 0.74, 0.69 and 0.63 for random forest model, support vector machine model and neural network model in the test dataset, respectively.Conclusion: Radiomic method with proper model may have a potential role in predicting the EGFR gene status with enhanced MRI features derived from the enhanced region and the edema region in patients with glioblastoma multiforme.
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Received: 08 May 2017
Published: 25 October 2017
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磁共振成像强化信号特征预测胶质母细胞瘤EGFR基因扩增状态的影像组学研究
目的：探讨采用影像组学研究方法分析胶质母细胞瘤磁共振强化信号特征预测表皮生长因子受体（EGFR）基因扩增状态的可行性。方法：收集术前行颅脑平扫及增强磁共振检查的80例经常规病理学检查确诊为胶质母细胞瘤并行分子病理学EGFR基因扩增状态检测的患者，按3：2比例随机分组至训练数据集和测试数据集。利用半自动软件高通量提取患者增强磁共振图像中强化区及周围水肿区的定量信号特征，经主成分分析等数据处理后利用随机森林模型、支持向量机模型和神经网络模型进一步分析数据，以测试数据集模型的受试者工作特征曲线下面积（AUC）作为模型的评价指标。结果：共提取强化区及水肿区特征542个，经主成分分析得到48个主成分（累积贡献率为100%），选择其中31个主成分（累积贡献率为98.5%）建模。随机森林模型、支持向量机模型和神经网络模型在测试数据集的AUC值分别为0.74、0.69和0.63。结论：采用影像组学研究方法分析胶质母细胞瘤强化信号特征并选择合适的模型进行分析对胶质母细胞瘤EGFR基因扩增状态有一定的预测价值。
关键词：
胶质母细胞瘤/病理学,
受体,
基因扩增,
图像处理,
计算机辅助,
人工智能,
磁共振成像,
表皮生长因子
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| [[1]] |
WIRSCHING H G, GALANIS E, WELLER M. Glioblastoma[J]. Handb Clin Neurol,2016,134:381-397.
|
|
|
| [[2]] |
ALDAPE K, ZADEH G, MANSOURI S, et al. Glioblastoma:pathology, molecular mechanisms and markers[J]. Acta Neuropathol,2015,129(6):829-848.
|
|
|
| [[3]] |
HALATSCH M E, SCHMIDT U, BEHNKE-MURSCH J, et al. Epidermal growth factor receptor inhibition for the treatment of glioblastoma multiforme and other malignant brain tumours[J]. Cancer Treat Rev,2006,32(2):74-89.
|
|
|
| [[4]] |
RAMIS G, THOMÀS-MOYÀ E, DE MATTOS S F, et al. EGFR inhibition in glioma cells modulates Rho signaling to inhibit cell motility and invasion and cooperates with temozolomide to reduce cell growth[J/OL]. PLoS One,2012,7(6):e38770.
|
|
|
| [[5]] |
BRENNAN C W, VERHAAK R G, MCKENNA A, et al. The somatic genomic landscape of glioblastoma[J]. Cell,2013,155(2):462-477.
|
|
|
| [[6]] |
LIU F, HON G C, VILLA G R, et al. EGFR mutation promotes glioblastoma through epigenome and transcription factor network remodeling[J]. Mol Cell,2015,60(2):307-318.
|
|
|
| [[7]] |
VERHAAK R G, HOADLEY K A, PURDOM E, et al. Integrated genomic analysis identifies clinically relevant subtypes of glioblastoma characterized by abnormalities in PDGFRA, IDH1, EGFR, and NF1[J]. Cancer Cell,2010,17(1):98-110.
|
|
|
| [[8]] |
YOUNG R J, GUPTA A, SHAH A D, et al. Potential role of preoperative conventional MRI including diffusion measurements in assessing epidermal growth factor receptor gene amplification status in patients with glioblastoma[J]. AJNR Am J Neuroradiol,2013,34(12):2271-2277.
|
|
|
| [[9]] |
GUTMAN D A, DUNN W D, GROSSMANN P, et al. Somatic mutations associated with MRI-derived volumetric features in glioblastoma[J]. Neuroradiology,2015,57(12):1227-1237.
|
|
|
| [[10]] |
LAL A, GLAZER C A, MARTINSON H M, et al. Mutant epidermal growth factor receptor up-regulates molecular effectors of tumor invasion[J]. Cancer Res,2002,62(12):3335-3339.
|
|
|
| [[11]] |
GOLDMAN C K, KIM J, WONG W L, et al. Epidermal growth factor stimulates vascular endothelial growth factor production by human malignant glioma cells:a model of glioblastoma multiforme pathophysiology[J]. Mol Biol Cell,1993,4(1):121-133.
|
|
|
| [[12]] |
MABRAY M C, BARAJAS R F, CHA S. Modern brain tumor imaging[J]. Brain Tumor Res Treat,2015,3(1):8-23.
|
|
|
| [[13]] |
HUANG Y Q, LIANG C H, HE L, et al. Development and validation of a radiomics nomogram for preoperative prediction of lymph node metastasis in colorectal cancer[J]. J Clin Oncol,2016,34(18):2157-2164.
|
|
|
| [[14]] |
LARUE R T, DEFRAENE G, DE RUYSSCHER D, et al. Quantitative radiomics studies for tissue characterization:a review of technology and methodological procedures[J]. Br J Radiol,2017,90(1070):20160665.
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