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Journal of ZheJiang University(Medical Science)  2016, Vol. 45 Issue (5): 501-507    DOI: 10.3785/j.issn.1008-9292.2016.09.08
Progress on anti-tumor molecular mechanisms of dihydroartemisinin
CAO Peng, LENG Dongjin, LI Ying, ZHANG Ziwei, LIU Lei, LI Xiaoyan
College of Life Science, Northeast Forest University, Harbin 150040, China
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Artemisinin is an anti-malarial drug with poor water solubility and oral absorption; so a variety of derivatives based on the parent nucleus have been developed. Compared with artemisinin, dihydroartemisinin (DHA) has a stronger anti-malaria activity, and has the advantages of high metabolic rate and better water solubility. Recent studies have discovered that DHA has a good inhibitory effect on tumor cells, which is closely related to the peroxide bridge in its molecular structure. Since tumor cells need more Fe3+ than normal cells, there are a large number of transferrin receptors on the tumor cell membrane. DHA can break the peroxide bridge in the presence of Fe2+, and the free radicals generated can play its lethal effect on tumor cells. In addition, DHA can promote endocytosis of transferrin receptor, and thus prevent cancer cells from taking Fe3+ from microenvironment. This article reviews the anti-tumor molecular mechanism of DHA, including accelerating oxidative damage, inducing apoptosis, inhibiting the growth, proliferation and invasion of tumor cells, reversing tumor multidrug resistance.

Key wordsArtemisinin/analogs &      derivatives      Artemisinin/pharmacology      Antineoplastic drugs (TCD)/therapeutic use      Apoptosis/drug effects      Cell proliferation/drug effects      Neoplasm invasiveness      Neoplasm metastasis      Review     
Received: 23 October 2015      Published: 25 September 2016
CLC:  R966  
Cite this article:

CAO Peng, LENG Dongjin, LI Ying, ZHANG Ziwei, LIU Lei, LI Xiaoyan. Progress on anti-tumor molecular mechanisms of dihydroartemisinin. Journal of ZheJiang University(Medical Science), 2016, 45(5): 501-507.

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关键词: 青蒿素/类似物和衍生物,  青蒿素/药理学,  抗肿瘤药(中药)/治疗应用,  细胞凋亡/药物作用,  细胞增殖/药物作用,  肿瘤侵润,  肿瘤转移,  综述 
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