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Journal of ZheJiang University(Medical Science)  2011, Vol. 40 Issue (4): 391-394    DOI: 10.3785/j.issn.1008-9292.2011.04.008
    
Protective effect of Jiangbaiweiyan tablet on ethanol-induced gastric mucosa injury in rats
FU Xu-chun1,SHAN Hai-li2,BAI Hai-bo3,HU Rong3
1.School of Medicine and Life Science,Zhejiang University City College,Hangzhou 310015,China; 2.The Second Affiliated Hospital,College of Medicine,Zhejiang University,Hangzhou 31009,China; 3.Hangzhou East China Pharmaceutical Bioengineer Institute Co Ltd,Hangzhou 310012,China
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Abstract  Objective: To investigate the effect of Jiangbaiweiyan tablet,a Chinese medicine compound composed of Alpinta Officinarum,Cyperus Rotundus,Bulbus Lilii and Rlindera Strychnifolia,on ethanol-induced gastric mucosa injury in rats.
Methods: Acute gastric ulcer was induced in rats with absolute ethyl alcohol. The ulcer index was used to evaluate the extent of the gastric mucosa injury.
Results: The ulcer indexes of the model group,the mid-dose(1.08 g·kg-1·d-1)and high-dose(2.16 g·kg-1·d-1)of Jiangbaiweiyan tablet groups were 141.58±47.43,24.83±23.04 and 2.12±2.58,respectively (P﹤0.01).
Conclusions: Jiangbaiweiyan tablet has protective effects on ethanol-induced gastric mucosa injury in rats,which may be related to anti-oxidation and enhancing tissue regeneration capacity.


Key wordsJiangbaiweiyan tablet      Gastric mucosa/drug eff      Gastric mucosa/pathol      Tablets      Disease models,animal      Absolute ethyl alcohol      Gastric mucosa injury      Ulcer index     
Published: 25 July 2010
Cite this article:

. Protective effect of Jiangbaiweiyan tablet on ethanol-induced gastric mucosa injury in rats. Journal of ZheJiang University(Medical Science), 2011, 40(4): 391-394.

URL:

https://www.zjujournals.com/med/10.3785/j.issn.1008-9292.2011.04.008     OR     https://www.zjujournals.com/med/Y2011/V40/I4/391


姜百胃炎片对大鼠乙醇胃黏膜损伤模型的影响

目的:研究由高良姜、香附、百合和乌药提取物制成的复方中药姜百胃炎片,对大鼠乙醇胃黏膜损伤模型的胃黏膜保护作用。
方法:采用无水乙醇灌胃法建立大鼠乙醇胃粘膜损伤模型,以溃疡指数表示大鼠胃黏膜损伤程度,比较姜百胃炎片给药组和模型组的差别。
结果:模型组、姜百胃炎片中剂量组(1.08 g·kg-1·d-1)和姜百胃炎片高剂量组(2.16 g·kg-1·d-1)的溃疡指数分别为141.58±47.43、24.83±23.04 和2.12±2.58 ,姜百胃炎片可以显著降低大鼠乙醇胃黏膜损伤模型的溃疡指数(P<0.01)。
结论:姜百胃炎片对大鼠乙醇胃黏膜损伤模型的胃黏膜具有保护作用,该作用可能与其具有抗氧化能力,以及增强组织自身生长和修复能力等有关。

关键词: 姜百胃炎片,  胃黏膜/药物作用,  胃黏膜/病理学,  片剂,  疾病模型,  动物,  无水乙醇,  胃黏膜损伤,  溃疡指数 
[1] Hu Shaoyu, Chen Zhiqun, Yuan Hong, et al. Relative Dissolution of Tinidazole Buccal Tablets and its Concentration in Saliva[J]. Journal of ZheJiang University(Medical Science), 1998, 27(3): 112-113.