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Journal of ZheJiang University(Medical Science)  2011, Vol. 40 Issue (5): 495-500    DOI: 10.3785/j.issn.1008-9292.2011.05.006
TLR4 and organ transplant rejection
Department of Bone Marrow Transplantation Center,The First Affiliated Hospital,Zhejiang University School of Medicine,Hangzhou 310003,China
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Abstract  Organ transplant has become one of the strategies for treatment of malignant disease.The transplant-related complications restricted the further development of organ transplantation; graft rejection is most prominent among these complications,which remains a major cause of morbidity and mortality after organ transplant.Toll like receptors 4 (TLR-4) has been shown as a key molecule in innate immunity and immune tolerance.The role of TLR4 in graft rejection after organ transplant is still unknown.This article will review the role and the mechanism of TLR4 to control APC mature,activate T cells,trigger immune attack to organ graft; therefore bring new insights into the pathophysiology of graft rejection and foster the development of new therapies to control graft rejection after organ transplant.

Key wordsToll-like receptor 4      Organ transplantation      Graft rejection     
Published: 25 September 2011
Cite this article:

. TLR4 and organ transplant rejection. Journal of ZheJiang University(Medical Science), 2011, 40(5): 495-500.

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关键词: Toll样受体4,  器官移植,  移植物排斥 
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