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J Zhejiang Univ (Med Sci)  2017, Vol. 46 Issue (1): 80-88    DOI: 10.3785/j.issn.1008-9292.2017.02.12
    
Application progress on near infrared spectroscopy in quality control and process monitoring of traditional Chinese medicine
LI Wenlong(),QU Haibin()
Pharmaceutical Informatics Institute, Zhejiang University, Hangzhou 310058, China
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Abstract  

The industry of traditional Chinese medicine (TCM) encounters problems like quality fluctuation of raw materials and unstandardized production process. Near infrared (NIR) spectroscopy technology is widely used in quality control of TCM because of its abundant information, fast and nondestructive characters. The main applications include quantitative analysis of Chinese medicinal materials, intermediates and Chinese patent medicines; the authenticity of TCM, species, origins and manufacturers; monitoring and control of the extraction, alcohol precipitation, column chromatography and blending process. This article reviews the progress on the application of NIR spectroscopy technology in TCM field. In view of the problems existing in the application, the article proposes that the standardization of NIR analysis method should be developed according to specific characteristics of TCM, which will promote the application of NIR technology in the TCM industry.



Key wordsSpectroscopy, near-infrared      TCD IDENTIFICATION/methods      Quality control      Drugs, Chinese herbal/analysis      Drug monitoring      Review     
Received: 20 December 2016      Published: 06 July 2017
CLC:  R917  
Corresponding Authors: QU Haibin     E-mail: wshlwl@zju.edu.cn;quhb@zju.edu.cn
About author: QU Haibin, E-mail: quhb@zju.edu.cn
Cite this article:

LI Wenlong,QU Haibin. Application progress on near infrared spectroscopy in quality control and process monitoring of traditional Chinese medicine. J Zhejiang Univ (Med Sci), 2017, 46(1): 80-88.

URL:

http://www.zjujournals.com/med/10.3785/j.issn.1008-9292.2017.02.12     OR     http://www.zjujournals.com/med/Y2017/V46/I1/80


近红外光谱应用于中药质量控制及生产过程监控的研究进展

目前中药生产过程存在原料质量波动较大、制药过程模糊等问题。近红外光谱分析技术具有信息丰富、分析快速、样品无损等特点,近年来已成功运用于中药材、中间体、中成药等定量分析,中药的真α 、基源、产地、生产厂家等鉴别,以及中药提取、醇沉、柱层析、混料等生产过程的监控。本文对近红外光谱分析技术在中药领域的应用进行综述,并针对其应用中缺乏必要的标准等问题,提出结合中药具体特点来开展近红外光谱分析技术的规范化研究,以期推动该技术在中药行业更为广泛的应用。


关键词: 谱学, 近红外线,  中药鉴定/方法,  质量控制,  中草药/分析,  药物监测,  综述 
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