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J Zhejiang Univ (Med Sci)  2020, Vol. 49 Issue (1): 113-117    DOI: 10.3785/j.issn.1008-9292.2020.02.12
Research advance of ANRIL on atherosclerosis by regulating cell proliferation and apoptosis
FANG Juan(),PAN Zhicheng,GUO Xiaogang*()
Department of Cardiology, the First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310003, China
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Atherosclerosis is an important pathological basis for coronary artery disease. ANRIL is an antisense non-coding RNA located in Chr9p21 locus, which was identified as the most significant risk locus associated with atherosclerosis. ANRIL can produce multiple transcripts including linear and circular transcripts after various transcript splicing. It has been illustrated that ANRIL plays important roles in the pathology of atherosclerosis by regulating the proliferation and apoptosis of vascular cells. Linear ANRIL can regulate the proliferation of vascular smooth muscle cells (VSMCs) in plaques by chromatin modification, as well as influence the proliferation and the apoptosis of macrophages in post transcription; circular ANRIL can affect the proliferation and apoptosis of VSMCs by chromatin modification as well as interfering with rRNA maturation. In this review, we describe the ANRIL evolution, different transcripts characteristics, and their roles in the proliferation and apoptosis of vascular cells to participate in the process of atherosclerosis, for further understanding the pathogenesis of atherosclerosis and finding potential targets for diagnosis and treatment of atherosclerosis.

Key wordsAtherosclerosis      Antisense non-coding RNA in the INK4 locus      Cell proliferation      Apoptosis      Review     
Received: 02 December 2019      Published: 08 June 2020
CLC:  R543.5  
Corresponding Authors: GUO Xiaogang     E-mail:;
Cite this article:

FANG Juan,PAN Zhicheng,GUO Xiaogang. Research advance of ANRIL on atherosclerosis by regulating cell proliferation and apoptosis. J Zhejiang Univ (Med Sci), 2020, 49(1): 113-117.

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关键词: 动脉粥样硬化,  INK4基因座中反义非编码RNA,  细胞增殖,  细胞凋亡,  综述 
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