Research progress on early identification of severe adenovirus pneumonia in children

doi:10.3785/j.issn.1008-9292.2019.10.16

J Zhejiang Univ (Med Sci)

2019, Vol. 48

Issue (5): 567-572 DOI: 10.3785/j.issn.1008-9292.2019.10.16

Research progress on early identification of severe adenovirus pneumonia in children

LIN Jing(

),CHEN Zhimin*(

)

The Children's Hospital, Zhejiang University School of Medicine, National Clinical Research Center for Child Health, Hangzhou 310052, China

Download:

HTML( 15 )

PDF(748KB)
Export: BibTeX | EndNote (RIS)

Abstract

Severe adenovirus pneumonia has a high mortality and incidence of sequelae. Fever and cough are the main symptoms of children's severe adenovirus pneumonia, but such clinical manifestations are lack of specificity. For children with persistent high fever who are in the epidemic age and season, the adenovirus etiology detection, blood routine, cytokines, T cell subsets and imaging examinations are suggested. Children with early manifestations of infiltration of lung segment and lobar parenchyma, obvious emphysema, interstitial pneumonia or a large amount of pleural effusion should be alerted to have severe adenovirus pneumonia. This article reviews the epidemiological characteristics and risk factors of adenovirus pneumonia in different seasons, regions and serology, and the laboratory findings and imaging features of severe adenovirus pneumonia, which would be helpful for the early identification of the disease.

Key words： Adenovirus infections, human/epidemiology Child Pneumonia, viral/diagnosis Risk factors Review

Received: 08 July 2019 Published: 04 January 2020

CLC:

R725.6

Corresponding Authors: CHEN Zhimin E-mail: 21718455@zju.edu.cn;zmchen@zju.edu.cn

	Service
	E-mail this article
	Add to my bookshelf
	Add to citation manager
	E-mail Alert
	RSS
	Articles by authors
	LIN Jing
	CHEN Zhimin

Cite this article:

LIN Jing,CHEN Zhimin. Research progress on early identification of severe adenovirus pneumonia in children. J Zhejiang Univ (Med Sci), 2019, 48(5): 567-572.

URL:

http://www.zjujournals.com/med/10.3785/j.issn.1008-9292.2019.10.16 OR http://www.zjujournals.com/med/Y2019/V48/I5/567

儿童重症腺病毒肺炎早期识别的研究进展

重症腺病毒肺炎患儿具有较高的病死率及后遗症发生率。儿童重症腺病毒肺炎以发热、咳嗽为主要症状，无明显特异性。一般来说，对于处于好发年龄及流行季节内的儿童，出现持续高热不退，应早期完善腺病毒病原学检测、血常规、细胞因子、T细胞亚群等检测及影像学检查。其中，影像学检查发现早期表现为肺段及大叶实质浸润、明显肺气肿、间质性肺炎改变或合并大量胸腔积液的患儿，应警惕为重症腺病毒肺炎。本文综述了腺病毒肺炎不同季节、地区、血清学的流行病学特点，重症腺病毒肺炎的高危因素、实验室检测及影像学早期表现，以期为重症腺病毒肺炎的早期识别提供参考。

关键词： 腺病毒感染, 人/流行病学, 儿童, 肺炎, 病毒性/诊断, 危险因素, 综述


[1]	张其威.人呼吸道腺病毒感染的流行、预防和治疗[C].广州: 2018新发传染病研究热点研讨会, 2018: 1. ZHANG Qiwei. Prevalence, prevention and treatment of human respiratory adenovirus infection[C]. Guangzhou: 2018 symposium on emerging infectious diseases, 2018: 1. (in Chinese)

[2]	潘丽峰, 傅慧琴, 崔琪奇 et al. 上海市浦东新区引起腹泻的腺病毒分子流行病学特征[J]. 职业与健康, 2019, 35 (2): 176- 179 PAN Lifeng , FU Huiqin , CUI Qiqi et al. Molecular epidemiology characterization analysis of diarrhea caused by adenovirus in Pudong new district of Shanghai[J]. Occupation and Health, 2019, 35 (2): 176- 179

[3]	FADEN H , WILBY M , HAINER Z D et al. Pediatric adenovirus infection: relationship of clinical spectrum, seasonal distribution, and serotype[J]. Clin Pediatr (Phila), 2011, 50 (6): 483- 487 doi: 10.1177/0009922810392775

[4]	BRANDT C D , KIM H W , VARGOSKO A J et al. Infections in 18000 infants and children in a controlled study of respiratory tract disease: Ⅰ. Adenovirus pathogenicity in relation to serologic type and illness syndrome[J]. Am J Epidemiol, 1969, 90 (6): 484- 500 doi: 10.1093/oxfordjournals.aje.a121094

[5]	崔小文 . 小儿重症腺病毒肺炎混合感染特征及高危因素分析[J]. 当代医学, 2017, 23 (24): 16- 18 CUI Xiaowen . Analysis of mixed infection characteristics and risk factors of severe adenovirus pneumonia in children[J]. Contemporary Medicine, 2017, 23 (24): 16- 18 doi: 10.3969/j.issn.1009-4393.2017.24.007

[6]	胡亚美, 江载芳 . 诸福棠实用儿科学[M]. 8版北京: 人民卫生出版社, 2015. HU Yamei , JIANG Zaifang . Practical pediatrics[M]. 8th ed Beijing: people's medical publishing house, 2015.

[7]	王和平, 郑跃杰, 赵海霞 et al. 25602例住院儿童呼吸道腺病毒感染检出分析[J]. 重庆医学, 2018, 47 (12): 1661- 1663 WANG Heping , ZHENG Yuejie , ZHAO Haixia et al. Analysis of respiratory adenovirus infection in 25, 602 hospitalized children[J]. Chongqing Medicine, 2018, 47 (12): 1661- 1663 doi: 10.3969/j.issn.1671-8348.2018.12.023

[8]	冯晓妍, 吴敏 . 人腺病毒感染流行病学研究进展[J]. 医学动物防制, 2016, 32 (5): 518- 520 FENG Xiaoyan , WU Min . Progress in the epidemiology of human adenovirus infection[J]. Journal of Medical Animal Control, 2016, 32 (5): 518- 520

[9]	陈伟, 秦珑, 王盛书 et al. 某学校一起呼吸道腺病毒7型暴发疫情调查与处置[J]. 军事医学, 2017, 12 (41): 994- 997 CHEN Wei , QIN Long , WANG Shengshu et al. Investigation and management of an outbreak of respiratory adenovirus type 7 in a school[J]. Military Medicine, 2017, 12 (41): 994- 997

[10]	焦素黎, 倪红霞, 陈冰冰 et al. 一起腺病毒引起的小学呼吸道感染聚集性疫情调查和实验室检测[J]. 中国卫生检验杂志, 2018, 21 (28): 2646- 2648 JIAO Suli , NI Hongxia , CHEN Bingbing et al. Investigation and laboratory test of a case of respiratory tract infection caused by adenovirus in primary school[J]. Chinese Journal of Health Laboratory, 2008, 21 (28): 2646- 2648

[11]	MEI Y F , SKOG J , LINDMAN K et al. Comparative analysis of the genome organization of human adenovirus 11, a member of the human adenovirus species B, and the commonly used human adenovirus 5 vector, a member of species C[J]. J Gen Virol, 2003, 84 (Pt 8): 2061- 2071

[12]	CHEHADEH W , AL-ADWANI A , JOHN S E et al. Adenovirus types associated with severe respiratory diseases: A retrospective 4-year study in Kuwait[J]. J Med Virol, 2018, 90 (6): 1033- 1039 doi: 10.1002/jmv.25059

[13]	XU L , LIU J , LIU C et al. Case-control study of the epidemiological and clinical features of human adenovirus 55 and human adenovirus 7 infection in children with acute lower respiratory tract infections in Beijing, China, 2008-2013[J]. BMC Infect Dis, 2018, 18 (1): 634 doi: 10.1186/s12879-018-3520-z

[14]	杜芳, 黄英, 舒畅 et al. 小儿重症腺病毒肺炎混合感染及高危因素分析[J]. 中国当代儿科杂志, 2013, 15 (5): 375- 378 DU Fang , HUANG Ying , SHU Chang et al. Mixed infection and risk factors analysis of severe adenovirus pneumonia in children[J]. Chinese Journal of Contemporary Pediatrics, 2013, 15 (5): 375- 378

[15]	阮继锋, 温敏宜 . 小儿重症腺病毒肺炎混合感染特征及高危因素分析[J]. 深圳中西医结合杂志, 2016, 26 (10): 15- 16 RUAN Jifeng , WEN Minyi . Analysis of mixed infection characteristics and risk factors of severe adenovirus pneumonia in children[J]. Shenzhen Journal of Integrated Traditional Chinese and Western Medicine, 2016, 26 (10): 15- 16

[16]	罗力妍, 饶花平, 徐畅 et al. 儿童重症腺病毒肺炎危险因素分析[J]. 中国中西医结合儿科学, 2014, 6 (6): 549- 550 LUO Liyan , RAO Huaping , XU Chang et al. Risk factors analysis of severe adenovirus pneumonia in children[J]. Pediatrics of Integrated Traditional Chinese and Western Medicine in China, 2014, 6 (6): 549- 550 doi: 10.3969/j.issn.1674-3865.2014.06.029

[17]	郑申健, 胡俊, 汪珍珍 et al. 重度腺病毒肺炎患儿预后不良相关危险因素[J]. 中国感染控制杂志, 2016, 15 (8): 587- 591 ZHENG Shenjian , HU Jun , WANG Zhenzhen et al. Risk factors associated with poor prognosis in children with severe adenovirus pneumonia[J]. Chinese Journal of Infection Control, 2016, 15 (8): 587- 591 doi: 10.3969/j.issn.1671-9638.2016.08.012

[18]	XIE L , ZHANG B , ZHOU J et al. Human adenovirus load in respiratory tract secretions are predictors for disease severity in children with human adenovirus pneumonia[J]. Virol J, 2018, 15 (1): 123 doi: 10.1186/s12985-018-1037-0

[19]	刘爱良, 黄英, 杨洋 et al. 儿童重症腺病毒肺炎213例临床特征分析[J]. 临床儿科杂志, 2013, 31 (8): 726- 729 LIU Ailiang , HUANG Ying , YANG Yang et al. Analysis of 213 cases of severe adenovirus pneumonia in children[J]. Journal of Clinical Pediatrics, 2013, 31 (8): 726- 729 doi: 10.3969/j.issn.1000-3606.2013.08.007

[20]	王佳伟.重症腺病毒肺炎患儿T细胞亚群及细胞因子水平变化及其临床意义的研究[D].杭州: 浙江大学, 2018. WANG Jiawei. Changes and clinical significance of t-cell subsets and cytokines in children with severe adenovirus pneumonia [D]. Hangzhou: Zhejiang University, 2018. (in Chinese)

[21]	郑丽丽, 许航燕, 应旦红 et al. 重症腺病毒肺炎患儿T细胞亚群变化及其临床意义的研究[J]. 浙江医学, 2018, 40 (15): 1702- 1704 ZHENG Lili , XU Hangyan , YING Danhong et al. Changes and clinical significance of t-cell subsets in children with severe adenovirus pneumonia[J]. Zhejiang Medical Journal, 2008, 40 (15): 1702- 1704

[22]	LAI C Y, LEE C J, LUC Y, et al. Adenovirus serotype 3 and 7 infection with acute respiratory failure in children in Taiwan, 2010-2011[J/OL]. PLoS One, 2013, 8(1): e53614.

[23]	婧奕, 王斐, 徐婷婷 et al. 儿童重症监护病房重症腺病毒肺炎特点和救治方法探讨[J]. 中国小儿急救医学, 2019, 26 (3): 190- 194 JING Yi , WANG Fei , XU Tingting et al. Characteristics and treatment of severe adenovirus pneumonia in pediatric intensive care unit[J]. Chinese Pediatric Emergency Medicine, 2019, 26 (3): 190- 194 doi: 10.3760/cma.j.issn.1673-4912.2019.03.007

[24]	党润, 艾斌, 杨镒宇 et al. 儿童重症腺病毒肺炎不同阶段的临床影像学特征[J]. 分子影像学杂志, 2018, 41 (4): 426- 430 DANG Run , AI Bin , YANG Yiyu et al. Clinical imaging characteristics of severe adenovirus pneumonia in children at different stages[J]. Journal of Molecular Imaging, 2008, 41 (4): 426- 430

[25]	李晶, 岳学静, 郭喜霞 et al. 重症腺病毒肺炎患儿临床特征及CT诊断分析[J]. 中国CT和MRI杂志, 2019, 17 (3): 1- 4 LI Jing , YUE Xuejing , GUO Xixia et al. Clinical characteristics and CT diagnosis analysis of children patients with severe adenovirus pneumonia[J]. Chinese Journal of CT and MRI, 2019, 17 (3): 1- 4 doi: 10.3969/j.issn.1672-5131.2019.03.001

[1]	ZHANG Junhao,JIN Jinghua,YANG Wei. Autophagy regulates the function of vascular smooth muscle cells in the formation and rupture of intracranial aneurysms[J]. J Zhejiang Univ (Med Sci), 2019, 48(5): 552-559.

[2]	CHEN Dianyu,QI Ming. Research progress on uniparental disomy in cancer[J]. J Zhejiang Univ (Med Sci), 2019, 48(5): 560-566.

[3]	Mehmutjan Muzepper,ZHOU Min. Risk factors of pelvic ischemic symptoms after iliac artery occlusion during endovascular aneurysm repair[J]. J Zhejiang Univ (Med Sci), 2019, 48(5): 546-551.

[4]	XU Jiajun,SHU Qiang. Application of 3D printing techniques in treatment of congenital heart disease[J]. J Zhejiang Univ (Med Sci), 2019, 48(5): 573-579.

[5]	HUANG Shumin,ZHAO Zhengyan. Advances in newborn screening and immune system reconstitution of severe combined immunodeficiency[J]. J Zhejiang Univ (Med Sci), 2019, 48(4): 351-357.

[6]	CHEN Guangjie,WANG Xiaohao,TANG Daxing. Progress on evaluation, diagnosis and management of disorders of sex development[J]. J Zhejiang Univ (Med Sci), 2019, 48(4): 358-366.

[7]	ZHANG Jianmin. Advances in surgical treatment of ischemic cerebrovascular disease[J]. J Zhejiang Univ (Med Sci), 2019, 48(3): 233-240.

[8]	WU Yuxing, ZHANG Shihong, CHEN Zhong. The roles of habenula and related neural circuits in neuropsychiatric diseases[J]. J Zhejiang Univ (Med Sci), 2019, 48(3): 310-317.

[9]	ZHANG Yunzhu, ZHU Chunpeng, LU Xinliang. Advances in serum biomarkers for early diagnosis of gastric cancer[J]. J Zhejiang Univ (Med Sci), 2019, 48(3): 326-333.

[10]	TAO Anyang, WANG Zhimin, CHEN Hongfang, XU Dongjuan, HU Haifang, WU Chenglong, ZHANG Xiaoling, MA Xiaodong, WANG Yaxian, HU Haitao, LOU Min, Improving In-hospital Stroke Service Utilisation (MISSION) in Zhejiang Province . Association of atrial fibrillation with hemorrhagic transformation after intravenous thrombolysis in patients with ischemic stroke[J]. J Zhejiang Univ (Med Sci), 2019, 48(3): 254-259.

[11]	ZHU Ziling, TAN Jing, DENG Hong. Nucleus translocation of membrane/cytoplasm proteins in tumor cells[J]. J Zhejiang Univ (Med Sci), 2019, 48(3): 318-325.

[12]	Baboo Kalianee Devi,CHEN Zhengyun,ZHANG Xinmei. Progress on medical treatment in the management of adenomyosis[J]. J Zhejiang Univ (Med Sci), 2019, 48(2): 142-147.

[13]	WU Binbin,YANG Yi. Biomarkers of cardiac surgery-associated acute kidney injury: a narrative review[J]. J Zhejiang Univ (Med Sci), 2019, 48(2): 224-229.

[14]	YANG Kun,HU Xiaosheng. Research progress on miR-21 in heart diseases[J]. J Zhejiang Univ (Med Sci), 2019, 48(2): 214-218.

[15]	XU Li,XU Ming,TONG Xiangmin. Effects of aerobic glycolysis on pathogenesis and drug resistance of non-Hodgkin lymphoma[J]. J Zhejiang Univ (Med Sci), 2019, 48(2): 219-223.

Viewed

Full text

Abstract

Cited

Shared

Discussed