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浙江大学学报（医学版）
J Zhejiang Univ (Med Sci)  2019, Vol. 48 Issue (3): 318-325    DOI: 10.3785/j.issn.1008-9292.2019.06.13
    
Nucleus translocation of membrane/cytoplasm proteins in tumor cells
ZHU Ziling(),TAN Jing,DENG Hong*()
Zhejiang Key Laboratory for Disease Proteomics, Department of Pathology, Zhejiang University School of Medicine, Hangzhou 310058, China
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Abstract  

Proteins are the physical basis of life and perform all kinds of life activities. Proteins have different orientations and function in different tissues. The same protein, located in different subcellular regions, can perform different and even opposite functions. Both functional and structural proteins are capable of undergoing re-localization which can directly or indirectly participate in signal transduction. Due to abnormal transduction of signals during carcinogenesis, the proteins originally expressed in the cytoplasm are translocated into the nucleus and lead to functional changes in the tumor tissue. The changes of protein localization are affected by many factors, including the interaction between proteins, expression level of proteins and the cleaved intracellular domain of transmembrane protein.

Key words： Neoplasms/physiopathology      Proteins/metabolism      Signal transduction      Tumor cells      Review     
Received: 03 December 2018      Published: 04 September 2019
CLC:  R730.2  
Corresponding Authors: DENG Hong     E-mail: ziling_zhu@126.com;hongdeng@zju.edu.cn
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ZHU Ziling
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Cite this article:

ZHU Ziling, TAN Jing, DENG Hong. Nucleus translocation of membrane/cytoplasm proteins in tumor cells. J Zhejiang Univ (Med Sci), 2019, 48(3): 318-325.

URL:

http://www.zjujournals.com/med/10.3785/j.issn.1008-9292.2019.06.13     OR     http://www.zjujournals.com/med/Y2019/V48/I3/318


肿瘤细胞膜/质蛋白转位入核研究进展

蛋白质作为生命物质的基础，在不同组织细胞中呈现不同的定位，执行不同的功能。同种蛋白质在不同的亚细胞区域定位可以发挥不同的功能，甚至表现出截然相反的作用。功能蛋白和结构蛋白都能够发生定位的改变，直接或间接参与信号转导。细胞癌变后，信号异常转导，原本在正常细胞的细胞膜/细胞质中表达的蛋白，却在肿瘤细胞中转位到细胞核而发生功能改变。结构蛋白入核主要通过蛋白断裂、蛋白含量改变以及蛋白相互结合实现。对关键蛋白分子的转位研究，有助于在临床应用中发现新的诊断标志物和治疗靶点。


关键词： 肿瘤/病理生理学,  蛋白质类/代谢,  信号传导,  肿瘤细胞,  综述 
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