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J Zhejiang Univ (Med Sci)  2019, Vol. 48 Issue (1): 34-38    DOI: 10.3785/j.issn.1008-9292.2019.02.06
Application of mechanosensitive channels in sonogenetics
HONG Feifan1(),LI Yuezhou1,2()
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As a non-invasive approach, sonogenetics is applied to control neuronal activity. The mechanosensitive channel(MSC), which has low threshold of responding to ultrasound, may be the alternative solution. Sonogenetics is the technique that activates the MSC expressed in targeted neurons by low intensity ultrasound, thus achieve the neuromodulation. In this review, we introduce the mechanosensitive channel of large conductance, transient receptor potential, channels of the two-pore-domain potassium family, Piezo and the recent progress on their application in sonogenetics.

Key wordsIon channels      Electrophysiology      Ultrasonography      Neurophysiology      Neurons      Review     
Received: 21 August 2018      Published: 10 May 2019
CLC:  Q71  
Corresponding Authors: LI Yuezhou     E-mail:;
Cite this article:

HONG Feifan,LI Yuezhou. Application of mechanosensitive channels in sonogenetics. J Zhejiang Univ (Med Sci), 2019, 48(1): 34-38.

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关键词: 离子通道,  电生理学,  超声检查,  神经生理学,  神经元,  综述 
Figure 1 Mechanism of ultrasonic regulation of neural activity[15]
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