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浙江大学学报（医学版）
J Zhejiang Univ (Med Sci)  2018, Vol. 47 Issue (5): 558-563    DOI: 10.3785/j.issn.1008-9292.2018.10.17
    
Progress on cancer associated fibroblasts in tumor immunoregulation
LI Gaopeng(),HE Jia,WANG Qingqing*()
Institute of Immunology, Zhejiang University School of Medicine, Hangzhou 310058, China
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Abstract  

Cancer associated fibroblasts (CAFs) are important components of the tumor microenvironment. Through secreting of multiple growth factors, cytokines and proteases, CAFs play a significant role in regulating the recruitment and function of various innate immune cells and adaptive immune cells in tumor microenvironment. In addition, extracellular matrix secreted by CAFs can also promote the formation of immunosuppression and hypoxia of tumor microenvironment. Here, we review the progress on CAFs in regulation of immune cells and tumor immunity.

Key words： Neoplasms/immunology      Fibroblasts/immunology      Review     
Received: 14 April 2018      Published: 23 January 2019
CLC:  R392.12  
Corresponding Authors: WANG Qingqing     E-mail: 21607033@zju.edu.cn;wqq@zju.edu.cn
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LI Gaopeng
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WANG Qingqing
Cite this article:

LI Gaopeng,HE Jia,WANG Qingqing. Progress on cancer associated fibroblasts in tumor immunoregulation. J Zhejiang Univ (Med Sci), 2018, 47(5): 558-563.

URL:

http://www.zjujournals.com/med/10.3785/j.issn.1008-9292.2018.10.17     OR     http://www.zjujournals.com/med/Y2018/V47/I5/558


肿瘤相关成纤维细胞对肿瘤免疫调控作用的研究进展

肿瘤相关成纤维细胞（CAF）是肿瘤微环境中的重要组分，它通过分泌多种生长因子、趋化因子以及蛋白酶，调控肿瘤微环境中固有免疫细胞和适应性免疫细胞的募集和功能的发挥。此外，CAF分泌的胞外基质在塑造肿瘤微环境免疫抑制特性以及低氧形成的过程中也发挥着重要的促进作用。本文综述了肿瘤微环境中CAF对固有免疫细胞和适应性免疫细胞的浸润以及功能发挥的调控机制，同时针对以CAF为靶细胞进行药物开发的相关问题进行了展望，为进一步研究CAF的功能和临床应用提供科学依据。


关键词： 肿瘤/免疫学,  成纤维细胞/免疫学,  综述 
Fig 1 Effect of cancer associated fibroblasts on immune cells in tumor microenvironment
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