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J Zhejiang Univ (Med Sci)  2018, Vol. 47 Issue (5): 552-557    DOI: 10.3785/j.issn.1008-9292.2018.10.16
    
Roles of CCAAT enhancer binding protein α in acute myeloblastic leukemia
SHI Ting(),YE Xiujin*()
Department of Hematology, the First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310003, China
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Abstract  

The CCAAT enhancer binding protein α (C/EBP α:p42 and p30), which encoded by CCAAT enhancer binding protein α (C/EBPα) gene, plays a pretty crucial role in the regulation of myeloid hematopoiesis.The disorder of CEBPA gene expression is an pivotal mechanism of acute myeloid leukemia (AML). The result of uncontrolled expression of C/EBP α gene is the over-expression of p30 and the incomplete loss of p42, both of which contribute to the occurrence of AML. Restoring the expression ratio of C/EBP α such as over-expression of p42 or blocking the carcinogenic pathway of p30 seems to be important for the treatment of AML caused by such causes. In order to better guide medical decision-making, this article reviews research progress on C/EBPα in the pathogenesis of AML.



Key wordsCCAAT enhancer binding protein α      Leukemia, myeloid, acute      Gene expression      Mutation      Review     
Received: 18 April 2018      Published: 23 January 2019
CLC:  R733.71  
Corresponding Authors: YE Xiujin     E-mail: 1626293723@qq.com;yxjsunny@zju.edu.cn
Cite this article:

SHI Ting,YE Xiujin. Roles of CCAAT enhancer binding protein α in acute myeloblastic leukemia. J Zhejiang Univ (Med Sci), 2018, 47(5): 552-557.

URL:

http://www.zjujournals.com/med/10.3785/j.issn.1008-9292.2018.10.16     OR     http://www.zjujournals.com/med/Y2018/V47/I5/552


CCAAT增强子结合蛋白α与急性髓细胞白血病的发生

CCAAT增强子结合蛋白α(C/EBPα)在髓系造血过程中起着重要的调控作用,其基因表达失调是急性髓细胞白血病(AML)发生的重要机制。C/EBPα基因表达失控的结局是p30过表达和p42不完全丧失,两者均促使AML的发生。因此,恢复C/EBPα表达比例,过表达p42或阻断p30致癌通路是治疗此类原因所致AML的重要途径。本文回顾了近年来关于C/EBPα表达失调及其两种蛋白体在AML发病机制中的研究进展。


关键词: CCAAT增强子结合蛋白α,  白血病, 髓样, 急性,  基因表达,  突变,  综述 
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