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J Zhejiang Univ (Med Sci)  2018, Vol. 47 Issue (5): 493-498    DOI: 10.3785/j.issn.1008-9292.2018.10.08
    
Roles of astrocytes in cerebral infarction and related therapeutic strategies
YE Jianyu1(),SUN Ziyu1,HU Weiwei2,*()
1. College of Pharmaceutical Sciences, Zhejiang University, Hangzhou 310058, China
2. Department of Pharmacology, School of Basic Medical Sciences, Zhejiang University School of Medicine, Hangzhou 310058, China
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Abstract  

Astrocytes are the most abundant cells in the central nervous system and play significant roles in normal brain. With cerebral infarction, astrocytes are activated as reactive astrocytes and form glial scars, which play an essential part in brain injury. According to their roles in neuroprotection after cerebral infarction, regulation of scar formation, nerve regeneration, maintenance of blood-brain barrier, promotion of angiogenesis and immune response, scholars have proposed a variety of therapeutic strategies based on targeting astrocytes. This article reviews the research progress on the changes in astrocyte signaling pathways before and after cerebral infarction and the related therapeutic strategies.



Key wordsBrain infarction      Astrocytes      Cicatrix/etiology      Review     
Received: 30 May 2018      Published: 23 January 2019
CLC:  R743  
Corresponding Authors: HU Weiwei     E-mail: 3150103114@zju.edu.cn;huww@zju.edu.cn
Cite this article:

YE Jianyu,SUN Ziyu,HU Weiwei. Roles of astrocytes in cerebral infarction and related therapeutic strategies. J Zhejiang Univ (Med Sci), 2018, 47(5): 493-498.

URL:

http://www.zjujournals.com/med/10.3785/j.issn.1008-9292.2018.10.08     OR     http://www.zjujournals.com/med/Y2018/V47/I5/493


星形胶质细胞在脑梗死中的作用及相关治疗策略

星形胶质细胞是中枢神经系统中最丰富的细胞,在大脑正常生理过程中扮演重要角色。脑梗死发生后,星形胶质细胞激活成为反应性星形胶质细胞,并形成胶质瘢痕,在脑损伤过程中发挥重要作用。根据其在脑梗死后神经保护、调节瘢痕形成、神经再生、维持血脑屏障和促进血管生成、调节免疫应答等方面的作用,学者们提出了靶向星形胶质细胞的多种治疗策略。本文就反应性星形胶质细胞在脑梗死后发挥的积极作用以及相应的治疗策略作一综述。


关键词: 脑梗死,  星形细胞,  瘢痕/病因学,  综述 
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