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J Zhejiang Univ (Med Sci)  2018, Vol. 47 Issue (2): 169-173    DOI: 10.3785/j.issn.1008-9292.2018.04.10
    
Influencing factors for high level measles antibodies among 6-15 year-old children in Zhejiang province
YAN Rui1(),HE Hanqing1,*(),ZHOU Yang1,DENG Xuan1,TANG Xuewen1,XIE Shuyun1,FENG Yan2
1. Department of Immunization Program, Zhejiang Provincial Center for Disease Control and Prevention, Hangzhou 310051, China
2. Department of Microorganism, Zhejiang Provincial Center for Disease Control and Prevention, Hangzhou 310051, China
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Abstract  

Objective: To determine measles antibody levels and influencing factors among children aged 6 to 15 years in Zhejiang province. Methods: Blood samples were collected from 2069 children aged 6 to 15 years in Changxing county (Huzhou) and Liandu district (Lishui) of Zhejiang province. Serum level of measles IgG antibody was measured using ELISA, and 800 mIU/mL was applied as the cut-off point of high antibody level. Chi-square or trend Chi-square test was used to analyze difference in positive rates of high antibody level among children with different characters, and the factors related to high antibody level in the vaccinated children were analyzed using multivariate logistic regression. Results: Among 2069 subjects, positive rate of high measles antibody level was 36.06% (746/2069). Multivariate logistic regression showed that the high measles antibody level was significantly associated with age of children and the age of first measles vaccine inoculation. The positive rate of high measles antibody level decreased with age(OR=0.866, 95%CI:0.830-0.904, P < 0.01), and the positive rate in children whose first vaccination at ≥ 12 months of age was higher than those whose first vaccination at 8 months of age(OR=0.633, 95%CI:0.498-0.805, P < 0.01). Conclusion: In order to obtain high measles antibody level and to maintain high levels of population immune barrier, it is suggested that first dose of vaccination can be appropriately delayed in low epidemic areas, and elder children should have timely catch-up vaccination.



Key wordsAntibodies, viral/analysis      Measles/prevention & control      Measles vaccine/therapeutic use      Vaccination      Immunoglobulin G/analysis      Age      Enzyme-linked immunosorbent assay     
Received: 26 February 2018      Published: 24 July 2018
CLC:  R511.1  
Corresponding Authors: HE Hanqing     E-mail: ryan@cdc.zj.cn;hanqinghe@cdc.zj.cn
Cite this article:

YAN Rui,HE Hanqing,ZHOU Yang,DENG Xuan,TANG Xuewen,XIE Shuyun,FENG Yan. Influencing factors for high level measles antibodies among 6-15 year-old children in Zhejiang province. J Zhejiang Univ (Med Sci), 2018, 47(2): 169-173.

URL:

http://www.zjujournals.com/med/10.3785/j.issn.1008-9292.2018.04.10     OR     http://www.zjujournals.com/med/Y2018/V47/I2/169


浙江省6~15岁儿童高浓度抗麻疹病毒抗体影响因素分析

目的: 了解浙江省6~15岁儿童抗麻疹病毒高浓度抗体阳性率及其影响因素,为制订麻疹防控策略提供科学依据。方法: 采集浙江省湖州市长兴县和丽水市莲都区2069名6~15岁儿童的血清,ELISA法定量检测麻疹IgG抗体水平,抗体浓度800 mIU/mL以上为达到高浓度抗体。利用χ2检验或趋势χ2检验比较不同特征人群麻疹高浓度抗体的阳性率;多因素logistic回归分析麻疹疫苗接种儿童麻疹高浓度抗体的影响因素。结果: 2069名调查对象中,麻疹高浓度抗体阳性率为36.06%(746/2069)。多因素logistic回归分析结果显示,年龄和起始接种月龄是麻疹疫苗接种儿童麻疹高浓度抗体的影响因素。随着年龄的增长,高浓度抗体阳性率呈现下降趋势(OR:0.866,95%CI:0.830~0.904,P < 0.01);12月龄及以上接种者的高浓度抗体阳性率高于8月龄接种者(OR:0.633,95%CI:0.498~0.805,P < 0.01)。结论: 为维持高水平人群免疫屏障,建议疫情低发地区可以适当延迟麻疹疫苗首剂次接种时间,并对于大龄儿童适时进行补种。


关键词: 抗体, 病毒/分析,  麻疹/预防和控制,  麻疹疫苗/治疗应用,  接种,  免疫球蛋白G/分析,  年龄,  酶联免疫吸附测定 
[n(%)]
特征 n 高浓度抗体
χ2检验或趋势χ2检验,*P<0.05;* *P<0.01.
性别    男 1068 365(34.18)
    女 1001 381(38.06)
年龄(岁)**    6 153 75(49.02)
    7 280 131(46.79)
    8 242 113(46.69)
    9 207 95(45.89)
    10 206 64(31.07)
    11 206 72(34.95)
    12 201 43(21.39)
    13 188 45(23.94)
    14 217 50(23.04)
    15 169 58(34.32)
户籍*    本县区 1626 594(36.53)
    本市其他县区 348 117(33.62)
    本省其他市 22 4(18.18)
    外省 62 31(50.00)
低出生体质量    是 44 18(40.91)
    否 1987 720(36.24)
父亲文化程度    小学及以下 215 80(37.21)
    中学或中专技校 1574 562(35.71)
    大学及以上 237 91(38.40)
母亲文化程度    小学及以下 258 88(34.11)
    中学或中专技校 1555 571(36.72)
    大学及以上 214 76(35.51)
麻疹病史    有 28 8(28.57)
    无 2041 738(36.16)
接种起始月龄**    8~<9月龄 907 297(32.75)
    9~<12月龄 327 137(41.90)
    ≥12月龄 527 229(43.45)
免疫史**    0剂次 308 83(26.95)
    1剂次 293 92(31.40)
    2剂次 986 386(39.15)
    3剂次及以上 482 185(38.38)
Tab 1 High protective antibody levels of measles in children with different characters
因素 回归系数 标准误 Wald值 P OR值(95% CI)
性别(男) -0.162 0.103 2.486 >0.05 0.851(0.696~1.040)
年龄 -0.144 0.022 42.994 <0.01 0.866(0.830~0.904)
户籍(参照“本县区”)    本市其他县区 -0.080 0.148 0.294 >0.05 0.923(0.690~1.234)
    本省其他市 -1.190 0.642 3.433 >0.05 0.304(0.086~1.071)
    外省 0.410 0.290 2.009 >0.05 1.507(0.855~2.659)
低出生体质量 0.416 0.348 1.429 >0.05 1.517(0.766~3.003)
父亲文化程度(参照“大学及以上”)    小学及以下 -0.028 0.267 0.011 >0.05 0.972(0.576~1.641)
    中学或中专技校 -0.130 0.201 0.421 >0.05 0.878(0.592~1.301)
母亲文化程度(参照“大学及以上”)    小学及以下 0.172 0.267 0.414 >0.05 1.187(0.703~2.004)
    中学或中专技校 0.162 0.213 0.578 >0.05 1.175(0.775~1.783)
麻疹病史 0.148 0.446 0.110 >0.05 1.159(0.483~2.781)
接种起始月龄(参照“≥12月龄”)    8~<9月龄 -0.457 0.122 13.960 <0.01 0.633(0.498~0.805)
    9~<12月龄 -0.156 0.154 1.022 >0.05 0.855(0.632~1.158)
免疫史(参照“3剂次及以上”)    1剂次 -0.138 0.177 0.607 >0.05 0.872(0.617~1.232)
    2剂次 0.041 0.124 0.112 >0.05 1.042(0.818~1.328)
Tab 2 Risk factors for high protective antibody levels of measles in vaccinated children
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