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Journal of ZheJiang University(Medical Science)  2017, Vol. 46 Issue (5): 563-569    DOI: 10.3785/j.issn.1008-9292.2017.10.18
    
Research progress on genes mutations related to sulfa drug resistance in Pneumocystis jirovecii
WANG Mengyan, ZHU Biao
State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, Department of Infection Diseases, the First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310003, China
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Abstract  

Pneumocystis jirovecii pneumonia is an opportunistic infection among immunocompromised people. Studies have found that the increased resistance to sulfa drugs of Pneumocystis jirovecii may be associated with the mutation of dihydropteroate synthase (DHPS) gene and dihydrofolate reductase (DHFR) genes, but the mechanism is still unclear. The mutation of DHPS and DHFR genes may be the result of sulfa drugs selection or spontaneous genetic polymorphism, and it can be acquired from person-to-person transmission. This article reviews the cause, molecular epidemiology of DHPS and DHFR gene mutation, and the relationship between DHPS and DHFR gene mutation and clinical outcomes.



Key wordsDrug resistance,bacterial/genetics      Pneumonia,pneumocystis/physiopathology      Tetrahydrofolate dehydrogenase      Sulfonamides/pharmacology      Genes      Mutation      Review     
Received: 20 February 2017      Published: 25 October 2017
CLC:  R379.9  
Cite this article:

WANG Mengyan, ZHU Biao. Research progress on genes mutations related to sulfa drug resistance in Pneumocystis jirovecii. Journal of ZheJiang University(Medical Science), 2017, 46(5): 563-569.

URL:

http://www.zjujournals.com/xueshu/med/10.3785/j.issn.1008-9292.2017.10.18     OR     http://www.zjujournals.com/xueshu/med/Y2017/V46/I5/563


耶氏肺孢子菌对磺胺类药物耐药相关基因突变的研究进展

肺孢子菌肺炎是由耶氏肺孢子菌引起的,发生在免疫功能低下人群中的机会性感染。大量证据表明,耶氏肺孢子菌对磺胺类药物耐药性增加与二氢叶酸合成酶(DHPS)基因和二氢叶酸还原酶(DHFR)基因突变有关,但具体机制尚不清楚。DHPSDHFR基因突变增加可能是药物选择性压力所致,也可能是耶氏肺孢子菌基因多态性自然发展和传播的结果。本文对耶氏肺孢子菌DHPSDHFR基因突变产生的原因、分子流行病学研究进展及其与临床结局的关系进行了综述。


关键词: 肺囊虫性/病理生理学,  突变,  基因,  四氢叶酸脱氢酶,  综述,  肺炎,  磺胺类/药理学,  抗药性,  细菌/遗传学 
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