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Journal of ZheJiang University(Medical Science)  2017, Vol. 46 Issue (4): 449-453    DOI: 10.3785/j.issn.1008-9292.2017.08.17
Progress on the study of NLRP3 inflammasome in autoinflammatory diseases of children
LI Yandie, LU Meiping
Department of Rheumatology Immunology & Allergy, Children's Hospital, Zhejiang University School of Medicine, Hangzhou 310003, China
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Autoinflammatory diseases (AID) in childhood is one of refractory diseases, whose pathogenesis is not completely clear. In recent years, a large number of studies have shown that NLRP3 inflammasome plays an important role in the development of AIDs in children. Inflammasome is a cytosolic multiprotein complex that can activate cysteinyl aspartate-specific protease-1 (caspase-1), to further promote the maturation and secretion of proinflammatory cytokines IL-1β and IL-18 as well as pyroptosis and regulate innate immune response. IL-1 receptor antagonist (Anakinra) and IL-1β monoclonal antibody (Canakinumab) have good therapeutic effects in children with AIDs. This article reviews the research progress of NLRP3 inflammasome in the pathogenesis of autoinflammatory diseases.

Key wordsMultiprotein complexes      Autoimmune diseases      Interleukin-1 beta      Chromosome disorders      Review     
Received: 28 April 2017      Published: 25 August 2017
CLC:  R725.9  
Cite this article:

LI Yandie, LU Meiping. Progress on the study of NLRP3 inflammasome in autoinflammatory diseases of children. Journal of ZheJiang University(Medical Science), 2017, 46(4): 449-453.

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关键词: 多蛋白复合物,  自身免疫疾病,  白细胞介素1β,  染色体障碍,  综述 

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