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Journal of ZheJiang University(Medical Science)  2017, Vol. 46 Issue (3): 321-327    DOI: 10.3785/j.issn.1008-9292.2017.06.16
The involvement of galectin-1 in implantation and pregnancy maintenance at the maternal-fetal interface
TANG Minyue, ZHU Yimin
Department of Reproductive Endocrinology, Women's Hospital, Zhejiang University School of Medicine, Hangzhou 310006, China
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As a member of galectins family, galectin-1(Gal-1)is widely expressed in tissues and cells, and participates in a variety of physiological and pathological processes, such as cell adhesion, proliferation, apoptosis and inflammatory reaction. Recently, it has been found that Gal-1 is highly expressed at the maternal-fetal interface and plays important roles in trophoblast cell proliferation, differentiation and invasion, endometrial receptivity, placental angiogenesis and maternal-fetal immune tolerance. In this review, we outline the expression of Gal-1 at the maternal-fetal interface and the involvement of Gal-1 in embryo implantation and pregnancy maintenance, to provide novel insights for the early diagnosis, prognostic assessment and treatment of early pregnancy loss and pregnancy-related diseases.

Key wordsGalectin 1      Pregnancy      Embryo implantation      Placenta      Trophoblasts/cytology      Immune tolerance      Review     
Received: 14 August 2016      Published: 25 June 2017
CLC:  R714  
Cite this article:

TANG Minyue, ZHU Yimin. The involvement of galectin-1 in implantation and pregnancy maintenance at the maternal-fetal interface. Journal of ZheJiang University(Medical Science), 2017, 46(3): 321-327.

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关键词: 半乳糖凝集素1,  妊娠,  胚胎植入,  胎盘,  滋养层/细胞学,  免疫耐受,  综述 

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