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Journal of ZheJiang University(Medical Science)  2017, Vol. 46 Issue (3): 300-304    DOI: 10.3785/j.issn.1008-9292.2017.06.13
    
Long-term effects of polycystic ovary syndrome on the offspring
SHEN Dan1,2, WANG Fangfang1, JIANG Zhou3, QU Fan1
1. Department of Traditional Chinese Medicine, Women's Hospital, Zhejiang University School of Medicine, Hangzhou 310006, China;
2. Department of Pediatrics, Hangzhou Red Cross Hospital, Hangzhou 310003, China;
3. Department of NICU, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou 310016, China
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Abstract  

Polycystic ovary syndrome (PCOS) is an endocrine disorder with reproductive dysfunction and abnormal metabolic syndrome. However, its etiology is unknown yet. Androgen hypersecretion is one of the main features of PCOS. It has been found that PCOS has various effects on the offspring in reproductive, metabolic and nervous systems, including:increasing secretion of gonadotropin-releasing hormone and luteinizing hormone, ovarian morphological changes and abnormal secretion of sex hormones, leading to disorders of lipid and glucose metabolism, and increasing the risks of depression and autism. However, there is still lack of direct evidence, and more studies should be conducted on the underlying mechanism in future.



Key wordsPolycystic ovary syndrome      Androgens      Filial generation      Autism      Depressive disorder      Review     
Received: 30 December 2016      Published: 25 June 2017
CLC:  R711.75  
  R722  
Cite this article:

SHEN Dan, WANG Fangfang, JIANG Zhou, QU Fan. Long-term effects of polycystic ovary syndrome on the offspring. Journal of ZheJiang University(Medical Science), 2017, 46(3): 300-304.

URL:

http://www.zjujournals.com/xueshu/med/10.3785/j.issn.1008-9292.2017.06.13     OR     http://www.zjujournals.com/xueshu/med/Y2017/V46/I3/300


多囊卵巢综合征患者子代发生的远期改变

多囊卵巢综合征(PCOS)是一种生殖功能障碍与代谢异常并存的内分泌紊乱综合征,病因不明。雄激素分泌过多是PCOS的主要特征之一。PCOS子代生殖系统、代谢系统、神经精神系统均有不同程度的远期改变。PCOS子代有促性腺激素释放激素和促性腺激素分泌增加、卵巢形态改变、性激素分泌异常的表现,脂肪和糖代谢紊乱现象,子代抑郁症及自闭症的风险增加,但是目前缺乏直接相关的证据,相关机制仍需进一步研究。


关键词: 多囊卵巢综合征,  雄激素类,  子代,  自闭症,  抑郁症,  综述 

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