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Journal of ZheJiang University(Medical Science)  2016, Vol. 45 Issue (6): 655-660    DOI: 10.3785/j.issn.1008-9292.2016.11.16
Research progress on the effect of glucocorticoid receptor signaling pathways in bladder cancer
FENG Sheng1,2, CHEN Jijun2, ZHENG Yichun2
1. Department of Urology, the First Affiliated Hospital, Zhejiang Chinese Medical University, Hangzhou 310006, China;
2. Department of Urology, the Second Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou 310009, China
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Glucocorticoid receptor (GR) is identified as a member of nuclear receptor family. To exert its biological action, the ligand bound GR is translocated from the cytoplasm into the nucleus by regulating transcriptional signals of related genes. In clinical practice, the effects of glucocorticoid are often mediated by GR signaling pathways. An increasing number of studies have indicated that GR signaling pathways play an essential role in the proliferation, invasion and prognosis of bladder cancer. Meanwhile, the new-generation selective GR activator improves its anti-tumor effects, and at the same time reduces the adverse reactions of hormones, which probably raises the prospect for the treatment of bladder cancer.

Key wordsUrinary bladder neoplasms/drug therapy      Receptors, glucocorticoid/therapeutic use      Signal transduction      Transcription, genetic      Review     
Received: 20 June 2016     
CLC:  R737.14  
Cite this article:

FENG Sheng, CHEN Jijun, ZHENG Yichun. Research progress on the effect of glucocorticoid receptor signaling pathways in bladder cancer. Journal of ZheJiang University(Medical Science), 2016, 45(6): 655-660.

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关键词: 膀胱肿瘤/药物疗法,  受体,  糖皮质激素/治疗应用,  信号传导,  转录,  遗传,  综述 
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