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Journal of ZheJiang University(Medical Science)  2016, Vol. 45 Issue (5): 544-549    DOI: 10.3785/j.issn.1008-9292.2016.09.15
Reasearch progress on the role of neutrophils in asthma
LI Tingting, KE Yuehai, CHENG Hongqiang
Department of Pathology and Pathophysiology, Zhejiang University School of Medicine, Hangzhou 310058, China
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Asthma is a phenotypically heterogeneous chronic disease of the airways. Studies have found that neutrophils are crucial to airway inflammation in acute asthma, persistent asthma, particularly in asthma of poor response to glucocorticoid treatment. The role of neutrophils in development of bronchial asthma is complex, as they can release a potent source of cytokines and inflammatory mediators participating in asthma. Differing from eosinophilic inflammatory asthma, neutrophilic inflammatory asthma is not depend on helper T (Th)2 cells, but may be related to Th1 and Th17 cells. This review highlights the role of neutrophils in the development of asthma, and the treatment of neutrophilic asthma with biological agents and novel small molecules.

Key wordsAsthma/physiopathology      Neutrophils/physiology      Helper T cell      Review     
Received: 25 June 2016      Published: 25 September 2016
CLC:  R562  
Cite this article:

LI Tingting, KE Yuehai, CHENG Hongqiang. Reasearch progress on the role of neutrophils in asthma. Journal of ZheJiang University(Medical Science), 2016, 45(5): 544-549.

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关键词: 哮喘/病理生理学,  中性白细胞/生理学,  辅助性T细胞,  综述 
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