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Journal of ZheJiang University(Medical Science)  2016, Vol. 45 Issue (2): 170-178    DOI: 10.3785/j.issn.1008-9292.2016.03.10
MicroRNAs: a type of novel regulative factor for intervertebral disc degeneration
WANG Cheng1,2, WANG Wenjun2, YANG Wei2, YU Xiaohua3, YAN Yiguo2, ZHANG Jian4, JIANG Zhisheng1
1. Institute of Cardiovascular Disease, Key Laboratory for Arteriosclerology of Hunan Province, University of South China, Hengyang 421001, China;
2. Department of Spine Surgery, the First Affiliated Hospital, University of South China, Hengyang 421001, China;
3. Life Science Research Center, University of South China, Hengyang 421001, China;
4. Department of Hand and Micro-surgery, the First Affiliated Hospital, University of South China, Hengyang 421001, China
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Intervertebral disc degeneration (IDD) is one of major causes for intervertebral disc degenerative diseases, and patients with IDD usually suffer from serious low back pain. The current treatments for patients with IDD only relieve the clinical symptom rather than restore biological balance of IDD, leading to inadequate and unsatisfactory results. MicroRNAs (miRNAs) are endogenous, non-coding, single-stranded RNA molecules, which regulate the gene expression at the post-transcription levels. Research evidences support the involvement of miRNAs in many biological processes, such as lipid metabolism, apoptosis, differentiation and organ development. Accumulating evidences indicate that the expressions of miRNAs change significantly in degenerative tissues. In addition, dysregulated miRNAs contribute to multiple pathological process of IDD, including proliferation and apoptosis of nucleus pulposus and extracellular matrix components, inflammatory response and cartilage endplates degeneration. In this review article, we summarize the expression profiles and roles of miRNAs in IDD, which may provide a novel strategy of biological therapy for the disease.

Key wordsMicroRNAs      Gene expression      Intervertebral disk/pathology      Extracellular matrix      Cell proliferation      Apoptosis      Inflammation/etiology      Intervertebral disk displacement/pathology      Review     
Received: 12 October 2015     
CLC:  R68  
Cite this article:

WANG Cheng, WANG Wenjun, YANG Wei, YU Xiaohua, YAN Yiguo, ZHANG Jian, JIANG Zhisheng. MicroRNAs: a type of novel regulative factor for intervertebral disc degeneration. Journal of ZheJiang University(Medical Science), 2016, 45(2): 170-178.

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关键词: 微RNAs,  基因表达,  椎间盘/病理学,  细胞外基质,  细胞增殖,  细胞凋亡,  炎症/病因学,  椎间盘移位/病理学,  综述 

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