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Journal of ZheJiang University(Medical Science)  2015, Vol. 44 Issue (6): 689-702    DOI: 10.3785/j.issn.1008-9292.2015.11.15
    
Efficacy of family intervention in management of schizophrenic patients in China: a meta-analysis
CHEN Nan1, AN Jing-huan1, YANG Min1,2, LIU Yuan-yuan1
1. Department of Epidemiology and Health Statistics, West China School of Public Health, Sichuan University, Chengdu 610041, China;
2. West China Research Center for Rural Health Development, Chengdu 610041, China
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Abstract  

Objective: To assess the efficacy of family intervention in management of schizophrenic patients in China. Methods: Chinese databases CNKI, VIP, WANFANG, CBM and English databases OVID Medline, Science Direct, Web of science, EBSCO were searched systematically from inception to January 2015. Quantitative and empirical studies on the outcomes of social disability screening scale (SDSS), brief psychiatric rating scale (BPRS) and positive and negative syndrome scale (PANSS) of family intervention for Chinese schizophrenic patients were selected. The effect size was derived from the standardized mean difference (SMD), and meta-analysis was conducted to compare effects of family intervention by intervention types, time of intervention, durations of illness and severity of schizophrenia.Results: The study included 57 articles that met inclusion criteria. SDSS and PANSS scores revealed that the effect was positively associated with the length of intervention time (P<0.0001, P=0.0025); the effect of single family intervention was better than that of combined single and multiple family intervention (P<0.0001, P=0.0131); the effect was better for patients with severe conditions than those with less severe conditions (P<0.0001, P=0.0280). The SDSS showed that the effect was better for patients with shorter disease duration (P<0.0001). Conclusion: The results suggest that the long single family intervention would benefit to schizophrenic patients, particularly for severe patients with short disease duration.



Key wordsFamily      Schizophrenia/prevention &      control      Evaluation studies      Intervention studies      Meta-analysis as topic     
Received: 30 April 2015     
CLC:  R749.3  
Cite this article:

CHEN Nan, AN Jing-huan, YANG Min, LIU Yuan-yuan. Efficacy of family intervention in management of schizophrenic patients in China: a meta-analysis. Journal of ZheJiang University(Medical Science), 2015, 44(6): 689-702.

URL:

http://www.zjujournals.com/xueshu/med/10.3785/j.issn.1008-9292.2015.11.15     OR     http://www.zjujournals.com/xueshu/med/Y2015/V44/I6/689


中国精神分裂症患者不同家庭干预措施效果比较的meta分析

目的:对中国精神分裂症患者采取家庭干预的研究文献进行综合回顾和系统评价,比较不同条件下家庭干预效果的差异。方法:在中国知网、维普、万方、中国生物医学文献数据库四大中文数据库及OVID Medline、Science Direct、Web of Science、EBSCO四大英文数据库中,检索各数据库建库至2015年1月为止使用社会功能缺陷筛选量表(SDSS)、简明精神病(科)量表(BPRS)、阳性与阴性症状量表(PANSS)研究中国精神分裂症患者家庭干预效果的文献,以标准化加权均数差(SMD)作为效应量,采用meta分析比较不同干预时间、不同干预类型、对不同病程和不同严重程度的精神分裂症患者的家庭干预效果差异。结果:共纳入57篇符合标准的文献。SDSS、PANSS分析结果显示:①干预时间越长干预效果越好(P<0.0001、P=0.0025);②单独家庭干预比多个家庭合并单独家庭干预的效果更明显(P<0.0001、 P=0.0131);③干预对于病情较重患者效果较好(P<0.0001、P=0.0280)。SDSS量表还显示家庭干预对于病程短的患者效果更好(P<0.0001)。结论:家庭干预更适合病程较短的精神分裂症患者,干预应实施较长时间;单独家庭干预更有利于患者阴性症状的改善和社会功能的康复,且对于病情较轻患者的阴性症状改善效果更好。


关键词: 家庭,  精神分裂症/预防和控制,  评价研究,  干预性研究,  Meta分析(主题) 
[[1]]   李思远,董碧蓉,李 峻. 初诊精神分裂症患者的循证治疗[J]. 中国全科医学,2012, 15(33):3819-3822. LI Si-yuan, DONG Bi-rong, LI Jun. Evidence-based therapy for a patient with first-episode schizophrenia[J]. Chinese General Practice, 2012, 15(33):3819-3822. (in Chinese)
[[2]]   项玉涛. 促进精神分裂症患者回归社会的心理社会干预[J]. 国外医学(精神病学分册), 2002, 29(1):31-34. XIANG Yu-tao. The psychosocial intervention promoting the reintegration of schizophrenia[J]. Foreign Medical Sciences (Section of Psychiatry), 2002, 29(01):31-34.(in Chinese)
[[3]]   PILLING S, BEBBINGTON P, KUIPERS E, et al. Psychological treatments in schizophrenia: I. meta-analysis of family intervention and cognitive behaviour therapy[J]. Psychological Medicine, 2002, 32(5):763-782.
[[4]]   张明园. 精神科评定量表手册[M]. 长沙: 湖南科学技术出版社,1998:163-166. ZHANG Ming-yuan. Psychiatric rating scale manual[M]. Changsha: Hunan Scientific and Technical Publishers, 1998: 163-166. (in Chinese)
[[5]]   张明园. 简明精神病量表(BPRS)[J]. 上海精神医学, 1984, 2: 58-60. ZHANG Ming-yuan. The brief psychiatric rating scale (BPRS)[J]. Shanghai Archives of Psychiatry,1984, 02:58-60. (in Chinese)
[[6]]   汪向东,王希林,马 弘. 心理卫生评定量表手册[M]. 北京:中国心理卫生杂志社,1999:263-266. WANG Xiang-dong, WANG Xi-lin, MA Hong. Mental health rating scale manual [M]. Beijing: Chinese Mental Health Journal,1999:263-266. (in Chinese)
[[7]]   王善澄. 心理社会干预进展[J]. 上海精神医学,2000,12(z1):41-43, 12. WANG Shan-cheng. Advances in psychosocial intervention[J]. Shanghai Archives of Psychiatry, 2000, 12(z1):41-43, 12. (in Chinese)
[[8]]   徐 逸,陆 峥. 精神分裂症患者家庭功能的评估及家庭干预对疾病的影响[J]. 同济大学学报(医学版),2013,34(01):120-124. XU Yi, LU Zheng. Assessment of family functioning in patients with schizophrenia and the effect of family intervention on disease outcome[J]. Journal of Tongji University (Medical Science), 2013, 34(01):120-124. (in Chinese)
[[9]]   MARI J D J, STREINER D L. An overview of family interventions and relapse on schizophrenia: meta-analysis of research findings[J]. Psychological Medicine,1994, 24(3):565-578.
[[10]]   中华医学会精神科分会. CCMD-3中国精神障碍分类与诊断标准(第3版)[M]. 济南:山东科学技术出版社,2001:83-91. Psychiatric Branch of Chinese Association. CCMD-3 China classification and diagnostic criteria for mental disorders (3rd ed)[M]. Jinan: Shandong Scientific and Technical Publishers,2001:83-91. (in Chinese)
[[11]]   世界卫生组织. ICD-10精神与行为障碍分类[M]. 北京:人民卫生出版社,1993:97-106. World Health Organization. ICD-10 classification of mental and behavioural disorders[M]. Beijing: People's Medical Publishing House,1993:97-104. (in Chinese)
[[12]]   刘 琳,许 坤,岳淑英,等. 认知领悟治疗对精神分裂症患者康复效果的随访研究[J]. 护理管理杂志,2005,5(1):15-18. LIU Lin, XU Kun, YUE Shu-ying, et al. The follow-up study on the rehabilitation effect of cognition insight therapy in patients with schizophrenia[J]. Journal of Nursing Administration, 2005, 5(1):15-18. (in Chinese)
[[13]]   邱传谦,曾昭祥,李志成. 医生实施家庭干预对社区精神分裂症患者社会功能及生活质量的影响:半年随访评估[J]. 中国临床康复,2005,9(12):75-77. QIU Chuan-qian, ZENG Zhao-xiang, LI Zhi-cheng. Influence of family intervention by physician on the social function and quality of life in community schizophrenic patients: a follow-up for half a year[J]. Chinese Journal of Clinical Rehabilitation,2005,9(12):75-77. (in Chinese)
[[14]]   谭 斌,向恩平,何宇芬. 精神分裂症患者社区防治效果及其家庭经济负担评估[J]. 中国临床康复,2005,9(28):24-26. Tan Bin, Xiang En-ping, HE Yu-fen. Effect of community prevention and treatment in patients with schizophrenia and their family economic burden[J]. Chinese Journal of Clinical Rehabilitation, 2005, 9(28):24-26. (in Chinese)
[[15]]   于得霞,徐建国,沈振明,等. 中医心理教育对精神分裂症康复的随访研究[J]. 神经疾病与精神卫生,2005,5(4):280-281. YU De-xia, XU Jian-guo, SHEN Zhen-ming, et al. The follow-up study on the rehabilitation effect of traditonal Chinese medicine psychological education in patients with schizophrenia[J]. Nervous Diseases and Mental Health, 2005, 5(4):280-281. (in Chinese)
[[16]]   杨凤莲,解昌国. 家庭护理干预对康复期精神分裂症患者预后的影响[J]. 中国全科医学,2006,9(13):1104-1105. YANG Feng-lian, XIE Chang-guo. Effect of family nursing intervention on the prognosis of outpatients with schizophrenia[J]. Chinese General Practice, 2006, 9(13):1104-1105. (in Chinese)
[[17]]   杨长虹,贾金鼎,张艳丽. 心理干预对精神分裂症的疗效和家庭环境的影响[J]. 中国健康心理学杂志,2006,14(4):437-439. YANG Chang-hong, JIA Jin-ding, ZHANG Yan-li. Effect of the mental interference on the schizophrenia and family environment[J]. China Journal of Health Psychology, 2006, 14(4):437-439.
[[18]]   张瑞芬,夏娟静,盛 玲,等. 家庭干预前后慢性精神分裂症患者家庭支持与社会功能的相关性研究[J]. 现代护理,2006,12(22):2138-2139. ZHANG Rui-fen, XIA Juan-jing, SHENG Ling, et al. Study on the correlation between the family support and the social function of patients with chronic schizophrenia before and after the family intervention[J]. Modern Nursing, 2006,12(22):2138-2139. (in Chinese)
[[19]]   刘 琳,岳淑英,卢世臣,等. 综合护理干预对精神分裂症患者社会技能及生活质量的影响[J]. 护理学杂志,2006,21(13):10-13. LIU Lin, YUE Shu-yin, LU Shi-chen, et al. Effect of comprehensive nursing interventions on social functions and quality of life of patients with schizophrenia[J]. Journal of Nursing Science, 2006, 21(13):10-13. (in Chinese)
[[20]]   张明廉,袁国桢,倪素琴,等. 家庭干预对精神分裂症患者临床疗效的对照研究[J]. 中国神经精神疾病杂志,2006,32(6):550-552. ZHANG Ming-lian, YUAN Guo-zhen, NI Su-qin, et al. A comparative study of family intervention on clinical efficacy in patients with schizophrenia[J]. Chinese Journal of Nervous and Mental Diseases, 2006, 32(6):550-552. (in Chinese)
[[21]]   戴明华,刘方莹,范继美. 早期综合干预对首发精神分裂症病人预后影响的研究[J]. 护理研究,2007,21(26):2393-2394. DAI Ming-hua, LIU Fang-ying, FAN Ji-mei, et al. A study on influence of early comprehensive interventions on prognosis of incipient schizophrenia patients[J]. Chinese Nursing Research, 2007, 21(26):2393-2394. (in Chinese)
[[22]]   龚传鹏,张建军,郑 刚,等. 家庭综合干预对精神分裂症患者临床康复的作用[J]. 中国行为医学科学,2007,16(10):903-905. GONG Chuan-peng, ZHANG Jian-jun, ZHENG Gang, et al. Three-year follow-up study of family synthetically intervention for community family bed patients with schizophrenia[J]. Chinese Journal of Behavioral Medical Science, 2007, 16(10):903-905. (in Chinese)
[[23]]   刘 娜. 稳定期精神分裂症的综合治疗效果及相关因素分析[D]. 上海:同济大学,2007. LIU Na. Comprehensive treatment of schizophrenia and related factors stability analysis[D]. Shanghai: Tongji University, 2007. (in Chinese)
[[24]]   王荣会,张 静,郭艳峤. 社区家庭综合干预对精神分裂症患者康复的效果[J]. 现代护理,2007,13(17):1653-1654. WANG Rong-hui, ZHANG Jing, GUO Yan-qiao. Effect of community integrated family intervention on the rehabilitation of patients with schizophrenia[J]. Modern Nursing, 2007, 13(17):1653-1654. (in Chinese)
[[25]]   代素平,郭 平,樊凌姿. 家庭心理干预对康复期精神分裂症患者预后的影响[J]. 中国健康心理学杂志,2008,16(1):42-43. DAI Su-ping, GUO Ping, FAN Ling-zi. Effect of familly mental intervention on the prognosis of outpatients with schizophrenia[J]. China Journal of Health Psychology, 2008, 16(1):42-43. (in Chinese)
[[26]]   李俊花,黄文跃,刘 倩,等. 家庭干预对首发精神分裂症患者预后的影响[J]. 护理实践与研究,2008,5(13):45-46. LI Jun-hua, HUANG Wen-yue, LIU Qian, et al. Impact of family intervention on the prognosis of patients with sschizophrenia in first episode[J]. Nursing Practice and Research, 2008, 5(13):45-46. (in Chinese)
[[27]]   杨 萍,冉超群. 家庭治疗和护理干预对精神分裂症恢复期的疗效分析[J]. 现代医药卫生,2008,24(23):3538-3539. YANG Ping, RAN Chao-qun. Efficacy of family therapy and nursing intervention in recovery duration of patients with schizophrenia[J]. Journal of Modern Medicine Health, 2008, 24(23):3538-3539. (in Chinese)
[[28]]   刘 杰. 心理社会干预对精神分裂症康复影响的病例对照研究[J]. 中国民康医学(上半月),2008,20(23):2830-2831. LIU Jie. Rehabilitation of patients with schizophrenia psychosocial intervention effects on control study[J]. Medical Journal of Chinese People's Health, 2008, 20(23):2830-2831. (in Chinese)
[[29]]   范继美,孔 媛. 家庭护理干预对精神分裂症病人生活质量影响的评价[J]. 全科护理(下旬刊),2008,6(30):2758-2761. FAN Ji-mei, KONG Yuan. The effect of family nursing intervention for the quality of life of patients with schizophrenia[J]. Chinese General Nursing, 2008, 6(30):2758-2761. (in Chinese)
[[30]]   章秋明,黄腊根,朱春凤,等. 家庭干预对首发精神分裂症患者临床疗效对照分析[J]. 中华临床医学杂志,2008,9(7):21-23. ZHANG Qiu-ming, HUANG La-gen, ZHU Chun-feng, et al. Family intervention on controlled clinical efficacy in patients with first episode schizophrenia[J]. Chinese Journal of Clinical Practical Medicine, 2008, 9(7):21-23. (in Chinese)
[[31]]   郭红利,崔奎友,陶玉芬,等. 对精神分裂症患者社区家庭干预三年的随访研究[C]. 中国心理卫生协会残疾人心理卫生分会第七届学术交流会,成都:2008. GUO Hong-li, CUI Kui-you, TAO Yu-fen, et al. A follow-up study of three years of community family intervention in patients with schizophrenia[C]. China Mental Health Association, the Seventh Conference of The Disabled People's Mental Health, Chengdu:2008. (in Chinese)
[[32]]   李秀玲,卢世臣,刘庆海. 同步实施家庭干预对分裂症患者社会功能和生存质量的影响[J]. 国际护理学杂志,2008,27(5):459-462. LI Xiu-ling, LU Shi-chen, LIU Qing-hai. To investigate about society function,quality of life for the patients with schizophrenia by family interfere put in practice in-phase[J]. International Journal of Nursing, 2008, 27(5):459-462. (in Chinese)
[[33]]   郑婉玲,林 敏,林天安,等. 精神分裂症病人家庭健康教育研究[J]. 护理研究,2008,22(17):1536-1537. ZHENG Wan-ling, LIN Min, LIN Tian-an, et al. A study on family health education of schizophrenia patients[J]. Chinese Nursing Research, 2008, 22(17):1536-1537. (in Chinese)
[[34]]   国效峰,赵靖平,翟金国,等. 抗精神病药单用与结合心理社会干预对非慢性精神分裂症患者一年结局的影响[J]. 中华精神科杂志,2009,42(1):7-11. GUO Xiao-feng, ZHAO Jing-ping, ZHAI Jin-guo, et al. Antipsychotic alone venus combined with psychosocial intervention on one-year outcome in non-chronic schizophrenia[J]. Chinese Journal of Psychiatry, 2009, 42(1):7-11. (in Chinese)
[[35]]   谢红涛,陶梅芳,章 晖. 综合康复治疗对社区慢性精神分裂症患者认知功能影响的3年随访[J]. 上海精神医学,2009,21(2):74-77. XIE Hong-tao, TAO Mei-fang, ZHANG Hui. Three years follow-up study of efficacy of rehabilitation treatment on cognitive function in patients with chronic schizophrenia in the community[J]. Shanghai Archives of Psychiatry, 2009, 21(2):74-77. (in Chinese)
[[36]]   郭 珍,陆 峥,张 洁,等. 综合治疗对缓解期精神分裂症的作用[J]. 临床精神医学杂志,2009,19(6):367-369. GUO Zhen, LU Zheng, ZHANG Jie, et al. The influence of integrated treatment on patients with schizophrenia[J]. Journal of Clinical Psychiatry, 2009, 19(6):367-369. (in Chinese)
[[37]]   王延祜,唐济生,柴新生,等. 社区综合干预对精神分裂症患者社会康复效果的对照研究[J]. 精神医学杂志,2009,22(4):244-246. WANG Yan-gu, TANG Ji-sheng, CHAI Xin-sheng, et al. Comparative study of effects of comprehensive intervention in community on schizophrenic social rehabilitation[J]. Journal of Psychiatry, 2009, 22(4):244-246. (in Chinese)
[[38]]   刘力军,徐冬梅. 护理结合家庭干预对精神分裂症患者的生活质量的影响[J]. 中外健康文摘,2009,6(25):155-157. LIU Li-jun, XU Dong-mei. The impact on quality of life in patients with schizophrenia combined with family intervention nursing[J]. World Health Digest, 2009, 6(25):155-157. (in Chinese)
[[39]]   徐 娟,刘晓梅,邱大宏,等. 综合干预对改善首发精神分裂症患者临床症状及家庭、社会功能作用的3年随访对照研究[J]. 中国医师杂志,2009,11(12):1588-1591. XU Juan, LIU Xiao-mei, QIU Da-hong, et al. Randomized control study of effect of comprehensive intervention on the family and social functions in patients with schizophrenia[J]. Journal of Chinese Physician, 2009, 11(12):1588-1591. (in Chinese)
[[40]]   侯嘉文,林永娟,张美红. 家庭护理干预对提高精神分裂症患者生活质量的影响[J]. 国际医药卫生导报,2009,15(11):103-105. HOU Jia-wen, LIN Yong-juan, ZHANG Mei-hong. The impact of family nursing intervention to improve the quality of life of patients with schizophrenia[J]. International Medicine and Health Guidance News, 2009, 15(11):103-105. (in Chinese)
[[41]]   陶梅芳,章 晖,谢红涛. 对社区慢性精神分裂症患者个体综合康复治疗3年随访[J]. 中国民康医学,2009,21(17):2148-2149, 2151. TAO Mei-fang, ZHANG Hui, XIE Hong-tao. Three-year follow-up study of efficacy of rehabilitation treatment in chronic schizophrenics from community[J]. Medical Journal of Chinese People's Health, 2009, 21(17):2148-2149, 2151. (in Chinese)
[[42]]   潘友葵,苏保育,梁卫峰,等. 首发精神分裂症患者家属认知水平与患者康复效果的相关研究[J]. 中国民康医学, 2010, 22(23):2977-2978. PAN You-kui, SU Bao-yu, LIANG Wei-feng, et al. Relationship of the cognitive level of family dependents of patients with first onset schizophrenia and rehabilitation effect of the patients[J]. Medical Journal of Chinese People's Health, 2010, 22(23):2977-2978. (in Chinese)
[[43]]   赵 云,胡卫红,袁 前,等. 家庭干预对精神分裂症患者社区康复的影响[J]. 精神医学杂志,2010,23(6):436-438. ZHAO Yun, HU Wei-hong, YUAN Qian, et al. The effect of family intervention on schizophrenic patients in community[J]. Journal of Psychiatry, 2010, 23(6):436-438. (in Chinese)
[[44]]   张军勐,刘立芳,赵红梅,等. 精神分裂症社区康复疗效的对照研究[J]. 精神医学杂志,2010,23(2):123-125. ZHANG Jun-xun, LIU Li-fang, ZHAO Hong-mei, et al. Effects community-based rehabilitation on patients with schizophrenia[J]. Journal of Psychiatry, 2010, 23(2):123-125. (in Chinese)
[[45]]   张明兰,温从美,程兆萍,等. 社区综合心理干预对精神分裂症患者社会康复效果的影响[J]. 中国临床研究,2010,23(11):1062-1063. ZHANG Ming-lan, WEN Cong-mei, CHENG Zhao-ping, et al. Influence of community comprehensive psychological intervention on social rehabilitation of patients with schizophrenia[J]. Chinese Journal of Clinical Research,2010,23(11):1062-1063. (in Chinese)
[[46]]   李广田,田志林,李 达. 家庭心理干预对首发精神分裂症患者的影响[J]. 中国健康心理学杂志,2011,19(08):928-929. LI Guang-tian, TIAN Zhi-lin, LI Da. Family psychological intervention on patients with first episode schizophrenia[J]. China Journal of Health Psychology, 2011,19(08):928-929. (in Chinese)
[[47]]   马燕娟,王玉琦. 心理干预联合抗精神病药物治疗精神分裂症的临床研究[J]. 局解手术学杂志,2011,20(5):557-559. MA Yan-juan, WANG Yu-qi. Clinical study of psychological intervention combined with antipsychotics for schizophrenia[J]. Journal of Regional Anatomy and Operative Surgery, 2011, 20(5):557-559. (in Chinese)
[[48]]   朱建中,周兆新,李志佳. 系统家庭治疗对慢性精神分裂症患者认知功能的影响[J]. 中国健康心理学杂志,2011,19(10):1176-1178. ZHU Jian-zhong, ZHOU Zhao-xin, LI Zhi-jia. Effects on cognitive function in patients with chronic schizophrenia systemic family therapy[J]. China Journal of Health Psychology, 2011,19(10):1176-1178. (in Chinese)
[[49]]   岳长华. 综合家庭干预对农村精神分裂症患者康复的作用[J]. 中国老年保健医学,2011,09(1):27-28. YUE Chang-hua. Role of comprehensive rehabilitation of patients in rural family intervention for schizophrenia[J]. Chinese Journal of Geriatric Care, 2011, 09(1):27-28. (in Chinese)
[[50]]   方佳毅,黄承保. 心理干预与高情感表达家庭首发精神分裂症患者复发率相关性研究[J]. 航空航天医学杂志,2012,23(12):1443-1444. FANG Jia-yi, HUANG Cheng-bao. Study relativity between the recurrence rate of the first onset schizophrenic patients from the high expressed emotion family and psychological intervention[J]. Journal of Aerospace Medicine, 2012, 23(12):1443-1444. (in Chinese)
[[51]]   王 飞,李红丽. 家庭式康复治疗对慢性精神分裂症患者的近期疗效观察[J]. 中国药物滥用防治杂志,2012,18(5):269-272. WANG Fei, LI Hong-li. The observation of short-term efficacy of family rehabilitation of patients with chronic schizophrenia[J]. Chinese Journal of Drug Abuse Prevention and Treatment, 2012, 18(5):269-272. (in Chinese)
[[52]]   林 敏,郑婉玲,陈慧月,等. 家庭干预对精神分裂症病人预后及家属情感表达的影响[J]. 护理研究,2012,26(16):1526-1527. LIN Min, ZHENG Wan-ling, CHEN Hui-yue, et al. Influence of family intervention on prognosis of schizophrenia patients and emotion expression of family members[J]. Chinese Nursing Research,2012,26(16):1526-1527. (in Chinese)
[[53]]   陈 光,谢 焱,雷 黎,等. 精神分裂症综合干预的效果分析[J]. 广西医学,2012,34(9):1229-1231. CHEN Guang, XIE Yan, LEI Li, et al. Analysis of the effect of comprehensive intervention in schizophrenia[J]. Guangxi Medical Journal,2012,34(9):1229-1231. (in Chinese)
[[54]]   霍丽明,苏保育,陈汝兰. 家庭干预治疗对精神分裂症患者康复的影响[J]. 齐鲁护理杂志,2012,18(19):23-24. HUO Li-ming, SU Bao-yu, CHEN Ru-lan. Effect of family intervention on the rehabilitation of patients with schizophrenia[J]. Journal of Qilu Nursing,2012,18(19):23-24. (in Chinese)
[[55]]   王 志,刘晓伟,谈幼玉. 家庭干预在精神分裂症患者社会功能障碍康复中的效果分析[J]. 西南军医,2012,14(2):208-210. WANG Zhi, LIU Xiao-wei, TAN You-yu. Family Intervention effect on social dysfunction rehabilitation of schizophrenia[J]. Journal of Military Surgeon in Southwest China, 2012, 14(2):208-210. (in Chinese)
[[56]]   江学锋,张 晨,吴志国,等. 家庭干预对首发精神分裂症患者辅助治疗的随访研究[J]. 临床精神医学杂志,2012,22(1):1-4. JIANG Xue-feng, ZHANG Chen, WU Zhi-guo, et al. One-year follow up study of family intervention for first-episode schizophrenic patients[J]. Journal of Clinical Psychiatry,2012,22(1):1-4. (in Chinese)
[[57]]   张毓茂,郭玉花,黄 河,等. 综合性干预对复退军人精神分裂症36例患者院外康复的影响[J]. 中国民康医学,2013,25(7):19-21. ZHANG Yu-mao, GUO Yu-hua, HUANG He, et al. Influence of integrated intervention on out-hospital rehabilitation in 36 veterans with schizophrenia[J]. Medical Journal of Chinese People's Health, 2013, 25(7):19-21. (in Chinese)
[[58]]   赵红梅,李文秀,何 锐. 社区康复措施在康复期精神分裂症患者中的应用效果观察[J]. 海南医学,2013,24(6):836-838. ZHAO Hong-mei, LI Wen-xiu, HE Rui. Efficacy of community-based rehabilitation for patients with schizophrenia[J]. Hainan Medical Journal, 2013, 24(6):836-838. (in Chinese)
[[59]]   宋珀槿,裴双义,孙淑红. 家庭心理干预联合社会技能训练治疗康复期精神分裂症患者的疗效[J]. 中国老年学杂志,2013,33(20):5019-5020. SONG Bo-jin, PEI Shuang-yi, SUN Shu-hong. Family efficacy of psychological intervention combined with social skills training treatment and rehabilitation of patients with schizophrenia[J]. Chinese Journal of Gerontology,2013,33(20):5019-5020. (in Chinese)
[[60]]   李翠萍,黄 敏,付晓敏. 精神疾病患者康复期的家庭干预和社会支持对生活质量的影响[J]. 世界最新医学信息文摘(电子版),2013, 13(16):419-420. LI Cui-ping, HUANG Min, FU Xiao-min. Impact on the quality of life of family intervention and social support rehabilitation of patients with mental illness[J]. World Latest Medicine Information,2013, 13(16):419-420. (in Chinese)
[[61]]   李 祥,廖清香,肖文广. 家庭心理干预对首发精神分裂症患者服药依从性的3年随访对照研究[J]. 中国民康医学,2013,25(9):45-47. LI Xiang, LIAO Qing-xiang, XIAO Wen-guang. Family psychological intervention on patients with first-episode schizophrenia medication compliance control study of 3-year follow-up[J]. Medical Journal of Chinese People's Health,2013,25(9):45-47. (in Chinese)
[[62]]   郭玉花,张毓茂,黄 河,等. 综合性心理干预对复退军人精神分裂症患者社会功能的影响[J]. 临床心身疾病杂志,2013,19(5):420-421. GUO Yu-hua, ZHANG Yu-mao, HUANG He, et al. Influences of comprehensive psychological intervention on so-cial function of veteran patients with schizophrenia[J]. Journal of Clinical Psychosomatic Diseases,2013,19(5):420-421. (in Chinese)
[[63]]   翁睿贞,程晓雯,江学锋,等. 家庭干预对首发精神分裂症患者预后的影响[J]. 中华现代护理杂志,2013,19(21):2498-2501. WENG Rui-zhen, CHENG Xiao-wen, JIANG Xue-feng, et al. Effect of family intervention on the prognosis of first-episode patients with schizophrenia[J]. Chinese Journal of Modern Nursing,2013,19(21):2498-2501. (in Chinese)
[[64]]   李兰芳,李越霞,李文锋. 药物维持治疗联合家庭干预对首发精神分裂症患者的影响[J]. 护理实践与研究,2014,11(7):11-13. LI Lan-fang, LI Yue-xia, LI Wen-feng. The effect of drug maintenance therapy combined with family intervention for the first-episode schizophrenia in stable condition[J]. Nursing Practice and Research,2014,11(7):11-13. (in Chinese)
[[65]]   倪 花,蔡 军,李晨虎,等. 综合干预对社区精神分裂症患者社会功能的影响[J]. 临床精神医学杂志,2014,24(6):394-395. NI Hua, CAI Jun, LI Chen-hu, et al. Effects of comprehensive intervention on the social function in remission period patients with schizo-phrenia in community[J]. Journal of Clinical Psychiatry,2014,24(6):394-395. (in Chinese)
[[66]]   王晓枫,韦有芳. 综合心理干预对精神分裂症患者认知功能及生活质量的影响研究[J]. 四川精神卫生,2014,27(5):422-426. WANG Xiao-feng, WEI You-fang. Effects of psychological intervention on cognitive function and quality of life in patients with schizophrenia[J]. Sichuan Mental Health,2014,27(5):422-426. (in Chinese)
[[67]]   杨国文. 家庭护理干预对改善农村精神分裂症患者社会功能的作用[J]. 中国健康心理学杂志,2014,22(3):336-338. YANG Guo-wen. The effect of family nursing intervention on social function of rural communities schizophrenia[J]. China Journal of Health Psychology,2014,22(3):336-338. (in Chinese)
[[68]]   张文娟,刘培培,李健成. 家庭干预对首发精神分裂症患者康复的影响[J]. 中国健康心理学杂志,2014,22(11):1612-1613. ZHANG Wen-juan, LIU Pei-pei, LI Jian-cheng. The effect of family intervention on the rehabilitation of patients with first-episode schizophrenia[J]. China Journal of Health Psychology,2014,22(11):1612-1613. (in Chinese)
[[69]]   文 进,李幼平. Meta分析中效应尺度指标的选择[J]. 中国循证医学杂志,2007,7(8):608-613. WEN Jin, LI You-ping. The selection of a summary statistic for use in meta-analysis[J]. Chinese Journal of Evidence-Based Medicine, 2007, 7(8):608-613. (in Chinese)
[[70]]   周 涛,万 莹,徐 红,等. Meta分析文献的统计方法质量评价[J]. 中国社会医学杂志,2013,30(2):79-82. ZHOU Tao, WAN Ying, XU Hong, et al. Quality assessment of statistical methodology for the meta-analysis articles[J]. Chinese Journal of Social Medicine, 2013, 30(2):79-82. (in Chinese)
[[71]]   徐世侠,徐海琴,冯 博,等. 几种计算机软件在医学Meta分析中的应用[J]. 临床儿科杂志,2010,28(9):897-900. XU Shi-xia, XU Hai-qin, FENG Bo, et al. Several computer software used in medical meta analysis[J]. Journal of Clinical Pediatrics,2010,28(9):897-900. (in Chinese)
[[72]]   周旭毓,夏 旭. 医学信息定量综合的新方法——Meta分析[J]. 医学信息,2002,15(5):303-305. ZHOU Xu-yu, XIA Xu. A new method of medical information-meta-analysis[J]. Medical Information, 2002, 15(5):303-305. (in Chinese)
[[73]]   李 峥. 精神分裂症患者/家属(家庭)教育和干预的研究综述[J]. 中华护理杂志,2003,38(2):132-134. LI Zheng. Review of family education and intervention for patients with schizophrenia and their family[J]. Chinese Journal of Nursing,2003,38(2):132-134. (in Chinese)
[[74]]   张雪琴,沈静静,赵宝龙,等. 不同病程精神分裂症患者家庭干预效果比较[J]. 临床精神医学杂志,1999,9(04):214-216. ZHANG Xue-qin, SHEN Jing-jing, ZHAO Bao-long, et al. Chronicity of illness and effect of family intervention in schizophrenia[J]. Journal of Clinical Psychiatry,1999,9(04):214-216. (in Chinese)
[[75]]   施永斌,张 卫,赵宝龙,等. PANSS、SANS及SAPS量表一致性研究[J]. 上海精神医学,1999,11(01):23-25. SHI Yong-bin, ZHANG Wei, ZHAO Bao-long, et al. Consistency study of PANSS, SANS and SAPS scales.[J]. Shanghai Archives of Psychiatry,1999,11(01):23-25. (in Chinese)
[[76]]   何燕玲,张明园. 阳性和阴性综合征量表(PANSS)及其应用[J]. 临床精神医学杂志,1997,7(06):35-37. HE Yan-ling, ZHANG Ming-yuan. Positive and Negative Syndrome Scale (PANSS) and its applications[J]. Journal of Clinical Psychiatry, 1997, 7(06):35-37. (in Chinese)
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