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Journal of ZheJiang University(Medical Science)  2015, Vol. 44 Issue (6): 672-677    DOI: 10.3785/j.issn.1008-9292.2015.11.12
    
Research advances of anti-tumor immune response induced by pulse electric field ablation
CUI Guang-ying, DIAO Hong-yan
State Key Laboratory for Diagnosis and Treatment of Infectious Diseases, the First Affiliated Hospital, Zhejiang University School of Medicine, Collaborative Innovation Center for Diagnosis and Treatment of Infectious Diseases, Zhejiang University, Hangzhou 310003, China
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Abstract  

As a novel tumor therapy, pulse electric field has shown a clinical perspective. This paper reviews the characteristics of tumor ablation by microsecond pulse and nanosecond pulse electric field, and the research advances of anti-tumor immune response induced by pulse electric field ablation. Recent researches indicate that the pulse electric field not only leads to a complete ablation of local tumor, but also stimulates a protective immune response, thereby inhibiting tumor recurrence and metastasis. These unique advantages will show an extensive clinical application in the future. However, the mechanism of anti-tumor immune response and the development of related tumor vaccine need further studies.



Key wordsNeoplasms/therapy      Electroporation      Electrochemotherapy      Electromagnetic fields      Review     
Received: 30 June 2015      Published: 12 November 2015
CLC:  R730.5  
Cite this article:

CUI Guang-ying, DIAO Hong-yan. Research advances of anti-tumor immune response induced by pulse electric field ablation. Journal of ZheJiang University(Medical Science), 2015, 44(6): 672-677.

URL:

http://www.zjujournals.com/xueshu/med/10.3785/j.issn.1008-9292.2015.11.12     OR     http://www.zjujournals.com/xueshu/med/Y2015/V44/I6/672


脉冲电场肿瘤消融激发免疫反应的研究进展

脉冲电场作为一种新型的肿瘤治疗手段,显示出了良好的临床应用前景。本文综述了微秒脉冲电场和纳秒脉冲电场肿瘤消融的特点,主要阐述了脉冲电场肿瘤消融激发抗肿瘤免疫反应的研究进展,指出了脉冲电场不仅能够导致肿瘤局部彻底消融,还能激发机体保护性免疫反应,进而抑制肿瘤的复发和转移。这些独特优势对于肿瘤治疗有着广阔的临床应用前景。然而,脉冲电场消融所激发的保护性免疫反应的机制及肿瘤疫苗的研发是未来亟待解决的科学问题。


关键词: 肿瘤/治疗,  电穿孔,  电化学疗法,  电磁场,  综述 
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