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Journal of ZheJiang University(Medical Science)  2015, Vol. 44 Issue (5): 539-545    DOI: 10.3785/j.issn.1008-9292.2015.09.11
Antiepileptic effect of low frequency stimulation in kindling rats
LIU Yang1, WANG Yi2, XU Zheng-hao2,3, CHEN Zhong2
1. Department of Neurology, Zhejiang Hospital, Hangzhou 310013, China;
2. Department of Pharmacology, College of Pharmaceutical Science, Zhejiang University, Hangzhou 310058, China;
3. College of Basic Medical Science, Zhejiang Chinese Medical University, Hangzhou 310053, China
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Objective:To investigate the antiepileptic effects of various stimulation modes of low-frequency stimulation(LFS) on the kindling rats. Methods:Stimulating electrodes were implanted in the amygdala and current with constant intensity was applied to evoke kindling-induced seizures. The antiepileptic effect of LFS by open loop stimulation(before kindling), closed loop stimulation(immediately after kindling) and different forms of closed loop stimulation(whole stage after kindling and early stage after kindling) were investigated in amygdala kindled rats. Results:The closed loop LFS of whole stage after kindling can significantly inhibited seizure stages(P<0.01) and reduced afterdischarge duration(P<0.05). The closed loop LFS of early stage after kindling can significantly suppress the seizure stages, mainly in stages 0-3(P<0.05 or P<0.01). The open loop low-frequency stimulation did not inhibit the seizure stage during kindling acquisition(P>0.05). Conclusion:The antiepileptic effect of low frequency stimulation may have a mode-dependent effect. It may be helpful for the deep brain stimulation as a promising approach applied to clinical antiepileptic therapy in the future.

Key wordsElectric stimulation therapy      Epilepsy/therapy      Amygdala      Disease models, animal     
Received: 08 April 2015     
CLC:  R74  
Cite this article:

LIU Yang, WANG Yi, XU Zheng-hao, CHEN Zhong. Antiepileptic effect of low frequency stimulation in kindling rats. Journal of ZheJiang University(Medical Science), 2015, 44(5): 539-545.

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关键词: 电刺激疗法,  癫痫/治疗,  杏仁核,  疾病模型,动物 
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