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Journal of ZheJiang University(Medical Science)  2015, Vol. 44 Issue (3): 349-353    DOI: 10.3785/j.issn.1008-9292.2015.05.18
Malnutrition in early life and cardiovascular disease in adulthood
LAO Lin-jiang1, ZHANG Li-yan2, DU Li-zhong1
1. Department of Neonatology, the Children's Hospital, Zhejiang University School of Medicine, Hangzhou 310003, China;
2. Department of Neonatology, Fuzhou Children's Hospital, Fuzhou 350000, China
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Epidemiological and experimental studies have demonstrated that the risk of cardiovascular disease(CVD) in adulthood is influenced by the environment in early life. Intrauterine and early postnatal malnutrition and the following catch-up growth have a long-term effect on blood pressure and endothelial function in adulthood. Well-established prenatal or/and postnatal animal models are used to study the impact of different nutritional intervention on CVD in adulthood. This article reviews the early original cause of chronic CVD in adulthood with the hypothesis of DOHaD(the developmental origins of health and disease), and proposes possible preventions in early life on the basis of this theory.

Key wordsCardiovascular diseases/etiology      Cardiovascular diseases/epidemiology      Fetal development      Malnutrition      Models, animal      Review     
Received: 22 January 2015      Published: 25 May 2015
CLC:  R715  
Cite this article:

LAO Lin-jiang, ZHANG Li-yan, DU Li-zhong. Malnutrition in early life and cardiovascular disease in adulthood. Journal of ZheJiang University(Medical Science), 2015, 44(3): 349-353.

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关键词: 心血管疾病/病因学,  心血管疾病/流行病学,  胎儿发育,  营养不良,  模型,  动物,  综述 

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