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Journal of ZheJiang University(Medical Science)  2015, Vol. 44 Issue (3): 339-343    DOI: 10.3785/j.issn.1008-9292.2015.05.16
Research advances on prenatal maternal serum markers for screening adverse pregnancy outcomes
SHEN Qin-qin1, ZHANG Tan2
1. The Medical College of Ningbo University, Ningbo 315211, China;
2. Ningbo Women and Children's Hospital, Ningbo 315012, China
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The routine prenatal maternal serum testing is widely used for screening of birth defects, including Down syndrome, trisomy 18 syndrome and neural tube defects. The testing results are also associated with other adverse pregnant outcomes such as fetal surface structural abnormalities, gestational hypertension disease, intrahepatic cholestasis of pregnancy, premature rupture of membranes, abortion, stillbirth, intrauterine growth restriction and macrosomia; therefore the abnormal levels of serum markers might be used for predicting these adverse pregnant outcomes.

Key wordsPrenatal diagnosis      Biological markers      Pregnancy-associated plasma protein-A      Alpha-fetoproteins      Chorionic gonadotropin      Estriol      Inhibins      Pregnancy outcome     
Received: 06 January 2015      Published: 25 May 2015
CLC:  R715  
Cite this article:

SHEN Qin-qin, ZHANG Tan. Research advances on prenatal maternal serum markers for screening adverse pregnancy outcomes. Journal of ZheJiang University(Medical Science), 2015, 44(3): 339-343.

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关键词: 产前诊断,  生物学标记,  妊娠相关血浆蛋白A,  甲胎蛋白类,  人绒毛膜促性腺激素,  雌三醇,  抑制素类,  妊娠结局 

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