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Journal of ZheJiang University(Medical Science)  2014, Vol. 43 Issue (5): 607-    DOI: 10.3785/j.issn.1008-9292.2014.09.017
    
Roles of long noncoding RNA in lung cancer
LIU Yan-ru, ZHANG Rui-feng, YING Ke-jing
Department of Respiratory Medicine, Sir Run Run Shaw Hospital, Zhejiang University School of Medicine, Hangzhou 310016, China
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Abstract  

Long noncoding RNAs are a group of noncoding RNAs with a length more than 200 nucleotides. Recent studies have revealed that long noncoding RNAs play an important role in the development and progression of cancer. Lung cancer is the leading cause of cancer-related death all over the world. In this article, we review the roles of long noncoding RNAs in lung cancer to provide new insights into the diagnosis and treatment of the disease.



Key wordsRNA      Lung neoplasms      Gene expression regulation      Review     
Received: 04 April 2014      Published: 15 July 2014
CLC:  null  
Corresponding Authors: YING Ke-jing, E-mail: yingsrrsh@163.com   
Cite this article:

LIU Yan-ru, ZHANG Rui-feng, YING Ke-jing. Roles of long noncoding RNA in lung cancer. Journal of ZheJiang University(Medical Science), 2014, 43(5): 607-.

URL:

http://www.zjujournals.com/xueshu/med/10.3785/j.issn.1008-9292.2014.09.017     OR     http://www.zjujournals.com/xueshu/med/Y2014/V43/I5/607


长链非编码RNA与肺癌的关系研究进展

长链非编码RNA是一类长度大于200个核苷酸、因缺少有意义的开放阅读框而不具有编码蛋白功能的非编码RNA分子。近年来的研究表明,长链非编码RNA在肿瘤的发生、发展过程中起着重要的作用。本文就长链非编码RNA在肺癌中的异常表达、与肺癌发生和转移的关系、在肺癌患者早期诊断和判断预后中的意义等研究进展做一综述,为肺癌的早期诊断和治疗提供新的思路。


关键词: RNA,  肺肿瘤,  基因表达调控,  综述 
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