Please wait a minute...
Journal of ZheJiang University(Medical Science)  2014, Vol. 43 Issue (4): 406-412    DOI: 10.3785/j.issn.1008-9292.2014.07.003
    
Expressions of FOXC1 and MMP-7 in molecular subtypes of breast cancer and their association with clinicopathological characteristics
CAO Pei-long, WANG Kai, WANG Chun-bao, LI Xiao-feng, YANG Zhe, WANG Hong-yan
Department of Pathology, First Affiliated Hospital of Xian Jiaotong University School of Medicine, Xian 710061, China
Download:   PDF(1801KB)
Export: BibTeX | EndNote (RIS)      

Abstract  Objective: To investigate the expressions of FOXC1 and matrix metalloproteinase 7 (MMP-7) in different molecular subtypes of breast cancer and their association with clinicopathological characteristics of the disease. Methods: Based on immunohistochemical results of ER, PR, HER2, CK5/6, CK14 and EGFR, 105 breast cancer patients were classified as 4 subtypes: luminal, HER2 positive, basal-like subtype (BLs) and normal breast-like subtype (NBLs). The association of FOXC1 and MMP-7 expressions with clinicopathological parameters in different molecular subtypes was analyzed. Results: Out of 105 patients with breast cancer, the subtypes of luminal, HER2 positive, BLs and NBLs accounted for 52.4% (55/105), 16.2% (17/105), 17.1% (18/105) and 14.3% (15/105), respectively. Patients with luminal and/or NBLs subtypes had significantly higher 5-year survival rate than those with HER2 positive and/or BLs did (log-rank=22.161, P<0.01). The overall positive expression rate of FOXC1 was 26.7% (28/105) and the expression was higher in BLs patients than that in other subgroups (χ2=30.108, P<0.01). The expression of FOXC1 was correlated with histological grade, tumor size, distant metastasis and 5-year survival rate of breast cancer. The overall positive expression rate of MMP-7 was 67.6% (71/105)and the expression of MMP-7 was also higher in BLs patients than that in other molecular subtypes (χ2=11.328, P<0.05). The positive expression of MMP-7 was correlated with metastasis in ipsilateral axillary lymph nodes, distant metastasis and 5-year survival rate of the patients. FOXC1 was correlated with MMP-7 (r=0.325,P<0.01).Conclusion: Patients with luminal and/or NBLs breast cancer have more favorable prognosis than those with HER2 positive and/or BLs subtypes. The expressions of FOXC1 and MMP-7 are closely correlated with the clinicopathological features of breast cancer patients.

Key wordsBreast neoplasms/pathology丨Breast neoplasms/diagnosis丨FOXC1;Matrix metalloproteinase 7/metabolism丨Transcription factors/metabolism丨Gene expression      Prognosi丨Immunohistochemistry      Follow-up study      
Received: 08 March 2014     
Corresponding Authors: WANG Hong-yan, E-mail: whycc0320@126.com   
Cite this article:

CAO Pei-long,et al. Expressions of FOXC1 and MMP-7 in molecular subtypes of breast cancer and their association with clinicopathological characteristics . Journal of ZheJiang University(Medical Science), 2014, 43(4): 406-412.

URL:

http://www.zjujournals.com/xueshu/med/10.3785/j.issn.1008-9292.2014.07.003     OR     http://www.zjujournals.com/xueshu/med/Y2014/V43/I4/406


转录因子FOXC1、基质金属蛋白酶7在不同乳腺癌分子亚型中的表达及与临床病理的相关性分析

目的: 观察转录因子FOXC1、基质金属蛋白酶7(MMP-7)在乳腺癌各分子亚型中的表达情况,探讨FOXC1、MMP-7对乳腺癌分子亚型的诊断及预后价值。方法:105例乳腺癌患者根据免疫组织化学检测ER、PR、HER2、CK5/6、CK14、EGFR结果分为四型:腔型、HER2阳性型、基底细胞样型(BLs型)及正常乳腺样型(NBLs型)。观察各乳腺癌分子亚型的临床特征及与FOXC1、MMP-7的关系。结果:在105例乳腺癌患者中腔型、HER2阳性型、BLs型和NBLs型乳腺癌所占比例分别为52.4%(55/105)、16.2%(17/105)、17.1%(18/105)、14.3%(15/105)。腔型和(或)NBLs型乳腺癌患者5年生存率明显高于HER2阳性型和(或)BLs型患者(log-rank值为22.161,P<0.01)。FOXC1阳性表达共28例,阳性表达率为26.7%(28/105),FOXC1表达与肿瘤组织学分级、肿瘤大小、远处转移及患者5年生存率有关,而且FOXC1在BLs型乳腺癌中阳性表达率显著高于其他分子亚型乳腺癌(χ2=30.108,P<0.01)。MMP-7阳性表达共71例,阳性表达率为67.6%(71/105),MMP-7与患者同侧腋窝淋巴结转移、远处转移及患者5年生存率有关。MMP-7在BLs型乳腺癌中阳性表达率也高于其他分子亚型乳腺癌(χ2=11.328,P<0.05)。FOXC1与MMP-7的表达呈正相关(r=0.325, P<0.01)。结论:腔型和NBLs型乳腺癌患者预后较好,HER2阳性型和BLs型乳腺癌预后较差。FOXC1可能作为BLs型乳腺癌的特异性潜在分子标志物和潜在治疗靶点。MMP-7可能作为判断乳腺癌侵袭性、恶性程度及评估预后的有用指标。FOXC1与MMP-7在分子机制上可能存在一定的联系。
No related articles found!