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浙江大学学报（医学版）
Journal of ZheJiang University(Medical Science)  2014, Vol. 43 Issue (4): 413-419    DOI: 10.3785/j.issn.1008-9292.2014.06.001
    
Correlation of PBX2/ELF2 expression with prognosis of non-small cell lung cancer
JIN Shu-qing1， PU Yu-fei1， QIU Ying2， Katsuyuki AOZASA3， Eiichi MORII3
1.Department of Medicine， Tongji University， Shanghai 200092，China; 2.Department of Pathology， Tsinghua University， Beijing 100084，China; 3. Department of Pathology， Graduate School of Medicine， Osaka University 2-2 Yamadaoka， Osaka 565-0871， Japan）
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Abstract  Objective： To investigate the relationship between pre B cell leukemia transcription factor 2 （PBX2）/Ets domain transcription factor 2 （ELF2 ） expression with prognosis of non-small cell lung cancer （NSCLC）. Methods： Expressions of ELF2 and PBX2 were examined in 206 patients of NSCLC by immunohistochemistry. The correlation of PBX2/ELF2 expression with valosin-containing protein （VCP） expression and clinicopathologic factors of NSCLC patients was analyzed. Chi-square test， Fishers exact test and Coxs regression were used for statistical analysis. Results： The level of PBX2/ELF2 expression was associated with VCP expression （P=0.0126）. Univariate analysis showed that 5-y disease free survival and overall survival （OS） of NSCLC were correlated with expression of PBX2， PBX2/ELF2 and VCP， tumor size， histological differentiation， visceral pleural invasion， N and T in pTNM grades， and clinical stages （P<0.05）. The 5-y OS was also related to vascular invasion （P=0.0322）. Multivariate analysis revealed that the expression level of PBX2/ELF2 and histological differentiation were independent predictors for NSCLC. Conclusion： The level of PBX2/ELF2 expression is related to VCP expression， indicating that PBX2/ELF2-VCP pathway may be associated with the prognosis of NSCLC patients．

Received: 16 August 2013     
Corresponding Authors: QIU Ying，E-mail: yingqiu@biomed.tsinghua.edu.cn   
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JIN Shu-qing，et al. Correlation of PBX2/ELF2 expression with prognosis of non-small cell lung cancer. Journal of ZheJiang University(Medical Science), 2014, 43(4): 413-419.

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http://www.zjujournals.com/xueshu/med/10.3785/j.issn.1008-9292.2014.06.001     OR     http://www.zjujournals.com/xueshu/med/Y2014/V43/I4/413


组织PBX2/ELF2表达水平与非小细胞肺癌患者预后相关性分析

目的：检测前B细胞白血病转录因子-2（PBX2）/ Ets家族转录因子-2 （ELF2）的表达，探讨PBX2/ELF2表达与非小细胞肺癌（NSCLC）预后的关系。 方法：对206例NSCLC手术切除标本进行ELF2、PBX2的免疫组织化学染色，采用χ2检验、Fisher确切检验、Coxs回归等统计学方法分析比较PBX2/ELF2共表达与缬酪肽包含蛋白（VCP）表达、肿瘤浸润、转移、患者预后等的关系。 结果：PBX2/ELF2表达与VCP表达高度相关（P=0.0126）。单变量分析PBX2表达、PBX2/ELF2表达、VCP表达、肿瘤直径、组织分化程度、胸膜转移、浸润深度、区域淋巴结转移、临床分期与NSCLC患者5年无病生存率、总体生存率相关（均P<0.05），5年总体生存率与血管侵袭也相关（P=0.0322）；多变量分析显示PBX2/ELF2表达、组织分化程度是NSCLC预后的独立相关因子。 结论：PBX2/ELF2表达与VCP表达呈正相关，PBX2/ELF2-VCP通路与NSCLC患者预后相关。

关键词： PBX2丨ELF2丨非小细胞肺/病理学丨转录因子丨基因,  同源盒丨基因表达丨预后丨免疫组织化学  
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