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Journal of ZheJiang University(Medical Science)  2014, Vol. 43 Issue (4): 413-419    DOI: 10.3785/j.issn.1008-9292.2014.06.001
Correlation of PBX2/ELF2 expression with prognosis of non-small cell lung cancer
JIN Shu-qing1, PU Yu-fei1, QIU Ying2, Katsuyuki AOZASA3, Eiichi MORII3
1.Department of Medicine, Tongji University, Shanghai 200092,China; 2.Department of Pathology, Tsinghua University, Beijing 100084,China; 3. Department of Pathology, Graduate School of Medicine, Osaka University 2-2 Yamadaoka, Osaka 565-0871, Japan)
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Abstract  Objective: To investigate the relationship between pre B cell leukemia transcription factor 2 (PBX2)/Ets domain transcription factor 2 (ELF2 ) expression with prognosis of non-small cell lung cancer (NSCLC). Methods: Expressions of ELF2 and PBX2 were examined in 206 patients of NSCLC by immunohistochemistry. The correlation of PBX2/ELF2 expression with valosin-containing protein (VCP) expression and clinicopathologic factors of NSCLC patients was analyzed. Chi-square test, Fishers exact test and Coxs regression were used for statistical analysis. Results: The level of PBX2/ELF2 expression was associated with VCP expression (P=0.0126). Univariate analysis showed that 5-y disease free survival and overall survival (OS) of NSCLC were correlated with expression of PBX2, PBX2/ELF2 and VCP, tumor size, histological differentiation, visceral pleural invasion, N and T in pTNM grades, and clinical stages (P<0.05). The 5-y OS was also related to vascular invasion (P=0.0322). Multivariate analysis revealed that the expression level of PBX2/ELF2 and histological differentiation were independent predictors for NSCLC. Conclusion: The level of PBX2/ELF2 expression is related to VCP expression, indicating that PBX2/ELF2-VCP pathway may be associated with the prognosis of NSCLC patients.

Received: 16 August 2013     
Corresponding Authors: QIU Ying,E-mail:   
Cite this article:

JIN Shu-qing,et al. Correlation of PBX2/ELF2 expression with prognosis of non-small cell lung cancer. Journal of ZheJiang University(Medical Science), 2014, 43(4): 413-419.

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目的:检测前B细胞白血病转录因子-2(PBX2)/ Ets家族转录因子-2 (ELF2)的表达,探讨PBX2/ELF2表达与非小细胞肺癌(NSCLC)预后的关系。 方法:对206例NSCLC手术切除标本进行ELF2、PBX2的免疫组织化学染色,采用χ2检验、Fisher确切检验、Coxs回归等统计学方法分析比较PBX2/ELF2共表达与缬酪肽包含蛋白(VCP)表达、肿瘤浸润、转移、患者预后等的关系。 结果:PBX2/ELF2表达与VCP表达高度相关(P=0.0126)。单变量分析PBX2表达、PBX2/ELF2表达、VCP表达、肿瘤直径、组织分化程度、胸膜转移、浸润深度、区域淋巴结转移、临床分期与NSCLC患者5年无病生存率、总体生存率相关(均P<0.05),5年总体生存率与血管侵袭也相关(P=0.0322);多变量分析显示PBX2/ELF2表达、组织分化程度是NSCLC预后的独立相关因子。 结论:PBX2/ELF2表达与VCP表达呈正相关,PBX2/ELF2-VCP通路与NSCLC患者预后相关。

关键词: PBX2丨ELF2丨非小细胞肺/病理学丨转录因子丨基因,  同源盒丨基因表达丨预后丨免疫组织化学  
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