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Journal of ZheJiang University(Medical Science)  2014, Vol. 43 Issue (3): 359-365    DOI: 10.3785/j.issn.10089292.2014.04.006
    
The role of primary cilium in signal transduction and its mechanism
SHI Wen-gui,MA Xiao-ni,CHEN Ke-ming
Institute of Orthopedics, PLA Lanzhou Commond General Hospital, Lanzhou 730050, China
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Abstract  

The primary cilium is a solitary and special organelle that emanates from the cell surface of most mammalian cells,which is anchored to the cell by mother centriole during the interphase and G0 of cell cycle. Recent studies have revealed that the primary cilium is a sensory organelle to receive extracellular signals and plays a key role in the signal transduction and pathogenesis of diseases. This review presents the structure and the forming process of the primary cilium during cell cycle. The signal transductions associated with primary cilium, including plateletderived growth factor receptor αα, hedgehog, Wnt are discussed and the relevant researches in the future are proposed.



Key wordsCilia      Signal processing, computerassisted      Structureactivity relationship      Organelles      Staining and labeling      Genes      Microscopy/instrumentation      Signal transduction;       Review     
Received: 03 October 2013     
Corresponding Authors: CHEN Keming; Email: chkeming@aliyun.com.cn    
Cite this article:

SHI Wen-gui,MA Xiao-ni,CHEN Ke-ming. The role of primary cilium in signal transduction and its mechanism. Journal of ZheJiang University(Medical Science), 2014, 43(3): 359-365.

URL:

http://www.zjujournals.com/xueshu/med/10.3785/j.issn.10089292.2014.04.006     OR     http://www.zjujournals.com/xueshu/med/Y2014/V43/I3/359


初级纤毛在细胞信号转导中的作用与机制

初级纤毛是一种存在于大多数哺乳动物细胞表面的特殊细胞器,在细胞分裂间期和G0期通过中心粒锚定于细胞表面。 近年来的研究表明,初级纤毛作为一种位于细胞表面的信号感受器官,在信号转导与疾病发生中起到重要作用,已日益成为国际性研究热点。本文综述了初级纤毛的微结构及其伴随细胞周期重建与解体的过程,着重讨论了初级纤毛在PDGFRαα(platelet derived growth factor receptor αα)、Hg(Hedgehog)、Wnt信号通路中的作用以及相关研究进展,展望了初级纤毛今后的研究趋势。


关键词: 纤毛;信号处理, 计算机辅助;构效关系;细胞器;染色与标记;基因;显微镜检查/仪器和设备;信号传导,  综述 
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