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| Determination of enantiomeric impurity in levocetirizine tablets by capillary electrophoresis |
| WANG Shi-zhuo, ZHAO Yun-feng, SUN Jia-yi, GUO Xing-jie |
| School of Pharmacy, Shenyang Pharmaceutical University, Shenyang 110016, China |
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Abstract Objective： To determine enantiomeric impurity in levocetirizine tablets by using capillary electrophoresis.Methods： The effects of pH and the concentrations of sulfated-β-cyclodextrin (S-β-CD) and buffer salt on chiral resolution were examined with S-β-CD as chiral selector. Results： A good enantioseparation of cetirizine was achieved with 30 mmol/L NaH2PO4 buffer solution (pH 7.0) containing 20 g/L of S-β-CD.Conclusion： The method developed in the study is sensitive and reliable for determination of enantiomeric impurity in levocetirizine tablets.
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Received: 29 October 2013
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Corresponding Authors:
GUO Xing-jie, E-mail: syykdx410@163.com
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毛细管电泳法检查盐酸左西替利嗪片中右旋异构体杂质
目的：建立毛细管电泳法检查盐酸左西替利嗪片中右旋异构体杂质。方法：用磺酸化-β-环糊精（S-β-CD）作为手性选择剂，考察了S-β-CD浓度、pH值和缓冲盐浓度对分离的影响。结果：在30 mmol/L磷酸盐运行缓冲液(含20 g/L S-β-CD，pH 7.0)中，西替利嗪对映体在分离电压为15 kV的条件下得到良好分离，并满足对盐酸左西替利嗪片检查右旋异构体杂质所需要的条件。结论：本实验建立的方法灵敏、可靠，可用于左旋西替利嗪中右旋异构体杂质的检查。
关键词：
西替利嗪/分析,
西替利嗪/类似物和衍生物,
电泳,
毛细管/方法,
&beta,
环糊精类/化学,
立体异构现象
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