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Journal of ZheJiang University(Medical Science)  2013, Vol. 42 Issue (6): 700-704    DOI: 10.3785/j.issn.1008-9292.2013.06.019
    
Research advance on bacteriophage therapy in bacterial infection
PEI Jingliang1,FU Yurong2
1.Affiliated Hospital of Weifang Medical University,Key Laboratory of Clinical Diagnosis in Universities of Shandong,Weifang 261031; 2.Department of Microbiology,Weifang Medical University,Weifang 261053;
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Abstract  

Bacteriophage is a bacterium dependent virus.It has unique advantages in the treatment of bacterial infection,especially infection caused by drug-resistant bacteria.Its metabolic kinetics and route of administration are the current research focus.Bacteriophage lytic enzyme,as a new therapeutic method,has more advantages than active bacteriophage.This review is focused on the recent progress in bacteriophage research,including the mechanism of bacteria lysis,the route of administration,the application of genetic engineering,etc.



Key wordsBacteriophages      Lytic enzymes      Route of administration      Bacterial infection/therapy     
Received: 03 September 2012      Published: 25 November 2013
Cite this article:

PEI Jingliang,FU Yurong. Research advance on bacteriophage therapy in bacterial infection. Journal of ZheJiang University(Medical Science), 2013, 42(6): 700-704.

URL:

https://www.zjujournals.com/med/10.3785/j.issn.1008-9292.2013.06.019     OR     https://www.zjujournals.com/med/Y2013/V42/I6/700


噬菌体治疗细菌感染的研究进展

噬菌体是一种细菌依赖性病毒,在治疗细菌特别是耐药性细菌感染方面,与传统的抗生素比较具有独特的优势,其代谢动力学及给药途径是目前的研究热点。噬菌体裂解酶作为一种新的治疗手段,具有比活性噬菌体制剂更多的优点。文中就噬菌体在细菌感染治疗方面的作用机理、给药途径和基因工程的应用,及噬菌体裂解素的研究进展进行综述,对噬菌体治疗细菌感染提出展望。


关键词: 细菌噬菌体,  裂解酶,  给药途径,  细菌感染/治疗 
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