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浙江大学学报（医学版）
Journal of ZheJiang University(Medical Science)  2013, Vol. 42 Issue (6): 693-699    DOI: 10.3785/j.issn.1008-9292.2013.06.018
    
Progress on neuroprotective effects of erythropoietin
LIU Xin， WU Haiqin
Department of Neurology，The Second Affiliated Hospital，Medical College of Xi′an Jiaotong University，Xi′an 710004，China
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Abstract  

The function of erythropoietin (EPO) is recognized as a stimulator for proliferation of red blood cell (RBC)，however，recent studies have showed that EPO and EPO-R are widely distributed in nervous system，which indicates that it may also have important functions in neurosystem.Studies proved its neuroprotective effects，especially in ischemic-hypoxic nerve tissues.These effects are mainly activated through several signal transduction pathway downstream and multiple mechanisms are involved.As a neuroprotective factor，EPO has been investigated in the clinical studies，which may lead to the clinical application in the future.

Key words： Erythropoietin/physiology      Central nervous system/physiology      Signal transduction      Erythropoietin(EPO)      Neuroprotective      Mechanism     
Received: 09 October 2012      Published: 25 November 2013
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刘欣（1988-），女，硕士研究生，从事神经系统衰老研究.
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Cite this article:

LIU Xin， WU Haiqin. Progress on neuroprotective effects of erythropoietin. Journal of ZheJiang University(Medical Science), 2013, 42(6): 693-699.

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https://www.zjujournals.com/med/10.3785/j.issn.1008-9292.2013.06.018     OR     https://www.zjujournals.com/med/Y2013/V42/I6/693


促红细胞生成素的神经保护作用

促红细胞生成素（erthropoietin，EPO）主要以调节红细胞生成而被人们广泛认识，而最近研究发现EPO及其受体在神经系统中广泛分布，提示其可能对神经系统有重要作用。许多研究证明，EPO对神经系统疾病有重要的保护作用，这种作用在低氧缺血的条件下表现特别明显。EPO主要通过激活一系列信号转导通路及多种可能的机制发挥神经保护作用。EPO作为一种神经保护剂已经应用于临床研究，但最终应用于临床治疗还需要进行大量的研究。


关键词： 红细胞生成素/生理学,  中枢神经系统/生理学,  信号传导,  促红细胞生成素,  神经保护,  作用机制 
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