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Journal of ZheJiang University(Medical Science)  2013, Vol. 42 Issue (6): 620-624    DOI: 10.3785/j.issn.1008-9292.2013.06.005
    
Effects of chrysalis oil on learning,memory and oxidative stress in D-galactose-induced ageing model of mice
CHEN Weiping,YANG Qiongjie,WEI Xing
Zhejiang University City College,School of Medicine,Hangzhou 310015
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Abstract  

Objective: To investigate the effects of chrysalis oil on learning,memory and oxidative stress in D-galactose-induced ageing model of mice.
Methods: Mice were injected intraperitoneally with D-galactose daily and received chrysalis oil intragastrically simultaneously for 30 d.Then mice underwent space navigation test and spatial probe test,superoxide dismutase (SOD),glutathione peroxidase (GSH-PX) activity and malondialdehyde (MDA) contents in mouse brain were measured.
Results: Compared to model group,escape latency in mice treated with 6 ml/kg·d chrysalis oil was significantly shorter (P<0.05),crossing times in 12 ml/kg·d group and 6 ml/kg·d group treated with chrysalis oil were significantly increased (P <0.05).Chrysalis oil treatment (12ml/kg·d) significantly increased SOD and GSH-PX activity and reduced MDA contents in brain of D-galactose-induced aging mice.
Conclusion: Chrysalis oil can improve the ability of learning and memory in D-galactose-induced aging mice,and inhibit peroxidation in brain tissue.



Key wordsPupa      Bombyx      Galactose/pharmacology      Oxidative stress      Memory      Randomized controlled trial      Chrysalis oil      D-galactose      Learning and memory      Antioxidation     
Received: 20 August 2013      Published: 25 November 2013
Cite this article:

CHEN Weiping,YANG Qiongjie,WEI Xing. Effects of chrysalis oil on learning,memory and oxidative stress in D-galactose-induced ageing model of mice. Journal of ZheJiang University(Medical Science), 2013, 42(6): 620-624.

URL:

https://www.zjujournals.com/med/10.3785/j.issn.1008-9292.2013.06.005     OR     https://www.zjujournals.com/med/Y2013/V42/I6/620


蚕蛹油对D-半乳糖模型小鼠学习记忆及氧化应激的影响

目的:观察蚕蛹油对D-半乳糖致衰老小鼠学习记忆能力及机体抗氧化能力的影响,为蚕蛹油的临床应用积累资料。
方法:连续给小鼠腹腔注射D-半乳糖30 天,同时用蚕蛹油灌胃给药,给药结束后用Morris水迷宫进行4天的定位航行试验,测定逃避潜伏期;第5天进行空间搜索试验,测定其穿越平台次数;并比较了各组小鼠组织中超氧化物歧化酶(SOD)、谷胱甘肽过氧化物酶(GSH-PX)活性和丙二醛(MDA)含量。
结果:与模型组比较,蚕蛹油6 ml/kg·d组逃避潜伏期明显短于模型组(P<0.05);蚕蛹油6 ml/kg·d组与12 ml/kg·d组穿越平台次数明显多于模型组(P<0.05);蚕蛹油12 ml/kg·d组能显著提高D-半乳糖所致衰老小鼠脑组织SOD、GSH-PX活性,降低脂质过氧化产物MDA的含量。
结论:蚕蛹油能改善D-半乳糖致衰老小鼠的学习记忆能力,有抑制其脑组织脂质过氧化的作用。


关键词: 蛹,  蚕属,  半乳糖/药理学,  氧化性应激,  记忆,  随机对照试验,  蚕蛹油,  D-半乳糖,  学习记忆,  抗氧化 
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