|
|
|
| Progress in TcpC research |
| PAN Jian-Ping1, XIN Xiao-Li2 |
| 1.Zhejiang University City College School of Medicine，Hangzhou 310015; 2.Department of Basic Medicine，Zhejiang University School of Medicine，Hangzhou 310058 |
|
|
|
Abstract TcpC is a homolog of the Toll/interleukin-1 receptor (TIR) domain and is secreted by uropathogenic E. coli strain CFT073. TcpC can bind to MyD88，hereby exerting inhibitory effects on macrophages. TcpC represents an important virulence factor that promotes bacterial survival and pathogenicity. TcpC plays a critical role in urinary tract infection，particularly in the pathogenesis of pyelonephritis. In this review，the progress and prospects in TcpC research are discussed.
|
|
Received: 31 May 2013
Published: 25 September 2013
|
|
|
TcpC研究现状与展望
TcpC是尿路致病性大肠埃希菌CFT073菌株分泌的一种Toll/interleukin-1 receptor（TIR）结构域类似物。它通过与髓样分化因子88结合，抑制Toll样受体信号途径介导的巨噬细胞活化和杀菌功能、从而逃逸机体免疫效应，利于大肠埃希菌在宿主体内的生存和繁殖，是大肠埃希菌重要的毒力因子，在肾盂肾炎等尿路感染发生中起重要作用。同时体内诱导β干扰素的TIR结构域衔接蛋白、干扰素调节因子3、以及白介素1β对TcpC发挥作用具有显著影响。本文介绍TcpC研究的现状和发展趋势。
关键词：
泌尿道感染,
肠致病性大肠杆菌,
Toll样受体,
肾盂肾炎
|
|
| [[1]] |
MEDZHITOV R，JANEWAY C，Jr.Innate immune recognition: mechanisms and pathways [J].Immunol Rev，2000，173:89-97.
|
|
|
| [[2]] |
CIRL C，WIESER A，YADAV M，et al.Subversion of Toll-like receptor signaling by a unique family of bacterial Toll/interleukin-1 receptor domain-containing proteins [J].Nat Med，2008，14 (4):399- 406.
|
|
|
| [[3]] |
SNYDER G A，CIRL C，JIANG J，et al.Molecular mechanisms for the subversion of MyD88 signaling by TcpC from virulent uropathogenic Escherichia coli [J].Proc Natl Acad Sci U S A，2013，110(17):6985-6990.
|
|
|
| [[4]] |
MAHJOUB-MESSAI F，BIDET P，CARO V，et al.Escherichia coli isolates causing bacteremia via gut translocation and urinary tract infection in young infants exhibit different virulence genotypes [J].J Infect Dis，2011，203(12):1844-1849.
|
|
|
| [[5]] |
STARCIC ERJAVEC M，JESENKO B，PETKOVSEK Z，et al.Prevalence and associations of tcpC，a gene encoding a Toll/interleukin-1 receptor domain-containing protein，among Escherichia coli urinary tract infection，skin and soft tissue infection，and commensal isolates [J].J Clin Microbiol，2010，48(3):966-968.
|
|
|
| [[6]] |
SCHUBERT S，NORENBERG D，CLERMONT O，et al.Prevalence and phylogenetic history of the TcpC virulence determinant in Escherichia coli [J].Int J Med Microbiol，2010，300(7):429- 434.
|
|
|
| [[7]] |
LI C，ZIENKIEWICZ J，HAWIGER J.Interactive sites in the MyD88 Toll/interleukin (IL) 1 receptor domain responsible for coupling to the IL1beta signaling pathway [J].J Biol Chem，2005，280(28):26152-26159.
|
|
|
| [[8]] |
AKIRA S，TAKEDA K.Toll-like receptor signalling [J].Nat Rev Immunol，2004，4(7):499-511.
|
|
|
| [[9]] |
IWASAKI A，MEDZHITOV R.Toll-like receptor control of the adaptive immune responses [J].Nat Immunol，2004，5(10):987-995.
|
|
|
| [[10]] |
KAWAI T，AKIRA S.TLR signaling [J].Cell Death Differ，2006，13(5):816-825.
|
|
|
| [[11]] |
MEDZHITOV R.Toll-like receptors and innate immunity [J].Nat Rev Immunol，2001，1(2):135-145.
|
|
|
| [[12]] |
AKIRA S，UEMATSU S，TAKEUCHI O.Pathogen recognition and innate immunity [J].Cell，2006，124 (4):783-801.
|
|
|
| [[13]] |
FEHLINGS M，DROBBE L，MOOS V，et al.Comparative analysis of the interaction of Helicobacter pylori with human dendritic cells，macrophages，and monocytes [J].Infect Immun，2012，80(8):2724-2734.
|
|
|
| [[14]] |
YADAV M，ZHANG J，FISCHER H，et al.Inhibition of TIR domain signaling by TcpC: MyD88-dependent and independent effects on Escherichia coli virulence [J].PLoS Pathog，2010，6(9):e1001120.
|
|
|
| [[15]] |
OSHIUMI H，MATSUMOTO M，FUNAMI K，et al.TICAM-1，an adaptor molecule that participates in Toll-like receptor 3-mediated interferon-beta induction [J].Nat Immunol，2003，4(2):161-167.
|
|
|
| [[16]] |
AKIRA S.TLR signaling [J].Curr Top Microbiol Immunol，2006，311:1-16.
|
|
|
| [[17]] |
TANIGUCHI T，OGASAWARA K，TAKAOKA A，et al.IRF family of transcription factors as regulators of host defense [J].Annu Rev Immunol，2001，19:623-655.
|
|
|
| [[18]] |
HONDA K，TANIGUCHI T.IRFs: master regulators of signalling by Toll-like receptors and cytosolic pattern-recognition receptors [J].Nat Rev Immunol，2006，6(9):644-658.
|
|
|
|
Viewed |
|
|
|
Full text
|
|
|
|
|
Abstract
|
|
|
|
|
Cited |
|
|
|
|
| |
Shared |
|
|
|
|
| |
Discussed |
|
|
|
|
