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Journal of ZheJiang University(Medical Science)  2013, Vol. 42 Issue (2): 224-231    DOI: 10.3785/j.issn.1008-9292.2013.02.015
    
Gonadotropin-inhibitory hormone in regulation of reproduction and behavior in mammalians
MENG Fan-Sen, CHEN Xue-Qun, DU Ji-Zeng
Department of Basic Medical Sciences,Zhejiang University School of Medicine,Hangzhou 310058,China
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Abstract  

RF-amide related peptide(RFRP) is the orthologue of gonadtropin-inhibitory hormone(GnIH) in mammals.The bodies of RFRP cell are located in the dorsomedial nucleus of the hypothalamus(DMH) and the fibers project to preoptic area(POA) and median eminence of the hypothalamus.Its receptor mainly distributes in hypothalamus.RFRP fibers project to GnRH cells to regulate mammalian reproduction axis.This paper reviews the progress of current researches on RFRP in regulation of animal behaviors,including reproduction,food intake,anxiety and stress response.



Key wordsGonadotropin-inhibitory hormone      Gonadotropin-releasing hormone      Reproduction      Stress      Food intake     
Received: 08 February 2012      Published: 25 March 2013
CLC:  Q 492  
Cite this article:

MENG Fan-Sen, CHEN Xue-Qun, DU Ji-Zeng. Gonadotropin-inhibitory hormone in regulation of reproduction and behavior in mammalians. Journal of ZheJiang University(Medical Science), 2013, 42(2): 224-231.

URL:

http://www.zjujournals.com/med/10.3785/j.issn.1008-9292.2013.02.015     OR     http://www.zjujournals.com/med/Y2013/V42/I2/224


哺乳动物促性腺激素抑制激素的生殖内分泌调节与行为作用

哺乳动物中促性腺激素抑制激素(gonadotropin-inhibitory hormone,GnIH)同源物(RF-amide related peptide,RFRP)的神经元胞体主要存在于下丘脑背内侧核(dorsomedial hypothalamic nucleus,DMH),其神经纤维主要投射到视前区(preoptic area,POA)和下丘脑正中隆起,其受体主要分布在下丘脑。RFRP神经元投射到促性腺激素释放激素(gonadotropin-releasing hormone,GnRH)神经元上;最终,RFRP和GnRH共同完成哺乳动物生殖轴功能调节。


关键词: 促性腺激素抑制激素,  促性腺激素释放激素,  生殖,  应激,  摄食 


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