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Journal of ZheJiang University(Medical Science)  2013, Vol. 42 Issue (2): 217-223    DOI: 10.3785/j.issn.1008-9292.2013.02.014
p53-independent signaling pathway in DNA damage-induced cell apoptosis
ZHANG Xiao-Yun1, JIANG Ying2, YANG Jun1,3
1.Zhejiang University School of Public Health,Hangzhou 310058,China;2.Center Testing International Corporation,Guangdong 518101,China;3.Department of Toxicology,Hangzhou Normal University School of Public Health,Hangzhou 310036,China;
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p53 is considered as the “master regulator” in DNA damage-induced cell apoptosis.However,p53 is the most frequently mutated gene in human cancers (more than 50%).Thus the research of p53-independent pathway in cell apoptosis may ultimately provide new therapeutic opportunities for many cancers.It has been shown that Caspase 2,p73,p63,and NF-κB-related signaling pathways are involved in DNA damage-induced,p53-independent cell apoptosis.This article reviews the recent research progress in these signaling pathways.

Key wordsDNA damage      Genes,p53      Signal transduction      p53      cell apoptosis      p53-independent pathway     
Received: 22 March 2012      Published: 25 March 2013
CLC:  R 730.2  
Cite this article:

ZHANG Xiao-Yun, JIANG Ying, YANG Jun. p53-independent signaling pathway in DNA damage-induced cell apoptosis. Journal of ZheJiang University(Medical Science), 2013, 42(2): 217-223.

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p53在DNA损伤诱导细胞凋亡中发挥关键作用,但p53基因在大多数肿瘤细胞中易发生突变,突变率可超过50%。目前研究发现,p73、p63、Caspase 2、NF-κB等蛋白介导的信号通路能够在p53非依赖的DNA损伤诱导细胞凋亡中发挥作用。因此,有必要对p53非依赖信号通路近年来的研究进展作一综述,为癌症治疗提供新的思路。

关键词: DNA损伤,  基因,  p53,  信号传导,  p53,  细胞凋亡,  p53非依赖信号通路 


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