Please wait a minute...
Journal of ZheJiang University(Medical Science)  2013, Vol. 42 Issue (2): 192-196    DOI: 10.3785/j.issn.1008-9292.2013.02.010
    
Comparison of skin sympathetic reaction in patients with generalized anxiety disorder and with major depression disorder
JIANG Hong, WANG Ling, WANG Xin-Ling, FENG Rui, ZHANG Ying-Chun, TU Ling-Ling, CHEN Wei
Department of Psychiatry,Sir Run Run Shaw Hospital,Zhejiang University School of Medicine,Hangzhou 310016,China
Download: HTML (   PDF(885KB)
Export: BibTeX | EndNote (RIS)      

Abstract  

Objective: To compare skin sympathetic response(SSR) between patients with generalized anxiety disorder(GAD) and patients with major depression disorder(MDD).
Methods: The latency and amplitude of SSR wave were measured in 30 GAD patients and 30 MDD patients,before and after 8-week treatment of anti-anxiety or anti-depression drugs.Thirty age and sex-matched healthy subjects served as healthy controls(HC).
Results: Before the treatment,the latency of SSR in GAD patients was significantly shorter than that in HC group,while the amplitude was significantly higher than that in the HC(P<0.05).In MDD group,the latency before the treatment was significantly longer than that in the HC,while the amplitude was significantly lower than that in the HC(P<0.05).After treatment,the latency of SSR in GAD group was extended compared to the baseline level,and close to the level of the HC.The amplitude of SSR in GAD group became lower after treatment,but still higher than that of control group.The latency of SSR in MDD patients was significantly shorter after treatment compared to baseline level(P<0.05).In addition,the latency of SSR in MDD group was still longer than that in GAD group(P<0.05); meanwhile,the amplitude of SSR in MDD group was significantly lower that in GAD group(P<0.001).SSR parameters were positively correlated with HAMA and HAMD scores with a correlation coefficient of 0.57 and 0.73,respectively.
Conclusion: There are significant differences in SSR parameters between patients with GAD and patients with MDD,indicating that SSR can be used as an objective index to distinguish anxiety from depression.



Key wordsAnxiety disorders      Depression      Depressive disorder      Manifest anxiety scale      Psychiatric status rating scales      Sympathetic skin response      Hamilton anxiety scale      Hamilton depressive scale     
Received: 09 December 2011      Published: 25 March 2013
CLC:  R 749.72  
Corresponding Authors: 陈炜(1963-),男,大学本科,主任医师,主要从事情感与认知疾病的诊断与治疗研究     E-mail: srrcw@zju.edu.cn
Cite this article:

JIANG Hong, WANG Ling, WANG Xin-Ling, FENG Rui, ZHANG Ying-Chun, TU Ling-Ling, CHEN Wei. Comparison of skin sympathetic reaction in patients with generalized anxiety disorder and with major depression disorder. Journal of ZheJiang University(Medical Science), 2013, 42(2): 192-196.

URL:

http://www.zjujournals.com/med/10.3785/j.issn.1008-9292.2013.02.010     OR     http://www.zjujournals.com/med/Y2013/V42/I2/192


广泛性焦虑症与抑郁症患者皮肤交感反应对照研究

目的:探讨广泛性焦虑症(GAD)与抑郁症(MDD)患者皮肤交感反应(SSR)的差异。
方法:对30例GAD患者、30例MDD患者,分别在治疗前及治疗8周后检测 SSR的潜伏期与波幅,并与30例正常对照组(HC)比较。
结果:GAD组治疗前SSR潜伏期低于HC组,波幅明显高于HC组,差异均有显著性意义(P<0.05);MDD组治疗前潜伏期比HC组明显延长,波幅明显低平,差异均有显著性意义(P<0.05),而且有2例未引出波形。经治疗后,GAD组潜伏期水平较治疗前延长,接近于对照组水平;波幅较治疗前降低,但高于对照组(P>0.05);MDD组潜伏期较治疗前降低(P<0.05),差异均有显著性意义。MDD组的SSR潜伏期明显延长,GAD组潜伏期缩短,两组比较差异有统计学意义(P<0.05);MDD组波幅明显低平,而GAD组波幅明显增高,两组比较差异有统计学意义(P<0.001)。相关分析显示,SSR各参数与HAMA和HAMD呈正相关,相关系数分别为0.57和0.73。
结论:GAD与MDD在SSR的电生理检测方面有显著性差异。


关键词: 广泛性焦虑,  抑郁症,  表现焦虑量表,  精神病状态评定量表,  皮肤交感反应,  汉密尔顿抑郁量表,  汉密尔顿焦虑量表 

[1]BOETTQER M K,GREINER W,RACHOW T,et al.Sympathetic skin response following painful electrical stimulation is increase in major depression
[J].Pain,2010,149(1):130-134.

[2]THAYER J F,FRIEDMAN B H,BORKOVEC T D.Autonomic Characteristic of Generalized Anxiety Disorder and Worry
[J].Biol Psychiatry,1996,39(4):255-266.

[3]ZAJECKA J M,ROSS J S.Management of comorbid anxiety and depression
[J].J Clin Psychiatry,1995,56(2):10-13.

[4]WAHLESTEDT C,PICH EM,KOOB G F,et al.Modulation of anxiety and neuropeptide Y-Y1 receptors by antisense oligodexynucleotides
[J].Science,1993,259(5094):528-531.

[5]HUNT C,SLADE T,ANDREWS G.Generalized Anxiety Disorder and major depressive disorder comorbidity in the National Survey of Mental Health and Well-Being
[J].Depress Anxiety,2004,20(1):23-31.

[6]BRAMBILLA F,MAGGIONI M.Blood levels of cytokines in elderly patients with major depressive disorder
[J].Acta Psychiatr Scand,1998,97(4):309-313.

[7]ZHANG Jinbei,HUANG Xingbing,GUAN Nianhong(张晋碚,黄兴兵,关念红).A controlled study of serum immunological,endocrinological and monoamine transmitter levels in patients with generalized anxiety disorder and major depression
[J].Chinese Journal of Psychiatry(中华精神科杂志),2004,37(4):211-213.(in Chinese)

[8]OU Hongxia,CHEN Ping,GUO Shuwan,et al(偶红霞,陈平,郭苏皖,等).The comparison study of polysomnography and P300 in patients with depression,anxiety disorder or obsessive-compulsive disorder
[J].Chinese Journal of Psychiatry(中华精神科杂志),2005,38(2):109-112.(in Chinese)

[9]ZHENG Xuning,CHEN Wei, ZHANG Lingju(郑旭宁,陈炜,张玲菊).Clinical significance of event related potential(P300) and sympathetic response in patients with depression
[J].Chinese Journal of Psychiatry(中华精神科杂志),2003,36(3):142.(in Chinese)

[10]BI Yong,CHEN Wei,Shen Jue,et al(毕涌,陈炜,沈珏,等).A Study Of Skin Sympathetic reaction in patient with depression for the first time
[J].Chinese Journal of Nervous and mentaldiseases(中国神经精神疾病杂志),2008,34(8):501-503.(in Chinese)

[11]AGELINK M W,BOZ C,ULLRICH H,et al.Relationship between major depression and heart rate variability.Clinical consequences and implications for antidepressive treatment
[J].Psychiatry Res,2002,15,113(1-2):139-149.

[12]POST R M.Transduction of psychosocial stress into the neurobiology of recurrent affective disorder
[J].Am J Psychiatry,1992,149(8): 999-1010.
[1] SHEN Dan, WANG Fangfang, JIANG Zhou, QU Fan. Long-term effects of polycystic ovary syndrome on the offspring[J]. Journal of ZheJiang University(Medical Science), 2017, 46(3): 300-304.
[2] WEI Bo,SHAO Yan-qi,MAO Shan-ying,DING Mei-ping. Clinical survey on neuropathic pain in neurological outpatient department[J]. Journal of ZheJiang University(Medical Science), 2014, 43(1): 89-93.
[3] LIU Jianxiang,FANG Yinquan,WEI Zhengxi,YANG Xingqiao,ZENG Linghui. Synergic antidepressive effect of quercetin and Hypericum perforatum extract in mice[J]. Journal of ZheJiang University(Medical Science), 2013, 42(6): 615-619.
[4] LIU Weibo,YU Hualiang,JIANG Biao,ZHENG Leilei,YU Shaohua,PAN Bing,YU Risheng. Correlation of neurochemical metabolism with memory function in young adult patients with first-episode depression studied with proton magnetic resonance spectroscopy[J]. Journal of ZheJiang University(Medical Science), 2013, 42(4): 450-.
[5] ZHOU Lei, LOU Min, ZHENG Shui-Hong, LI Jie. Analysis of 1H-MRS in patients with depression after basal ganglia infarction[J]. Journal of ZheJiang University(Medical Science), 2013, 42(2): 205-211.
[6] . Research progress on role of ghrelin in brain[J]. Journal of ZheJiang University(Medical Science), 2012, 41(6): 689-695.
[7] . Natural outcome and risk-prediction model of late-life depression[J]. Journal of ZheJiang University(Medical Science), 2012, 41(6): 653-658.
[8] . Alterations of plasma aspartic acid,glycine and asparagine levels in patients with major depressive disorder[J]. Journal of ZheJiang University(Medical Science), 2012, 41(2): 132-138.
[9] . Effect of venlafaxine on cognitive function and hippocampal brain-derived neurotrophic factor expression in rats with post-stroke depression[J]. Journal of ZheJiang University(Medical Science), 2011, 40(5): 527-534.
[10] . Research progress on barrel cortex and its plasticity[J]. Journal of ZheJiang University(Medical Science), 2011, 40(3): 332-337.
[11] . Repetitive transcranial magnetic stimulation combined with antidepressant medication in treatment of first-episode patients with major depression[J]. Journal of ZheJiang University(Medical Science), 2011, 40(3): 286-290.
[12] .
Glycometabolism of patients with depression at first episode
[J]. Journal of ZheJiang University(Medical Science), 2011, 40(2): 213-216.
[13] . Advances in application of deep brain stimulation in treatment of neuropsychological diseases[J]. Journal of ZheJiang University(Medical Science), 2009, 38(6): 549-558.