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Journal of ZheJiang University(Medical Science)  2010, Vol. 39 Issue (2): 174-180    DOI: 10.3785/j.issn.1008-9292.2010.02.011
Value of ~(18)F-FDG-PET/CT in diagnosis of classic fever of unknown origin
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Objective: To evaluate the application of ~(18)F-FDG PET/CT in diagnosis of classic fever of unknown origin. Methods: A total of 27 consecutive patients with classic fever of unknown origin (FUO) (19 men,8 women; aged 24-82 y) underwent ~(18)F-FDG PET/CT scans.The images were interpreted by visual inspection and semiquantitative analysis (standardized uptake value,SUV).Final diagnosis was based on histopathology or clinical follow-up. Results: The cause of FUO was confirmed by followed investigations in 21 of 27 cases after PET/CT scan,including 10 cases of infection,4 of noninfectious inflammation,4 of malignancies and 3 of miscellaneous disorders; and remaining 6 cases were still confirmed FUO.The sensitivity,specificity,positive predictive value,negative predictive value and accuracy were 100.0;,83.3;,83.3;,100.0; and 96.3;,respectively. Conclusion: For patients with fever of unknown origin,~(18)F-FDG-PET/CT can be a sensitive,reliable imaging modality.It is suggested that ~(18)F-FDG-PET/CT should be considered earlier in detecting the causes of FUO,which is difficultly diagnosed by conventional modalities.

Key wordsFever of unknown origin/diag      Fever of unknown origin/pathol      Flurodeoxyglucose F18      Positron-emission tomography      Tomography,X-ray computed      Follow-up studies      
Published: 25 March 2010
Cite this article:

. Value of ~(18)F-FDG-PET/CT in diagnosis of classic fever of unknown origin. Journal of ZheJiang University(Medical Science), 2010, 39(2): 174-180.

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FDG PET/CT对经典型不明原因发热的诊断价值

目的:探讨FDG PET/CT在经典型不明原因发热中的诊断价值.方法:对在2007年10月至2009年10月间27例(男性19例,女性8例)经典型不明原因发热病例,行FDG PET/CT显像,PET/CT图像结果判断应用目测法和半定量分析方法.最终诊断包括病理学检查或临床随访.结果:纳入本研究共27例不明原因发热患者,行PET/CT检查后经病理穿刺或病例随访证实,引起不明原因发热的病因共21例,其中包括感染10例,肿瘤性疾病(淋巴瘤)4例,非感染性炎症4例,其他类型3例,未能发现病因6例.FDG PET/CT诊断真阳性21例,假阳性1例,假阴性0例,真阴性5例.灵敏度100;,特异性83.3;;阳性预测值95.5;,阴性预测值100;;准确性96.3;.结论:在诊断不明原因发热患者中,FDG PET/CT显像是灵敏可靠的诊断方法,建议常规检查未能发现病灶或不能确诊的病例,可尽早行FDG PET/CT显像.

关键词: 发热,原因不明/诊断,  发热,原因不明/病理学,  氟脱氧葡萄糖F18,  正电子发射断层显像术,  体层摄影术,X线计算机,  随访研究 
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