The assessment of cardiac damage by echocardiography was made in 20 patients with dilated cardiomyopathy confirmed by clinical study. Compared with normal subjects,patients with dilated cardiomyopathy had severe abnormality in cardiac strugture, function, wall stress and LVEDP.The statistical analysis revealed positive correlation between EDV and LVMW, r=0.84(P<0.001) and negative correlation between SWI and SVR,r=-0.73(P<0.01);EDσ and RWT,r=-0.70(P<0.001); ESσ and FS, r=-0.46(P<0.05). It demonstrated:1. Dilated cardiomyopathy had a higher preload(EDV) with afterload(ESσ) mismatched,which could play an important role in accelerating the disease. 2. Relative wall thickness decrease could lead to increase of left ventricular wall stress which indicated that hypertrophy of the heart muscle did not compensate enough. 3. LVEDP of DCM was higher.