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| CARDIOPROTECTIVE EFFECT OF REPEATED BRIEF ISCHEMIC PRECONDITIONING |
| Shen Yueliang1, Xia Qiang1, Luo Jiangeng1, et al |
1. Department of Physiclogy, Zhejiang Medical University;
2. Department of physiology, Faculty of Medicine, The University of Hong Kong |
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Abstract The aim of the present study is to determine the protective effect of repeated brief ischemic preconditioning(IP) on myocardium in the isolated Langendorff perfusion model of the rat heart.The results showed that there was no arrhythmia of spontaneous ventricular fibrillation during the episode of repeated brief ischemic preconditioning. And during the sustained ischemia and reperfusion following ischemic preconditioning,ventricular fibrillation threshold increased and the incidence of arrhythmias reduced significantly.It indicated that repeated brief ischemic preconditioning could provide a cardioprotective effect on the isolated rat heart.
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Received: 05 April 1995
Published: 25 November 1995
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多次短暂缺血预处理的心肌保护作用
本实验应用离体大鼠Langendorff灌流模型,研究连续多次短暂缺血预处理(IP)对心肌的保护作用。结果显示:在多次短暂IP期间,ERP短时延长,无自发性心室颤动发生。经IP后的再次缺血-复灌期间,心室颤动阈升高,心律失常发生率明显降低。提示在离体大鼠心脏中,多次短暂IP对心肌具有保护作用。
关键词：
心肌短暂缺血/病理生理学,
有效不应期,
心室颤动阈,
心律失常
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