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Journal of ZheJiang University(Medical Science)  1995, Vol. 24 Issue (1): 21-23    DOI: 10.3785/j.issn.1008-9292.1995.01.007
    
STUDY ON CONTENTS OF PLASMA 6-KETO-PGF ANDTXB2 IN PATIENTS WITH MIGRAINE DURING HEADACHE-FREE PERIOD
Yu Yuxing, Xie Tao, Pan Yizheng
Department of Neurology, The Second Affiliated Hospital, Zhejiang Medical University
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Abstract  

The plasma contents of 6-keto-PGF,a stable metabolite of prostacyclin and TXB2,a stable metabolite of thromboxane A2 were measured in 23 patients with migraine during headache-free period and the results were compared with those of 20 normal subjects matched with age and sex.The 6-keto-PGFdecreased significantly in the migraine group.No difference was shown in TXB2.These data suggest that lower level of 6-keto-PGFis the background for its onset and recurrence but TXB2 not significant enough.



Key wordsMigraine/etiol      6-ketoprostaglandin F1 alpha/blood      Thromboxane B2/blood     
Received: 23 March 1994      Published: 25 January 1995
Cite this article:

Yu Yuxing, Xie Tao, Pan Yizheng. STUDY ON CONTENTS OF PLASMA 6-KETO-PGF ANDTXB2 IN PATIENTS WITH MIGRAINE DURING HEADACHE-FREE PERIOD. Journal of ZheJiang University(Medical Science), 1995, 24(1): 21-23.

URL:

https://www.zjujournals.com/med/10.3785/j.issn.1008-9292.1995.01.007     OR     https://www.zjujournals.com/med/Y1995/V24/I1/21


偏头痛患者发作间歇期血6-keto-PGF和TXB2含量的观察

通过对23例发作间歇期偏头痛患者及20名年龄、性别匹配的正常对照组血6-keto-PGF(6-酮前列腺素F)和TXB2(血栓素B2)含量的测定,发现偏头痛患者的6-keto-PGF含量较对照组低(P<0.01),TXB2含量则两者无差异。作者认为低水平的6-keto-PGF是偏头痛的发作及复发的重要物质基础之一,而TXB2则意义不大。


关键词: 偏头痛/病因学,  6-酮前列腺素F1&alpha,  /血液,  血栓素B2/血液 
[1] Lin Youmin, Kang Manli. Relationship between Plasma Levels of TXA2、PGI2 and Pulmonary Artery Hypertension in Congenital Ventricular Septal Defect[J]. Journal of ZheJiang University(Medical Science), 1999, 28(2): 62-64.
[2] Zhang Xiaogang, Lou Fuqing, Lu Junsheng, et al. PLATELET AGGREGATION AND THE LEVEL OF PLASMA THROMBOXANE B2 IN PATIENTS WITH OLD MYOCARDIAL INFARCTION[J]. Journal of ZheJiang University(Medical Science), 1990, 19(2): 56-58.