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J Zhejiang Univ (Med Sci)  2021, Vol. 50 Issue (3): 390-395    DOI: 10.3724/zdxbyxb-2021-0190
    
Research advance of Nrf2 on atherosclerosis by regulating vascular smooth muscle cell
ZHUANG Wenwen1(),YANG Yongqi1,LI Hongliang1,2,LIANG Jingyan1,2,*()
1. Medical College, Yangzhou University, Yangzhou 225000, Jiangsu Province, China;
2. Institute of Translational Medicine, Yangzhou University, Yangzhou 225000, Jiangsu Province, China
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Abstract  

Atherosclerosis is a common pathological change in cardiovascular disease. Vascular smooth muscle cell is the main source of plaque cell and extracellular matrix, and nuclear factor-erythroid 2-related factor 2 (Nrf2) is a key transcription factor regulating the function of vascular smooth muscle cell. In the process of atherosclerosis, Nrf2 signaling pathway has the following regulatory effects on vascular smooth muscle cell: regulating the phenotype of vascular smooth muscle cell to change to the direction conducive to the alleviation of disease progression; inhibiting the proliferation and migration of vascular smooth muscle cell; mitigating the level of blood lipid; alleviating vascular smooth muscle cell calcification, aging and apoptosis process. This article reviews the specific mechanisms of Nrf2 regulating atherosclerosis, such as phenotypic transformation, proliferation and migration, lipid metabolism, calcification, aging and apoptosis in atherosclerosis, in order to provide a basis for understanding the molecular mechanism of atherosclerosis development and finding therapeutic targets.



Key wordsAtherosclerosis      Vascular smooth muscle cell      Nuclear factor-erythroid 2- related factor 2      Review     
Received: 20 December 2020      Published: 16 August 2021
CLC:  R543.5  
Corresponding Authors: LIANG Jingyan     E-mail: zhuangwenwen_epig@163.com;jyliang@yzu.edu.cn
Cite this article:

ZHUANG Wenwen,YANG Yongqi,LI Hongliang,LIANG Jingyan. Research advance of Nrf2 on atherosclerosis by regulating vascular smooth muscle cell. J Zhejiang Univ (Med Sci), 2021, 50(3): 390-395.

URL:

http://www.zjujournals.com/med/10.3724/zdxbyxb-2021-0190     OR     http://www.zjujournals.com/med/Y2021/V50/I3/390


动脉粥样硬化过程中核因子E2相关因子2对血管平滑肌细胞的调控作用

动脉粥样硬化是心血管疾病中常见的病理改变。血管平滑肌细胞是斑块细胞和细胞外基质的主要来源,而核因子E2相关因子2(Nrf2)是调控血管平滑肌细胞功能的关键转录因子。在动脉粥样硬化过程中,Nrf2信号通路对血管平滑肌细胞具有以下调控作用:调控血管平滑肌细胞表型向有利于缓解疾病进程的方向转变,抑制血管平滑肌细胞增殖和迁移,降低血脂水平,以及缓解血管平滑肌细胞钙化、衰老和凋亡等过程。本文对现阶段Nrf2在动脉粥样硬化中调控血管平滑肌细胞表型转换、增殖和迁移、脂代谢、钙化、衰老和凋亡等过程的具体机制进行综述,以期为深入理解动脉粥样硬化发生发展的分子机制及寻找治疗靶点提供依据。


关键词: 动脉粥样硬化,  血管平滑肌细胞,  核因子E2相关因子2,  综述 
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