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| Advances in the role of silence information regulator family in pathological pregnancy |
GE Yingzhou12( ),LIU Xinmei12,HUANG Hefeng1,23,*() |
1. International Peace Maternity and Child Health Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai 200030, China; 2. Shanghai Key Laboratory of Embryo Original Diseases, Shanghai 200030, China;
3. Women’s Hospital, Zhejiang University School of Medicine, Hangzhou 310006, China |
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Abstract Aberrant maternal inflammation and oxidative stress are the two main mechanisms of pathological pregnancy. The silence information regulator (sirtuin) family is a highly conserved family of nicotinamide adenine dinucleotide (NAD)-dependent deacylases. By regulating the post-translational modification of proteins, sirtuin is involved in various biological processes including oxidative stress and inflammation. Nowadays, emerging evidence indicates that sirtuin may be closely related to the occurrence and development of pathological pregnancy. The down-regulation of sirtuin can cause spontaneous preterm delivery by promoting uterine contraction and rupture of fetal membranes, cause gestational diabetes mellitus through promoting oxidative stress and affecting the activity of key enzymes in glucose metabolism, cause preeclampsia by reducing the proliferation and invasion ability of trophoblasts, cause intrahepatic cholestasis of pregnancy by promoting the production of bile acids and T helper 1 cell (Th1) cytokines, and cause intrauterine growth restriction through inducing mitochondrial dysfunction. Moreover, the expression and activation of sirtuin can be modulated through dietary interventions, thus sirtuin is expected to become a new target for the prevention and treatment of pregnancy complications. This article reviews the role of the sirtuin family in the occurrence and development of pathological pregnancy and its influence on the development of the offspring.
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Received: 29 January 2021
Published: 16 August 2021
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Corresponding Authors:
HUANG Hefeng
E-mail: geyingzhou@163.com;huanghefg@hotmail.com
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沉默信息调节因子家族参与病理妊娠的研究进展
异常的母体炎症反应及氧化应激是病理妊娠的两大致病机制。沉默信息调节因子（sirtuin）家族是一类高度保守的烟酰胺腺嘌呤二核苷酸依赖性脱酰基酶，通过调控蛋白的翻译后修饰，广泛参与包括氧化应激和炎症反应在内的多种生理过程，与病理妊娠的发生发展密切相关。其表达下降可通过促进子宫收缩及胎膜破裂引起自发性早产、通过干扰糖代谢关键酶活性及促进氧化应激诱发妊娠糖尿病、通过降低滋养细胞增殖及侵袭能力导致子痫前期、通过促进辅助性T细胞1型细胞因子及胆汁酸的生成引起妊娠肝内胆汁淤积症，也可通过诱发线粒体功能障碍导致胎儿生长受限。此外，sirtuin的表达及活化可通过饮食调节，故未来有望成为妊娠相关疾病预防和治疗的新靶点。本文回顾了sirtuin家族在病理妊娠发生发展中的作用及其对此类患者子代发育影响的最新研究进展。
关键词：
沉默信息调节因子,
早产,
妊娠糖尿病,
子痫前期,
妊娠肝内胆汁淤积症,
胎儿生长受限,
综述
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