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J Zhejiang Univ (Med Sci)  2021, Vol. 50 Issue (3): 403-408    DOI: 10.3724/zdxbyxb-2021-0163
Progress on mitochondrial silence information regulator family in epilepsy
ZHU Feng1(),XIANG Yingchun2,ZENG Linghui1,*()
1. School of Medicine, Zhejiang University City College, Hangzhou 310015, China;
2. Department of Pharmacy, Zhejiang Hospital, Hangzhou 310012 ,China
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SIRT3, SIRT4 and SIRT5 are located in mitochondria and also known as mitochondrial sirtuins. They play important roles in regulating many cellular functions including cell survival, cell cycle or apoptosis, DNA repair and metabolism. Mitochondrial sirtuins are involved in the protection of mitochondrial integrity and energy metabolism under stress regulating the expression of neurotransmitter receptors, neurotrophins, extracellular matrix proteins and various transcription factors, thus involved in epileptogenesis triggered by both genetic or acquired factors. Here we review research progress on the actions of mitochondrial sirtuin in epilepsy; and discuss the challenges and perspectives of mitochondrial sirtuin as a potential therapeutic target for epilepsy.

Key wordsMitochondrion      Silence information regulator      Epilepsy      Oxidative stress      Mechanism      Review     
Received: 20 October 2020      Published: 16 August 2021
CLC:  R742.1  
Corresponding Authors: ZENG Linghui     E-mail:;
Cite this article:

ZHU Feng,XIANG Yingchun,ZENG Linghui. Progress on mitochondrial silence information regulator family in epilepsy. J Zhejiang Univ (Med Sci), 2021, 50(3): 403-408.

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关键词: 线粒体,  沉默信息调节因子,  癫痫,  氧化应激,  机制,  综述 
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