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J Zhejiang Univ (Med Sci)  2021, Vol. 50 Issue (3): 396-402    DOI: 10.3724/zdxbyxb-2021-0146
Research progress on proteasome subunits in regulating occurrence and development of hepatocellular carcinoma
HU Jingyi(),WANG Qingqing,LIU Yang()
Institute of Immunology, Zhejiang University School of Medicine, Hangzhou 310058, China
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Proteasome is the eukaryotic organelle responsible for degradation of short-lived proteins and involved in maintaining cellular protein homeostasis. It has been reported that during the occurrence and development of hepatocellular carcinoma (HCC), the regulatory particle subunits of proteasome regulate a series of tumor-related proteins, and proliferation, survival-associated signaling molecules, including PTEN gene, P53, Bcl-2, Bcl-2 interacting mediator of cell death (Bim), cyclin-dependent kinase 4(CDK4), transforming growth factor β receptor (TGFBR), E2F1, growth factor receptor-bound protein 2 (GRB2) . Meanwhile, these subunits regulate some tumor-associated pathway protein, such as signal transducer and activator of transcription 3 (STAT3) and protein kinase B (AKT), inducing their malfunction to promote the occurrence, proliferation, invasion and metastasis of HCC. The core particle subunits are more to perform the degradation of HCC-related proteins, so inhibitors targeting the core particle show a good anti-tumor effect. This review summarizes the current research progress on the regulation and mechanism of proteasome subunits in promoting the occurrence and development of HCC.

Key wordsProteasome      Proteasome regulatory particle      Proteasome core particle      Hepatocellular carcinoma      Mechanism      Review     
Received: 11 January 2021      Published: 16 August 2021
CLC:  R735.7  
Corresponding Authors: LIU Yang     E-mail:;
Cite this article:

HU Jingyi,WANG Qingqing,LIU Yang. Research progress on proteasome subunits in regulating occurrence and development of hepatocellular carcinoma. J Zhejiang Univ (Med Sci), 2021, 50(3): 396-402.

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关键词: 蛋白酶体,  蛋白酶体调节颗粒,  蛋白酶体核心颗粒,  肝细胞癌,  机制,  综述 
Figure 1 Mechanisms of proteasome regulatory particles subunits in HCC
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