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J Zhejiang Univ (Med Sci)  2021, Vol. 50 Issue (2): 267-276    DOI: 10.3724/zdxbyxb-2021-0110
Research progress on transient receptor potential melastatin 2 channel in nervous system diseases
YING Yingchao(),JIANG Peifang()
Department of Neurology, the Children’s Hospital, Zhejiang University School of Medicine, Hangzhou 310052, China
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Transient receptor potential M2 (TRPM2) ion channel is a non-selective cationic channel that can permeate calcium ions, and plays an important role in neuroinflammation, ischemic reperfusion brain injury, neurodegenerative disease, neuropathic pain, epilepsy and other neurological diseases. In ischemic reperfusion brain injury, TRPM2 mediates neuronal death by modulating the different subunits of glutamate N-methyl-D-aspartic acid receptor in response to calcium/zinc signal. In Alzheimer’s disease, TRPM2 is activated by reactive oxygen species generated by β-amyloid peptide to form a malignant positive feedback loop that induces neuronal death and is involved in the pathological process of glial cells by promoting inflammatory response and oxidative stress. In epilepsy, the TRPM2-knockout alleviates epilepsy induced neuronal degeneration by inhibiting autophagy and apoptosis related proteins. The roles of TRPM2 channel in the pathogenesis of various central nervous system diseases and its potential drug development and clinical application prospects are summarized in this review.

Key wordsTransient receptor potential melastain 2      Nervous system diseases      Ischemia-reperfusion brain injury      Alzheimer’s disease      Epilepsy      Juvenile myoclonic epilepsy      Review     
Received: 15 October 2020      Published: 18 June 2021
CLC:  R741  
Corresponding Authors: JIANG Peifang     E-mail:;
Cite this article:

YING Yingchao,JIANG Peifang. Research progress on transient receptor potential melastatin 2 channel in nervous system diseases. J Zhejiang Univ (Med Sci), 2021, 50(2): 267-276.

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瞬时受体电位 M2 型离子通道在神经系统疾病中的作用研究进展

瞬时受体电位 M2 型(TRPM2)离子通道是可渗透钙离子的非选择性阳离子通道,在神经炎症、缺血再灌注脑损伤、神经退行性病变、神经病理性疼痛、癫痫等多种神经系统疾病中发挥重要作用。在缺血再灌注脑损伤中,TRPM2 通过调节谷氨酸离子 N-甲基-D-天冬氨酸受体不同亚基、响应钙离子/锌离子信号,介导神经元死亡。在阿尔茨海默病中,TRPM2 被β-淀粉样肽生成的活性氧激活形成恶性正反馈循环诱导神经元死亡,并在胶质细胞中通过促进炎症反应和氧化应激参与其病理过程。在癫痫中,TRPM2 基因敲除通过抑制自噬和凋亡相关蛋白,减轻癫痫引起的神经元变性。本文总结了近年来 TRPM2 通道在多种中枢神经系统疾病发病机制中的作用及其潜在的药物研发和临床应用前景。

关键词: 瞬时受体电位 M2 型,  神经系统疾病,  缺血再灌注脑损伤,  阿尔茨海默病,  癫痫,  青少年肌阵挛癫痫,  综述 
Figure 1 The mechanism of NMDAR-related TRPM2 channels mediating ischemic reperfusion brain injury
Figure 2 Common mechanisms of neuronal death induced by TRPM2 in different types of neurological diseases
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