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浙江大学学报（医学版）
浙江大学学报（医学版）  2022, Vol. 51 Issue (5): 613-625    DOI: 10.3724/zdxbyxb-2022-0603
细胞因子     
生长因子在眼的发育及眼部疾病调控中的作用
王晓杰,惠琦,金子,饶凤琴,靳磊,余丙洁,BANDA Joshua,李校堃
温州医科大学药学院，浙江 温州 325035
Roles of growth factors in eye development and ophthalmic diseases
WANG Xiaojie,HUI Qi,JIN Zi,RAO Fengqin,JIN Lei,YU Bingjie,BANDA Joshua,LI Xiaokun
School of Pharmaceutical Sciences, Wenzhou Medical University, Wenzhou 325035, Zhejiang Province, China
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摘要：

生长因子是一类由多种细胞分泌的活性物质，作为信使调控细胞的迁移、增殖和分化。多种生长因子参与眼组织的发育及眼部疾病的生理、病理过程。血管内皮生长因子、碱性成纤维细胞生长因子等介导糖尿病性视网膜病、脉络膜新生血管、白内障、糖尿病性黄斑水肿以及其他视网膜疾病的发生和发展。神经生长因子、睫状神经营养因子、胶质细胞源性神经营养因子、色素上皮衍生因子、粒细胞集落刺激因子等对视神经损伤有较好的修复作用。生长因子还与近视的发病密切相关，成纤维细胞生长因子、转化生长因子-β、胰岛素样生长因子影响巩膜厚度变化并调控近视的发生与发展。本文综述了生长因子参与眼的发育和眼部病理生理过程的研究进展，旨在揭示生长因子与眼部疾病的关联，为生长因子在眼科领域的应用提供思路。
关键词： 生长因子;  眼的发育;  眼部疾病;  眼科学;  综述    
Abstract:

Growth factors are active substances secreted by a variety of cells, which act as messengers to regulate cell migration, proliferation and differentiation. Many growth factors are involved in the eye development or the pathophysiological processes of eye diseases. Growth factors such as vascular endothelial growth factor and basic fibroblast growth factor mediate the occurrence and development of diabetic retinopathy, choroidal neovascularization, cataract, diabetic macular edema, and other retinal diseases. On the other hand, growth factors like nerve growth factor, ciliary neurotrophic factor, glial cell line-derived neurotrophic factor, pigment epithelial-derived factor and granulocyte colony-stimulating factor are known to promote optic nerve injury repair. Growth factors are also related to the pathogenesis of myopia. Fibroblast growth factor, transforming growth factor-β, and insulin-like growth factor regulate scleral thickness and influence the occurrence and development of myopia. This article reviews growth factors involved in ocular development and ocular pathophysiology, discusses the relationship between growth factors and ocular diseases, to provide reference for the application of growth factors in ophthalmology.
Key words: Growth factor    Eye development    Ophthalmic diseases    Ophthalmology    Review
收稿日期: 2022-03-01 出版日期: 2022-12-28
CLC:  R77  
基金资助: 浙江省“尖兵”“领雁”研发攻关计划（2022C03110）
通讯作者: 李校堃   
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王晓杰
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金子
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余丙洁
BANDA Joshua
李校堃

引用本文:

王晓杰,惠琦,金子,饶凤琴,靳磊,余丙洁,BANDA Joshua,李校堃. 生长因子在眼的发育及眼部疾病调控中的作用[J]. 浙江大学学报（医学版）, 2022, 51(5): 613-625.

WANG Xiaojie,HUI Qi,JIN Zi,RAO Fengqin,JIN Lei,YU Bingjie,BANDA Joshua,LI Xiaokun. Roles of growth factors in eye development and ophthalmic diseases. J Zhejiang Univ (Med Sci), 2022, 51(5): 613-625.

链接本文:

https://www.zjujournals.com/med/CN/10.3724/zdxbyxb-2022-0603    或    https://www.zjujournals.com/med/CN/Y2022/V51/I5/613

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