Please wait a minute...
浙江大学学报（医学版）
浙江大学学报（医学版）  2020, Vol. 49 Issue (1): 118-123    DOI: 10.3785/j.issn.1008-9292.2020.02.13
综述     
抗N-甲基-D-天冬氨酸受体脑炎患者脑电图特点的研究进展
刘晓晓(),郭莉琼,梁成*()
兰州大学第二临床医学院, 甘肃 兰州 730030
Research progress on electroencephalogram characteristics of anti-N-methyl-D-aspartate receptor encephalitis
LIU Xiaoxiao(),GUO Liqiong,LIANG Cheng*()
The Second Clinical Medical College, Lanzhou University, Lanzhou 730030, China
 全文: PDF(977 KB)   HTML( 6 )
摘要：

抗N-甲基-D-天冬氨酸（NMDA）受体脑炎是一种针对NMDA受体NR1亚基的自身免疫性疾病，早期以功能性损伤为主，脑电图检查通过记录脑电信号的变化，可以敏感地反映脑功能异常。抗NMDA受体脑炎较为常见的脑电图特点为慢波性异常、癫痫样放电、大量β活动、极度δ刷状波等。本文从上述脑电图模式的波形特点、起源部位、发生机制、临床价值等方面，综述抗NMDA受体脑炎患者的脑电图特点研究概貌。
关键词： 受体, N-甲基-D-天冬氨酸/脑炎;  自身免疫性/疾病;  脑电描记术;  脑电波/异常;  综述    
Abstract:

Anti-N-methyl-d-aspartate (NMDA) receptor encephalitis is a kind of autoimmune disease aiming at NR1 subunit of NMDA receptor. In the early stage, functional damage is the main cause. Electroencephalogram (EEG) can reflect the abnormal brain function by recording the changes of EEG signals. The common EEG patterns of anti NMDA receptor encephalitis are slow wave abnormality, epileptic discharge, a large number of β activity, extreme delta brush, etc. Here we review the waveform characteristics, origin, pathogenesis and clinical value of EEG in patients with NMDA receptor encephalitis.
Key words: Receptors, N-methyl-D-aspartate/encephalitis    Autoimmunity/disease    Electroencephalography    Brain waves/abnormal    Review
收稿日期: 2019-09-30 出版日期: 2020-06-08
CLC:  R742  
通讯作者: 梁成     E-mail: 287985748@qq.com;hongyan200107@126.com
作者简介: 刘晓晓(1993-), 女, 硕士研究生, 主要从事神经重症相关研究; E-mail:287985748@qq.com; https://orcid.org/0000-0001-6251-2894
服务　　
把本文推荐给朋友
加入引用管理器
E-mail Alert
RSS
作者相关文章　　
刘晓晓
郭莉琼
梁成

引用本文:

刘晓晓,郭莉琼,梁成. 抗N-甲基-D-天冬氨酸受体脑炎患者脑电图特点的研究进展[J]. 浙江大学学报（医学版）, 2020, 49(1): 118-123.

LIU Xiaoxiao,GUO Liqiong,LIANG Cheng. Research progress on electroencephalogram characteristics of anti-N-methyl-D-aspartate receptor encephalitis. J Zhejiang Univ (Med Sci), 2020, 49(1): 118-123.

链接本文:

http://www.zjujournals.com/med/CN/10.3785/j.issn.1008-9292.2020.02.13    或    http://www.zjujournals.com/med/CN/Y2020/V49/I1/118

1 DALMAU J , LANCASTER E , MARTINEZ-HERNANDEZ E et al. Clinical experience and laboratory investigations in patients with anti-NMDAR encephalitis[J]. Lancet Neurol, 2011, 10 (1): 63- 74
doi: 10.1016/S1474-4422(10)70253-2
2 GRESA-ARRIBAS N , TITULAER M J , TORRENTS A et al. Antibody titres at diagnosis and during follow-up of anti-NMDA receptor encephalitis:a retrospective study[J]. Lancet Neurol, 2014, 13 (2): 167- 177
doi: 10.1016/S1474-4422(13)70282-5
3 GABLE M , GLASER C . Anti-N-methyl-D-aspartate receptor encephalitis appearing as a new-onset psychosis:disease course in children and adolescents within the california encephalitis project[J]. Pediatr Neurol, 2017, 72:25- 30
doi: 10.1016/j.pediatrneurol.2017.01.023
4 MEI L P , LI L P , YE J et al. A special electroencephalography pattern might help in the diagnosis of antibody-positive encephalitis[J]. Chin Med J(Engl), 2015, 128 (18): 2474- 2477
doi: 10.4103/0366-6999.164932
5 KIRKPATRICK M P , CLARKE C D , SONMEZTURK H H et al. Rhythmic delta activity represents a form of nonconvulsive status epilepticus in anti-NMDA receptor antibody encephalitis[J]. Epilepsy Behav, 2011, 20 (2): 392- 394
doi: 10.1016/j.yebeh.2010.11.020
6 JOHNSON N , HENRY C , FESSLER A J et al. Anti-NMDA receptor encephalitis causing prolonged nonconvulsive status epilepticus[J]. Neurology, 2010, 75 (16): 1480- 1482
doi: 10.1212/WNL.0b013e3181f8831a
7 SCHMITT S E , PARGEON K , FRECHETTE E S et al. Extreme delta brush:a unique EEG pattern in adults with anti-NMDA receptor encephalitis[J]. Neurology, 2012, 79 (11): 1094- 1100
doi: 10.1212/WNL.0b013e3182698cd8
8 CARVAJAL F J , MATTISON H A , CERPA W . Role of NMDA receptor-mediated glutamatergic signaling in chronic and acute neuropathologies[J]. Neural Plast, 2016, 2016:2701526
doi: 10.1155/2016/2701526
9 李宁虎, 陈梓斌, 李静 et al. 抗NMDA受体脑炎临床及脑电图分析[J]. 中国实用神经疾病杂志, 2019, 22 (14): 1554- 1560
LI Ninghu , CHEN Zibin , LI Jing et al. Clinical and EEG analysis of anti-N-methyl-D-aspartic acid receptor encephalitis[J]. Chinese Journal of Practical Nervous Diseases, 2019, 22 (14): 1554- 1560
doi: 10.12083/SYSJ.2019.14.223
10 张艳, 刘刚, 姜梦迪 et al. 抗N-甲基-D-天冬氨酸受体脑炎患者的脑电图特点分析[J]. 中华神经科杂志, 2017, 50 (6): 419- 425
ZHANG Yan , LIU Gang , JIANG Mengdi et al. Characteristics of electroencephalogram in patients with anti-N-methyl-D-aspartate receptor encephalitis[J]. Chinese Journal of Neurology, 2017, 50 (6): 419- 425
doi: 10.3760/cma.j.issn.1006-7876.2017.06.004
11 SUTTER R , KAPLAN P W , CERVENKA M C et al. Electroencephalography for diagnosis and prognosis of acute encephalitis[J]. Clin Neurophysiol, 2015, 126 (8): 1524- 1531
doi: 10.1016/j.clinph.2014.11.006
12 VECIANA M , BECERRA J L , FOSSAS P et al. EEG extreme delta brush:An ictal pattern in patients with anti-NMDA receptor encephalitis[J]. Epilepsy Behav, 2015, 49:280- 285
doi: 10.1016/j.yebeh.2015.04.032
13 JEANNIN-MAYER S , ANDRé-OBADIA N , ROSENBERG S et al. EEG analysis in anti-NMDA receptor encephalitis:Description of typical patterns[J]. Clin Neurophysiol, 2019, 130 (2): 289- 296
doi: 10.1016/j.clinph.2018.10.017
14 GATAULLINA S , PLOUIN P , VINCENT A et al. Paroxysmal EEG pattern in a child with N-methyl-D-aspartate receptor antibody encephalitis[J]. Dev Med Child Neurol, 2011, 53 (8): 764- 767
doi: 10.1111/j.1469-8749.2011.03956.x
15 CHANSON E , BICILLI é , LAUXEROIS M et al. Anti-NMDA-R encephalitis:Should we consider extreme delta brush as electrical status epilepticus?[J]. Neurophysiol Clin, 2016, 46 (1): 17- 25
doi: 10.1016/j.neucli.2015.12.009
16 TRINKA E , LEITINGER M . Which EEG patterns in coma are nonconvulsive status epilepticus?[J]. Epilepsy Behav, 2015, 49:203- 222
doi: 10.1016/j.yebeh.2015.05.005
17 RODRIGUEZ RUIZ A , VLACHY J , LEE J W et al. Association of periodic and rhythmic electroencephalographic patterns with seizures in critically ill patients[J]. JAMA Neurol, 2017, 74 (2): 181- 188
doi: 10.1001/jamaneurol.2016.4990
18 GASPARD N , FOREMAN B P , ALVAREZ V et al. New-onset refractory status epilepticus:Etiology, clinical features, and outcome[J]. Neurology, 2015, 85 (18): 1604- 1613
doi: 10.1212/WNL.0000000000001940
19 柴晓洋, 王洁, 庞倩 et al. 自身免疫性脑炎相关性癫痫的研究进展[J]. 中华神经医学杂志, 2019, 18 (2): 207- 210
CHAI Xiaoyang , WANG Jie , PANG Qian et al. Recent advance in epilepsy associated with autoimmune encephalitis[J]. Chinese Journal of Neuromedicine, 2019, 18 (2): 207- 210
doi: 10.3760/cma.j.issn.1671-8925.2019.02.018
20 中华医学会神经病学分会脑电图与癫痫学组 . 非惊厥性癫痫持续状态的治疗专家共识[J]. 中华神经科杂志, 2013, 46 (2): 133- 137
Electroencephalogram and Epilepsy Group of Chinese Medical Association Neurology Branch . Expert consensus on the treatment of nonconvulsive status epilepticus[J]. Chinese Journal of Neurology, 2013, 46 (2): 133- 137
doi: 10.3760/cma.j.issn.1006-7876.2013.02.017
21 DA SILVA-JúNIOR F P , CASTRO L H , ANDRADE J Q et al. Serial and prolonged EEG monitoring in anti-N-Methyl-d-Aspartate receptor encephalitis[J]. Clin Neurophysiol, 2014, 125 (8): 1541- 1544
doi: 10.1016/j.clinph.2014.01.001
22 李华, 肖静, 吕俊兰 et al. 儿童抗N-甲基-D-天门冬氨酸受体脑炎12例临床及脑电图特点分析[J]. 中国实用儿科杂志, 2014, (2): 125- 128
LI Hua , XIAO Jing , LYU Junlan et al. The clinical and EEG characteristics of anti-N-methyl-D-aspartate receptor encephalitis in children[J]. Chinese Journal of Practical Pediatrics, 2014, (2): 125- 128
doi: 10.3760/cma.j.issn.0578-1310.2016.07.007
23 YILDIRIM M , KONUSKAN B , YALNIZOGLU D et al. Electroencephalographic findings in anti-N-methyl-d-aspartate receptor encephalitis in children:A series of 12 patients[J]. Epilepsy Behav, 2018, 78:118- 123
doi: 10.1016/j.yebeh.2017.09.022
24 VANHAERENTS S , STILLMAN A , INOA V et al. Early and persistent 'extreme delta brush' in a patient with anti-NMDA receptor encephalitis[J]. Epilepsy Behav Case Rep, 2014, 2:67- 70
doi: 10.1016/j.ebcr.2014.01.002
25 李华, 王晓慧, 方方 et al. 儿童抗N-甲基-D-天冬氨酸受体脑炎临床与脑电图分析[J]. 中华儿科杂志, 2016, 54 (7): 510- 514
LI Hua , WANG Xiaohui , FANG Fang et al. Clinical and electroencephalographic analysis of anti-N-methyl-D-aspartate receptor encephalitis in children[J]. Chinese Journal of Pediatrics, 2016, 54 (7): 510- 514
doi: 10.3760/cma.j.issn.0578-1310.2016.07.007
26 WANG J , WANG K , WU D et al. Extreme delta brush guides to the diagnosis of anti-NMDAR encephalitis[J]. J Neurol Sci, 2015, 353 (1-2): 81- 83
doi: 10.1016/j.jns.2015.04.009
27 ZHANG Y , LIU G , JIANG M D et al. Analysis of electroencephalogram characteristics of anti-NMDA receptor encephalitis patients in China[J]. Clin Neurophysiol, 2017, 128 (7): 1227- 1233
doi: 10.1016/j.clinph.2017.04.015
[1] 朱慧琦,应可净. 组织因子与肿瘤患者静脉血栓栓塞[J]. 浙江大学学报（医学版）, 2020, 49(6): 772-778.
[2] 林翠翠,陈正云,王春艳,席咏梅. 基于脂质组学的子宫内膜异位症生物标志物研究进展[J]. 浙江大学学报（医学版）, 2020, 49(6): 779-784.
[3] 李梦瑶,刘盼,柯越海,张雪. 放射性肺损伤中巨噬细胞作用机制的研究进展[J]. 浙江大学学报（医学版）, 2020, 49(5): 623-628.
[4] 韩雪,蒋国军,石巧娟. 降血糖药对内皮祖细胞作用的研究进展[J]. 浙江大学学报（医学版）, 2020, 49(5): 629-636.
[5] 段润平,许叶圣,郑利斌,姚玉峰. 病毒感染性眼病病原学诊断的研究进展[J]. 浙江大学学报（医学版）, 2020, 49(5): 644-650.
[6] 吴唯,徐键. 正五聚蛋白3在多囊卵巢综合征中的作用研究进展[J]. 浙江大学学报（医学版）, 2020, 49(5): 637-643.
[7] 徐清霖,楼国东,王甜甜,张力三. 发作性睡病的药物治疗进展[J]. 浙江大学学报（医学版）, 2020, 49(4): 419-424.
[8] 蒋沛然,王志萍. 模式生物神经轴突再生的研究进展[J]. 浙江大学学报（医学版）, 2020, 49(4): 500-507.
[9] 陈峻逸,杨翔,方学贤,王福俤,闵军霞. 铁死亡与重大慢性疾病[J]. 浙江大学学报（医学版）, 2020, 49(1): 44-57.
[10] 赵维霞,邹炜. 神经元树突形态建成分子机制的研究进展[J]. 浙江大学学报（医学版）, 2020, 49(1): 90-99.
[11] 王毅,卢韵碧. 多腺苷二磷酸核糖基化修饰与神经退行性变性疾病[J]. 浙江大学学报（医学版）, 2020, 49(1): 100-106.
[12] 俞卿, 熊秀芳, 孙毅. 靶向Cullin-RING E3泛素连接酶的抗肿瘤策略及相关药物研发进展[J]. 浙江大学学报（医学版）, 2020, 49(1): 1-19.
[13] 段玲艳,尹香菊,孟红恩,方学贤,闵军霞,王福俤. 铁稳态代谢表观遗传调控机制的研究进展[J]. 浙江大学学报（医学版）, 2020, 49(1): 58-70.
[14] 李艾,张添源,高建青. 间充质干细胞的肿瘤归巢特性及其肿瘤靶向治疗应用研究进展[J]. 浙江大学学报（医学版）, 2020, 49(1): 20-34.
[15] 黄耀凭,杨凤,周天华,谢珊珊. Hippo信号通路及其在消化系统肿瘤中的作用研究进展[J]. 浙江大学学报（医学版）, 2020, 49(1): 35-43.