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钙调蛋白及其突变体与电压门控钠离子通道1.2异亮氨酸-谷氨酰胺基序的结合作用 |
宛昱君1( ),刘君妍2,王妤婷2,成小雨1,沙莎1,贾婉莹2,胡德邻1,李昕宇1,郭凤2,*( ) |
1. 中国医科大学临床医学专业, 辽宁 沈阳 110122 2. 中国医科大学药学院药物毒理教研室, 辽宁 沈阳 110122 |
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Effect of calmodulin and its mutants on binding to NaV1.2 IQ |
WAN Yujun1( ),LIU Junyan2,WANG Yuting2,CHENG Xiaoyu1,SHA Sha1,JIA Wanying2,HU Delin1,LI Xinyu1,GUO Feng2,*( ) |
1. Department of Clinical Medicine, China Medical University, Shenyang 110122, China 2. Department of Pharmaceutical Toxicology, School of Pharmacy, China Medical University, Shenyang 110122, China |
引用本文:
宛昱君,刘君妍,王妤婷,成小雨,沙莎,贾婉莹,胡德邻,李昕宇,郭凤. 钙调蛋白及其突变体与电压门控钠离子通道1.2异亮氨酸-谷氨酰胺基序的结合作用[J]. 浙江大学学报(医学版), 2020, 49(1): 71-75.
WAN Yujun,LIU Junyan,WANG Yuting,CHENG Xiaoyu,SHA Sha,JIA Wanying,HU Delin,LI Xinyu,GUO Feng. Effect of calmodulin and its mutants on binding to NaV1.2 IQ. J Zhejiang Univ (Med Sci), 2020, 49(1): 71-75.
链接本文:
http://www.zjujournals.com/med/CN/10.3785/j.issn.1008-9292.2020.02.06
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http://www.zjujournals.com/med/CN/Y2020/V49/I1/71
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1 |
SHAO D , ZHAO M , XU J et al. The individual N- and C-lobes of calmodulin tether to the Cav1.2 channel and rescue the channel activity from run-down in ventricular myocytes of guinea-pig heart[J]. FEBS Lett, 2014, 588 (21): 3855- 3861
doi: 10.1016/j.febslet.2014.09.029
|
2 |
KWONG K , CARR M J . Voltage-gated sodium channels[J]. Curr Opin Pharmacol, 2015, 22:131- 139
doi: 10.1016/j.coph.2015.04.007
|
3 |
BEN-JOHNY M , DICK I E , SANG L et al. Towards a unified theory of calmodulin regulation (calmodulation) of voltage-gated calcium and sodium channels[J]. Curr Mol Pharmacol, 2015, 8 (2): 188- 205
doi: 10.2174/1874467208666150507110359
|
4 |
EDINGTON S C , HALLING D B , BENNETT S M et al. Non-additive effects of binding site mutations in calmodulin[J]. Biochemistry, 2019, 58 (24): 2730- 2739
doi: 10.1021/acs.biochem.9b00096
|
5 |
KAWASAKI H , KRETSINGER R H . Conformational landscape mapping the difference between N-lobes and C-lobes of calmodulin[J]. J Inorg Biochem, 2017, 177:55- 62
doi: 10.1016/j.jinorgbio.2017.08.025
|
6 |
HE G , GUO F , ZH UT et al. Lobe-related concentration- and Ca2+-dependent interactions of calmodulin with C- and N-terminal tails of the CaV1.2 channel[J]. J Physiol Sci, 2013, 63 (5): 345- 353
doi: 10.1007/s12576-013-0270-y
|
7 |
郑敏, 王千慧, 封瑞 et al. Nav1.2 IQ及其癫痫突变体的表达纯化和活性鉴定[J]. 解剖科学进展, 2016, 22 (2): 176- 178 ZHENG Min , WANG Qianhui , FENG Rui et al. Expression, purification and bioactivity identification of Nav1.2 IQ and its epileptic mutant[J]. Progress of Anatomical Sciences, 2016, 22 (2): 176- 178
doi: 10.16695/j.cnki.1006-2947.2016.02.017
|
8 |
年青洋, 李佳宁, 佟欣 et al. 钙调蛋白对电压门控性钠通道NaV 1.1的调节作用[J]. 解剖科学进展, 2019, 25 (2): 213- 215, 219 NIAN Qingyang , LI Jianing , TONG Xin et al. The modulating effect of CaM on voltage-gated sodium channel Nav1.1[J]. Progress of Anatomical Sciences, 2019, 25 (2): 213- 215, 219
doi: 10.16695/j.cnki.1006-2947.2019.02.028
|
9 |
MAKINSON C D , DUTT K , LIN F et al. An Scn1a epilepsy mutation in Scn8a alters seizure susceptibility and behavior[J]. Exp Neurol, 2015, 275P3 (1): 46- 58
doi: 10.1016/j.expneurol.2015.09.008
|
10 |
MANTEGAZZA M , BROCCOLI V . SCN1A/Nav1.1 channelopathies:Mechanisms in expression systems, animal models, and human IPSC models[J]. Epilepsia, 2019, 60 (Suppl 3): S25- S38
doi: 10.1111/epi.14700.Review
|
11 |
BERECKI G , HOWELL K B , DEERASOORIYA Y H et al. Dynamic action potential clamp predicts functional separation in mild familial and severe de novo forms of SCN2A epilepsy[J]. Proc Natl Acad Sci U S A, 2018, 115 (24): E5516- E5525
doi: 10.1073/pnas.1800077115
|
12 |
XIE A , GALLANT B , GUO H et al. Functional cardiac Na+ channels are expressed in human melanoma cells[J]. Oncol Lett, 2018, 16 (2): 1689- 1695
doi: 10.3892/ol.2018.8865
|
13 |
GUAN G , ZHAO M , XU X et al. Abnormal changes in voltage-gated sodium channels subtypes NaV1.1, NaV1.2, NaV1.3, NaV1.6 and CaM/CaMKII pathway in low-grade astrocytoma[J]. Neurosci Lett, 2018, 674:148- 155
doi: 10.1016/j.neulet.2018.03.047
|
14 |
LI J , YU ZH , XU J et al. The effect of Ca2+, lobe-specificity, and CaMKII on CaM binding to NaV1.1[J]. Int J Mol Sci, 2018, 286 (14): 12308- 12316
doi: 10.3390/ijms19092495
|
15 |
ISBELL H M , KILPATRICK AM , LIN Z et al. Backbone resonance assignments of complexes of apo human calmodulin bound to IQ motif peptides of voltage-dependent sodium channels NaV1.1, NaV1.4 and NaV1.7[J]. Biomol Nmr Assign, 2018, 12 (2): 1- 7
doi: 10.1007/s12104-018-9824-5
|
16 |
HOVEY L , FOWLER C A , MAHLING R et al. Calcium triggers reversal of calmodulin on nested anti-parallel sites in the IQ motif of the neuronal voltage-dependent sodium channel NaV 1.2[J]. Biophys Chem, 2017, 224:1- 19
doi: 10.1016/j.bpc.2017.02.006
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